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    The Effect of BRAF T1799A Mutation on Tumor Size of Papillary Thyroid Cancer
    (Düzce Üniversitesi, 2013) Yamak, Nesibe; Oktay, Murat; Yaykaşlı, Emine; Önder, Elif; Oktay, Nilay Aydin; Aydın, Yusuf; Devlet, Düzce Atatürk
    Objective: The incidence of thyroid cancer, the most common endocrine malignancy isincreasing in all populations. Papillary thyroid cancer constitutes approximatelly 80 % of thethyroid cancers and several BRAF gene mutations escpecially T1799A are involved in theetiology of papillary thyroid cancer. The aim of this study was to investigate the frequency ofBRAF T1799A mutation in thyroid cancer and the possible association between BRAFT1799A mutation and tumor size.Methods: The study was conducted with 58 cases with thyroid cancer and 52 cases with nocancer in totally 108 cases. DNA isolated from paraffin-embedded tissues of cases, and thegenotypes were analyzed by PCR-RFLP method. Statistical analyses were performed usingSPSS 17.0 software. P values less than 0.05 were accepted as statistically significant.Results: There was no statistically significant association between patient and control groupsin term of the AA genotype. However TA genotype was significantly higher in patient groupthan control group (p=0.0001, OR=7.089 (2.7-18.6)). When comparing less and more than 1cm tumor size groups in papillary thyroid cancer cases, there was no statistically significantassociation for TA genotype (p=0,51, OR=0,641 (0,1-2,4)) and AA genotype (p=0,67,OR=0,694 (0,1-3,8)).Conclusion: Thyroid cancer has the most increasing rate among all cancers types in the world.So, the elucidation of the molecular basis in detail has gained the great importance. In thisstudy, it was concluded that BRAF T1799A mutation has no effect on tumor size. However,this study should be repeated with larger population to get more confident results