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Öğe Antioxidant therapy impresses in oxidative stress-induced kidney cells(Comenius Univ, 2017) Alpay, Merve; Kısmalı, Görkem; Meral, Öğünç; Sel, Tevhide; Özmerdivenli, Recep; Pasin, ÖzgeINTRODUCTION: Renal cell cancer (RCC) is not a single entity, but consists of different types of tumors derived from various parts of the nephron (epithelium or renal tubules). It is known that cancer initiation and progression is related to the balance between oxidants and antioxidants directly. Interestingly, advanced stages of cancer such as metastasis, angiogenesis are associated with cell oxidative capacity. Familiar antioxidative substances such as carotenes and vitamin C inhibit oxidation of other molecules during carcinogenesis. They can define the distinction between cancer and normal cells, destroying cancer cells while stabilizing healthy cells. METHODS: apoptotic activities of kidney cells were measured with caspase Elisa kits. DNA laddering test was used to show DNA damage in H2O2 condition. RESULTS: For tumor mechanism, they act as pro-oxidants, producing hydrogen peroxide that attacks the cancer, whereas, in normal conditions they act as protective antioxidants. CONCLUSIONS: The unlike reaction of specific antioxidants should be known at different cell stages. The aim of this study was to assess the antioxidative roles of alpha lipoic acid on kidney cancers during oxidative stress induction (Tab. 1, Fig. 7, Ref 27). Text in PDF www.elis.sk.Öğe Comparing Performances of Multiple Comparison Methods in Commonly Used 2 x C Contingency Tables(Springer Heidelberg, 2016) Cangür, Şengül; Ankaralı, Handan; Pasin, ÖzgeThis study aims at mentioning briefly multiple comparison methods such as Bonferroni, Holm-Bonferroni, Hochberg, Hommel, Marascuilo, Tukey, Benjamini-Hochberg and Gavrilov-Benjamini-Sarkar for contingency tables, through the data obtained from a medical research and examining their performances by simulation study which was constructed as the total 36 scenarios to 2 x 4 contingency table. As results of simulation, it was observed that when the sample size is more than 100, the methods which can preserve the nominal alpha level are Gavrilov-Benjamini-Sarkar, Holm-Bonferroni and Bonferroni. Marascuilo method was found to be a more conservative than Bonferroni. It was found that Type I error rate for Hommel method is around 2 % in all scenarios. Moreover, when the proportions of the three populations are equal and the proportion value of the fourth population is far at a level of +/- 3 standard deviation from the other populations, the power value for Unadjusted All-Pairwise Comparison approach is at least a bit higher than the ones obtained by Gavrilov-Benjamini-Sarkar, Holm-Bonferroni and Bonferroni. Consequently, Gavrilov-Benjamini-Sarkar and Holm-Bonferroni methods have the best performance according to simulation. Hommel and Marascuilo methods are not recommended to be used because they have medium or lower performance. In addition, we have written a Minitab macro about multiple comparisons for use in scientific research.Öğe Comparison of sampling distributions and performances of Minitab and Freund & Perles quartiles(ISOSS PUBLICATIONS, 2015) Cangür, Şengül; Pasin, Özge; Ankaralı, HandanThis paper is aimed to compare sampling distributions and performances of Minitab and Freund & Perles quartile estimators using Monte Carlo-simulation. The study is constructed by two estimators, four different sample sizes with odd and even number of observations and three different distributions. As a result of simulation study, sampling distributions of the related statistics are analogous to population distributions in small samples when they are similar to normal distribution in large samples. Also, the statistics of two quartiles estimators (Q1 or Q3) are found to have similar performance in large samples. We suggest that Freund & Perles method is used for the asymmetrical distributions and small samples. © 2015 Pakistan Journal of Statistics.Öğe Comparison of the Effectiveness of Platelet-Rich Plasma, Corticosteroid, and Physical Therapy in Subacromial Impingement Syndrome(Turkish League Against Rheumatism, 2019) Pasin, Tuğçe; Ataoğlu, Safinaz; Pasin, Özge; Ankaralı, HandanObjectives: This study aims to investigate and compare the efficacy of platelet-rich plasma (PRP) injection, corticosteroid injection, and physical therapy in addition to exercise treatment on pain, shoulder functions, and quality of life in patients with subacromial impingement syndrome (SAIS). Patients and methods: Ninety patients (37 males, 53 females; mean age 48.99 years; range, 33 to 60 years) who were diagnosed as Stage 2 SAIS were included in the study. Patients were randomized into three groups. PRP injection was administered into the subacromial space of the affected shoulder in group 1, corticosteroid injection was administered in the subacromial joint space in group 2, and 10 sessions of physical therapy were given in group 3 five times weekly including transcutaneous electrical nerve stimulation, ultrasound, and hot packs. Moreover, an exercise program was administered in all groups. visual analog scale (VAS) was used to determine the resting and moving shoulder pain; while the Shoulder Disability Questionnaire, Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire, and the University of California, Los Angeles Shoulder Rating Scale (UCLA SRS) were used to evaluate the functionality of patients. Quality of life was analyzed using a generic Short Form 36 (SF-36). Results: All scores improved in all three groups compared with the period before treatment. Comparison of the groups showed higher scores in group 1 compared to groups 2 and 3 at week eight on QuickDASH, UCLA SRS, VAS at rest and during activity, and SF-36 pain subgroup scores. Conclusion: All three treatment modalities were effective in the treatment of SAIS. However, we suggest that the inexpensive and noninvasive methods of physical therapy and exercise should be the first preferred treatment in SAIS owing to causing no adverse events.Öğe Determination of the Appropriate Quality of Life Scale for Patients with Rheumatoid Arthritis and Osteoarthritis(2018) Ataoğlu, Safinaz; Ankaralı, Handan; Ankaralı, Seyit; Pasin, ÖzgeObjectives: A large number of quality?of?life scales are used to assess the effects of various diseases onthe quality of life. The most commonly used scale is the SF?36 quality of life scale. However, in recentyears various versions and shorter forms of this scale have been developed. Quality of life scales, whichcan be applied in a shorter period and which can be interpreted more easily and which producereliable and valid results, are preferred more. The purpose of this study is to determine the scales thatmeasure the quality of life better and practical would be appropriate in Osteoarthritis (OA) andRheumatoid Arthritis (RA).Materials and Methods: Cronbach's alpha coefficient was used for the internal consistency of thescales, the intra?class correlation coefficient was used for relations between item?total score, and theagreement between SF?36 scale and other short forms, and also the Spearman Rank correlation analysiswere used for evaluation of the relationships between the total scores of the scales. The criterion validityof the short forms (SF) of the quality of life scale were investigated by using WHOQOLBref andQuickDASH scales.Results: The internal consistency of the scales were found to be at a quite good level. In OA patients,the highest agreement in Physical Function, Bodily Pain and Vitality sub?dimensions of the SF?6D scalewere found. On the other hand, Physical Role, Emotional Role and General Health sub?dimensions inthe SF?12 scale have higher agreement. In RA, Bodily Pain and Vitality sub?dimensions of the SF?6D werefound to have higher agreement, and the SF?12 scale have higher agreement in the Physical Function,Physical Role, General Health and Emotional Role. Moreover, in both disease groups, the validity ofSF?12 and SF?6D scales was similar to each other in many conditions, and better than the SF?8 scale.Conclusion: According to the results, SF?12 or SF?6D scales could be used effectively to evaluate thequality of life in RA and OA patients.Öğe HCT116 İnsan Kolon Kanseri Hücrelerinde Endemik Phlomis Ekstraktlarının Antikanser Aktivitesi(2023) Kurman, Yener; Pasin, ÖzgeAmaç: Önceki çalışmalar, Phlomis russeliana'nın çeşitli kanser hücre hatlarına karşı sitotoksik etkiler gösterdiğini bildirmiştir; ancak, HCT-116 kanser hücreleri üzerindeki anti kanser aktivitesi henüz araştırılmamıştır. Bu nedenle, bu çalışma Phlomis russeliana'nın HCT-116 insan kolon kanseri hücre dizisi ve HUVEC normal hücre dizisine karşı anti-kanser özelliklerini araştırmak üzere tasarlanmıştır. Gereç ve Yöntemler: HCT-116 ve HUVEC hücreleri Phlomis russeliana’nın farklı konsantrasyonları (2, 4, 6, 8 ve 10 mg/ml) ile muamele edildi ve hücre canlılığı MTT yöntemi ile değerlendirildi. Phlomis russeliana'nın anti-migrasyon ve anti-kolonijenik etkileri, sırasıyla yara iyileşmesi ve koloni oluşumu analizleri ile değerlendirildi. Kolorimetrik Elisa kitleri ile toplam antioksidan durumunun (TAS), toplam oksidan durumunun (TOS) ve kaspaz-3 aktivasyonunun kantitatif tespiti yapıldı. Bulgular: Phlomis russeliana, konsantrasyona bağlı olarak HCT-116 hücrelerinin canlılığını önemli ölçüde azalttı ve normal HUVEC'lere karşı daha zayıf toksisite gösterdi. Phlomis russeliana, HCT-116 hücrelerinin göçünü ve koloni oluşturma potansiyelini önemli ölçüde engelledi. Phlomis russeliana ile tedaviden sonra kaspaz-3 aktivasyonunda önemli bir artış gözlendi. Phlomis russeliana, HCT-116 hücrelerinde TAS ve TOS seviyesini önemli ölçüde etkilemedi. Sonuç: Bu sonuçlar; Phlomis russeliana'nın koloni oluşumunun baskılanması, migrasyonun engellenmesi ve kaspaz-3 aktivasyonunun indüklenmesi yoluyla insan kolon kanseri hücrelerinde anti-kanser aktivitesi gösterdiğini ortaya koydu. Phlomis russeliana, kansere karşı yeni anti-kanser ajanlarının geliştirilmesi için umut verici bir kaynak olabilir.Öğe An investigation of childhood trauma in patients with panic disorder(Nobelmedicus, 2018) Ölmez, Safiye Bahar; Ataoğlu, Büşra Bahar; Kocagöz, Zehra Başar; Pasin, ÖzgeObjective: It is widely known that childhood traumatic experiences are mostly associated with psychiatric disorders. In this study, the relationship between childhood traumatic experiences and panic disorder (PD) development was examined with regards to all types of traumas including sexual abuse, physical abuse, emotional abuse, emotional neglect, and physical neglect. Material and Method: The sample for this study consisted of 59 outpatients and 61 healthy individuals serving as the control group. These individuals in the experimental group were selected from outpatients who had been diagnosed with PD based on American Psychatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria and who did not have any other psychiatric disorder. The Childhood Trauma Questionnaire (CTQ-28) was filled by the individuals themselves and the socio-demographic form by the researcher on behalf of them. Results: The main finding is that the individuals in the experimental group were found to have significantly high scores in comparison to those in the control group with respect to the total CTQ score (p=0.006) and specifically, the emotional neglect (p=0.004) and the emotional abuse sub-scores (p=0.009). Conclusion: The results revealed that the type and quality of trauma experienced during the childhood period can be a predictor for the psychiatric disorder subtype that can occur in the future years. © 2018, Nobelmedicus. All rights reserved.Öğe AN INVESTIGATION OF CHILDHOOD TRAUMA IN PATIENTS WITH PANIC DISORDER(Nobel Ilac, 2018) Ölmez, Safiye Bahar; Ataoğlu, Büşra Bahar; Kocagöz, Zehra Başar; Pasin, ÖzgeObjective: It is widely known that childhood traumatic experiences are mostly associated with psychiatric disorders. In this study, the relationship between childhood traumatic experiences and panic disorder (PD) development was examined with regards to all types of traumas including sexual abuse, physical abuse, emotional abuse, emotional neglect, and physical neglect. Material and Method: The sample for this study consisted of 59 outpatients and 61 healthy individuals serving as the control group. These individuals in the experimental group were selected from outpatients who had been diagnosed with PD based on American Psychatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria and who did not have any other psychiatric disorder. The Childhood Trauma Questionnaire (CTQ-28) was filled by the individuals themselves and the socio-demographic form by the researcher on behalf of them. Results: The main finding is that the individuals in the experimental group were found to have significantly high scores in comparison to those in the control group with respect to the total CTQ score (p=0.006) and specifically, the emotional neglect (p=0.004) and the emotional abuse sub-scores (p=0.009). Conclusion: The results revealed that the type and quality of trauma experienced during the childhood period can be a predictor for the psychiatric disorder subtype that can occur in the future years.Öğe Parametrik Olmayan Çok Değişkenli Varyans Analizi ve Sağlık Alanında Bir Uygulaması(2016) Pasin, Özge; Ankaralı, Handan; Cangür, Şengül; Sungur, Mehmet AliSağlık araştırmalarında, etkenlerin genellikle birbirleriyle ilişkili birden fazla sonucu olabilir. Bu ilişkili sonuçları ayrı analiz etmek 1.Tip hatanın artmasına neden olur. Ancak pratik uygulamalarda veri analizinde sıklıkla bu hata yapılmakta, daha basit, kolay yorumlanabilen tek değişkenli analiz yöntemlerinden yararlanılmaktadır. Ayrıca sağlık araştırmalarındaki özelliklerin önemli bir bölümü tek değişkenli parametrik modellerin varsayımlarından olan normal dağılım ve varyansların homojenlik ön şartlarını sağlamamaktadır. Dolayısıyla söz konusu araştırmaların daha doğru ve güvenilir sonuç üretmesi için yeni yaklaşım ve yöntemlerin tanıtılması ve uygulanması zorunlu hale gelmektedir. Bu amaçla, ölçülen özellikler arasındaki ilişkileri göz önüne alan ve varsayımları az olan parametrik olmayan MANOVA (PERMANOVA, Permutational Multivariate Analysis of Variance) modelinin teorik özellikleri tanıtılmış, klinik araştırmadan elde edilen bir veri setine uygulanarak sonuçlar tartışılmıştır. Çalışma sonucunda Hashimato hastalığı varlığı ve cinsiyet ile lipid profili değerleri arasındaki ilişkiler incelenmiş, Hashimato olanlarda lipid değerlerinin cinsiyete göre değişmemekle birlikte sağlıklı bireylerden anlamlı düzeyde yüksek olduğu bulunmuştur. Sonuç olarak,tabiatta veya insan vücudunda birçok özellik birbirini etkileyen ilişkileri birlikte dikkate alarak biyolojik yapıları gerçeğe daha yakın inceleyebilmek için ön koşulları fazla olmayan esnek istatistik modellere ihtiyaç duyulur. Bu sorunlara çözüm olarak günümüzde henüz uygulaması yaygınlaşmamış olan PERMANOVA modelinin kullanılmasını önerilmektedirÖğe Perspective of University Students towards Syrian Refugees in Turkey(Düzce Üniversitesi, 2017) Ankaralı, Handan; Pasin, Özge; Karacan, Büşra; Tokar, Mehdi; Künüroğlu, Merve; Çaça, Muhammed; Özislam, Muhammed EnesIn recent years, Syrians whose country have caos due to Syrian civil war that caused the biggest wave of immigration, have taken refuge in neighboring countries, especially to Turkey. As a result of the growth of the caos, there has been activity in the border regions of our country. Nearly 3.5 million immigrants live in our country. This number is very important in terms of Turkey population. This immigration brings some problems. Immigration problems are economic social, political implications. In the light of the problems, in this study we examined Syrian refugees which is today’s current issues. The differences of the language, culture and lifestyle make social adjustment difficult and distorted structures are increasing. Also in the economic sense, for example, there have been significant increases in health expenditures. There are also difficulties in terms of employment. Issue of Syrian refugees which are among the contemporary issues in the framework of the problems that arise is investigated in this study. The purpose of the study is to evaluate the perspective of young people to refugees. For this, data gathered by questionnaire with the help of stratified sampling from the students studying certain faculties at Duzce University and is examined their points of view on the related problems. The aim of the study is to reflect the perspectives of young people in our country to the Syrian refugees. As a result, it was seen that the attitudes of women towards refugees are more positive than men. Also it was seen that the opinions of family and relatives affected the attitudes of individuals. Our study shows that the students from Eastern Anatolia and Southeastern Anatolia regions, which are more closely related to immigrants due to their physical proximity, are in a more positive attitude towards refugees.Öğe Sağlık alanında yapılan araştırmalarda kümeleme algoritmalarının kullanımı: Bir uygulama(Düzce Üniversitesi, 2015) Pasin, Özge; Ankaralı, HandanKümeleme yöntemleri ile benzer özelliklere sahip değişken ve bireyler bir grupta toplanabilmektedir. Birçok uygulama alanına sahip olmasına rağmen kümeleme yöntemi ülkemizde sağlık araştırmalarında nadir olarak kullanılmaktadır. Bu tez çalışmasının amacı, farklı kümeleme algoritmalarını tanıtmak ve bu algoritmaların nasıl ve hangi durumlarda doğru bir şekilde kullanılabileceğini göstermektir. Aynı zamanda sağlık alanından elde edilmiş gerçek bir veri seti üzerinde uygulanabilir olan farklı kümeleme algoritmalarının sonuçlarını karşılaştırmaktır. Yapılan değerlendirmeler sonucunda kullanılan iki farklı veri seti için hesaplanan kappa katsayıları istatistiksel olarak orta düzeyde anlamlı bulundu. Gerçekleştirilen uygulama sonucunda her iki veri seti için de kappa katsayısı bakımından en uygun ve en hızlı sonuçlar üreten algoritmanın En Uzak İlk Kümeleme Yöntemi olduğu sonucuna varıldı. Framingham risk grupları ile oluşturulan kümeler arasında çapraz tablolar oluşturularak grupların dağılımı incelendiğinde ise, en isabetli kararların Make Density Based ve EM algoritmalarıyla elde edilen kümeleme sonuçları olduğu görüldü. Sonuç olarak kümeleme yöntemlerinin hastalıklara ait risk faktörlerinin incelenmesinde, klinik bilgileri de dikkate alarak hastalık gruplarının oluşturulmasında ve buna bağlı olarak da doğru hastalık teşhislerinin konulmasında önemli bir yol oynacağı düşünülmektedir. Ayrıca veri dağılımı ve özellikleri dikkate alınarak kullanıldığında kümeleme algoritmalarının, sağlık alanında her türlü planlama ve hastalık teşhisi için bir tanı aracı olarak kullanılabileceği kanısındayız.Öğe Sağlık Alanında Yapılan Araştırmalarda Kümeleme Algoritmalarının Kullanımı: Bir Uygulama(2016) Pasin, Özge; Ankaralı, HandanFarklı kümeleme algoritmalarını, algoritmaların nasıl ve hangi durumlarda doğru bir şekilde kullanılabileceğini tanıtmaktır. Aynı zamanda sağlık araştırmalarından elde edilmiş gerçek bir veri seti üzerinde uygulanabilir olan farklı kümeleme algoritmalarının sonuçlarını karşılaştır-- maktır. Gereç ve Yöntemler: Kardiyovasküler rahatsızlığına sebep olabilecek risk faktörleri ince-- lenerek bireyler düşük, orta ve yüksek riskli olarak gruplandırabilmek için farklı kümeleme algoritmaları kullanıldı. Kümeleme algoritması olarak EM (expectation maximization), En uzak ilk, Yoğunluk kümeleme, K--Medoid ve Cascade K--ortalama, K--ortalama yöntemleri kullanılmıştır. Bulgular: Yapılan değerlendirmeler sonucunda kullanılan iki farklı veri seti için hesaplanan uyum katsayıları istatistik olarak anlamlı bulundu ancak bu katsayılar orta derecede bir uyumu gösterdi. Gerçekleştirilen uygulama sonucunda her iki veri seti içinde kappa katsayısı bakımından en uygun ve en hızlı sonuçlar üreten algoritmanın en uzak ilk kümeleme yöntemi olduğu sonucuna varıldı. Framingham risk grupları oluşturulan kümeler arasında çapraz tablolar oluşturularak grupların da-- ğılımı incelendiğinde ise, en isabetli kararların Make Density Based ve EM algoritmalarına ait kü-- melerden elde edildiği görüldü. Sonuç: Sonuç olarak kümeleme yöntemlerinin hastalıklara ait risk faktörlerinin incelenmesi ve klinik bilgiler de dikkate alınarak hastalık gruplarının oluşturul-- masında, doğru hastalık teşhislerinin konulmasında önemli kullanım alanlarına sahip olacağı düşünülmektedir. Ayrıca kümeleme algoritmaları veri dağılımları ve özellikleri dikkate alınarak kullanıldığında sağlık alanında her türlü planlama ve teşhis için kullanılabilir, sonuçta iyi bir araç olacağı düşüncesindeyiz.Öğe The Investigation Effects of Pregabalin and Duloxetine Treatment According to Personality Characteristics Groupe with Fibromyalgia Patients(Düzce Üniversitesi, 2016) Çelebi, Esra; Ataoğlu, B Bahar; Ankaralı, Handan; Özşahin, Mustafa; Pasin, Özge; Ataoğlu, Saf NazThis study was to compare the effects of duloxetine and pregabalin on fibromyalgia(FMS)patients with different personalities. A total of 102 female with FMS who applied to outpatient clinics of the Department of PhysicalMedicine and Rehabilitation in Duzce University Medical School between October (2013)December (2014),were grouped according to their personality characteristics. Each personalitygroup was also randomly divided in two groups. One group received 60 mg/day duloxetine andthe other group received 300 mg/day pregabalin for 12 weeks.The pain intensity of the patientswas evaluated with VAS,their sleep quality was evaluated with VAS–sleep score,depression wasevaluated with Beck Depression Scale(BDS), quality of life was evaluated with SF-36, andfunctioning was evaluated with Fibromyalgia Impact Questionnaire(FIQ) before and aftertreatment. Thirty of the neurotic group received duloxetine, 31 received pregabalin while 20 of theextroverts received duloxetine and 21 received pregabalin.Significant improvements wereobtained in the neurotic-duloxetine and extroverted-pregabalin groups in terms of BDS andgeneral health perceptions dimension of SF-36. Significant improvements were observed in allgroups in terms of VAS,VAS-Sleep and sensitive points.The increase after treatment in physicalfunctioning,physical role functioning, vitality,mental health and bodily pain in SF-36 wassignificant in all groups.The increase in emotional role functioning was significantly higher inonly neurotic-duloxetine and neurotic–pregabalin groups.Whereas the effects of treatments werenot found statistically significant on vitality in all groups.The decrease in FIQ scores wassignificant in extroverted–duloxetine and extroverted–pregabalin groups. Treatment should be initiated with pregabalin in extroverts, and duloxetine in neuroticsÖğe Usage of heckman sample selection model in health studies: An application of prostate cancer patients(Turkiye Klinikleri, 2017) Pasin, Özge; Ankaralı, Handan; Yeşilyurt, LeventObjective: The objective of this study is to introduce theoretical characteristics of Heckman sample selection regression model,to clarify when it is required to be used and to show its usage in health area. Material and Methods: Heckman selection model, which is an appropriate tool for addressing the sample selection bias, was used for determining the risk factors of Gleason score for three datasets which have 2000 observations obtained from simulation study. The data was about the prostate cancer patients. In the data, there were benign tumor structures or stage 1 tumors in the study besides malign tumors but Gleason score was not calculated when tumor is benign. So sample selection bias is a matter for nonresponse Gleason score answers in our data. Also the model was performed for the datasets that have 0.30; 0.50 and 0.70 of censored proportion (nonresponse Gleason score) individual number by considering actual structures between variables with the help of simulation. Results: There was no significant relationship between Gleason score and smoking, family history. But we found that age, PSA(prostate specific antigen) and weight variables have significant relationship with Gleason score (p<0.001). Adjusted standard error value was the highest in dataset with 0.50 censored proportion, and the lowest in data set with highest censor proportion (0.70). Among models the lowest log likelihood value has been determined in model with 0.50 censor proportion. Conclusion: When there is sample selection bias on dependent variable, Heckman sample selection regression model can be suggested. In addition, researchers can have more accurate results by increasing the use of these models in health sciences. © 2017 by Türkiye Klinikleri.
