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    The Relation Between Serum Alpha Defensin-1 Levels with Clinical Course and Prognosis in Crimean-Congo Hemorrhagic Fever
    (2022) Parlak, Mehmet; Laloğlu, Esra; Bayar, Meral; Yılmaz, Sinan; Parlak, Emine
    Aim: Crimean-Congo Hemorrhagic Fever (CCHF) is a viral zoonotic infection characterized by fever and bleeding. Alpha-defensin-1 (AD-1) is an antimicrobial peptide. The aim of this study was to investigate the relationship between the clinical course and prognosis of CCHF and AD-1 serum levels, and also to examine the role of AD-1 in the pathogenesis of the disease.Material and Methods: Fifty patients diagnosed with CCHF and hospitalized at the Atatürk University Faculty of Medicine Department of Infectious Diseases and Clinical Microbiology, and 38 healthy control were included in this study. Serum AD-1 levels were measured using ELISA methods and compared between the groups.Results: Serum AD-1 levels in the patients were significantly higher than those in the control group (p=0.017). Of the patients, 18 (36%) were classified as severe clinical course, 16 (32%) as moderate clinical course, and 16 (32%) as mild clinical course. There was no statistically significant difference among the three groups in terms of serum AD-1 levels (p=0.729). Median serum AD-1 levels were 171.0 (range, 126.8-221.2) ng/ml in the fatal cases, and 118.7 (range, 91.9-183.3) ng/ml in the surviving patients, and the difference between these two groups was statistically significant (p=0.014).Conclusion: As a result, the increased serum AD-1 levels in CCHF patients, remained higher in severe course patients and in the fatal cases. On the basis of these results, AD-1 appears to indicate the clinical course and provide useful information about mortality. More extensive research should be performed to make generalizations on this subject.
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    Use of complementary and alternative medicine in patients with chronic viral hepatitis in Turkey
    (Churchill Livingstone, 2020) Ince, Nevin; Kaya, Safak; Yildiz, Ilknur Esen; Parlak, Emine; Bayar, Belkis
    Introduction: The global use of complementary and alternative medicine (CAM) is growing. The purpose of this study was to determine the prevalence of CAM use in patients in Turkey with CVH, the types of therapy, and patients' sociodemographic characteristics. Methods: The study was designed as a questionnaire-based, cross-sectional analysis. An infectious diseases outpatient follow-up questionnaire was administered to patients at face-to-face interviews. The data obtained were analyzed using SPSS 17 software. Results: This study included 588 patients, of whom 27% used CAM. No differences in sociodemographic characteristics were determined between patients using CAM and those not using it. Herbal methods were used by 63.6% of patients and cupping techniques by 25.4%. Education level was significantly correlated with herbal methods (p = 0.043). CAM use also increased in line with disease duration (p < 0.05). No difference in CAM use was determined between CHB patients using oral antiviral therapy and those not using it (p = 0.162). Conclusion: CAM use, particularly herbal products, is prevalent among Turkish adults with CVH. In case of use of herbal products in chronic viral hepatitis patients, toxicity and liver failure may develop as a result of herbal product-drug interactions. Physicians in the field of hepatology should, therefore, be aware of potential toxicity of CAM, especially in patients with chronic hepatitis liver diseases.