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  • Küçük Resim
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    Assessment of the Effect of Psoriasis and Methotrexate Treatment on Liver Stiffness by ARFI Imaging
    (Duzce Univ, Fac Medicine, 2023) Guclu, Derya; Karagun, Ebru; Unlu, Elif Nisa; Oktay, Mehtap; Pasin, Ozge
    Objective: To investigate whether psoriasis and methotrexate used in its treatment cause liver fibrosis and eventually to evaluate the safety of methotrexate in treatment.Methods: 44 cases were included in the study. Methotrexate-using (group 1, n=14) and methotrexate-not-using (group 2, n=13) psoriasis patients were compared retrospectively with a healthy control group (group 3, n=17) according to mean shear wave rates obtainedResults: Mean shear wave velocities were calculated as 2.57 & PLUSMN; 1.13 m/sec in the patients using methotrexate, 2.31 & PLUSMN; 1.16 m/sec in the patients who did not use methotrexate, and 1.56 & PLUSMN; 0.62 m/sec in the healthy control group. While the average shear wave velocity of the 3rd group was found to be significantly lower than that of the 1st and 2nd groups (p=0.032; p=0.012), no significant difference was observed between the 1st and 2nd groups (p=0.755).Conclusions: Shear wave imaging with ARFI quantification findings revealed no evidence that methotrexate therapy is associated with liver fibrosis in psoriasis patients and we think that the increase in liver tissue stiffness in patients using methotrexate for psoriasis is secondary to the inflammatory process caused by psoriasis itself rather than methotrexate.
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    Assessment of the frequency of deep venous thromboembolism in obstructive sleep apnea syndrome
    (Taylor & Francis Ltd, 2019) Bahar, Yağmur; Annakkaya, Ali Nihat; Şen, Çiğdem; Oktay, Mehtap; Aytekin, Fuat; Balbay, Öner Abidin
    The present study aimed to investigate the frequency of deep venous thrombosis (DVT) among patients with obstructive sleep apnea syndrome (OSAS). Patients who referred the preliminary diagnosis of OSAS were included in this study. D-dimer levels of all patients were measured, and D-dimer (+) patients were evaluated by Doppler USG of the lower-extremity. Mean age of the patient group was 52 +/- 12 years and 31.8% (76/239) were women. The rate of D-dimer positivity among severe-OSAS cases (15/85) was significantly higher compared to the rest (13/154) (17.6% and 8.4%, respectively; p = 0.034). The risk of D-dimer positivity was elevated by 2.3 folds in severe-OSAS cases (OR: 2,324, 95% confidence interval: 1.048-5.152). Among 28 D-dimer (+) cases, 4 (14.2%) had DVT as demonstrated by USI of the lower-extremity. All four cases with DVT had severe OSAS. D-dimer was positive in 17.6% (15/85) of all severe OSAS cases. DVT was diagnosed in 4.7% (4/85) of severe-OSAS cases. DVT frequency was 26.6% (4/15) in D-dimer (+) severe-OSAS. Findings of this study indicate that severe-OSAS can be a significant risk factor for DVT. Additionally, data obtained in this study underline the benefits of questioning severe-OSAS patients with respect to DVT symptoms, investigating D-dimer levels and evaluating D-dimer (+) severe-OSAS cases for DVT prophylaxis.
  • Küçük Resim Yok
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    Erişkinlerde patellar tendon elastikiyetinin dekatlara göre shear wave elastografi ile değerlendirilmesi
    (Düzce Üniversitesi, 2018) Oktay, Mehtap; Ünlü, Elif Nisa
    Çalışmamızın amacı, normal patellar tendonu shear wave elastografi ile değerlendirmek ve tendon elastikiyetinin yaş ile birlikte değişip değişmediğini saptamaktır. Çalışmaya 74'ü kadın ve 61'i erkek olmak üzere toplam 135 sağlıklı gönüllü birey dahil edilmiştir. Olgular dekatlara göre 20-29 yaş (1.Grup), 30-39 yaş (2.Grup), 40-49 yaş (3.Grup), 50-59 yaş (4.Grup) ve 60-69 yaş (5.Grup) olarak gruplandırılmıştır. Siemens Acuson-S2000 US cihazı ile 9L4 (4-9 MHz) lineer prob kullanılarak patellar tendonun uzunluğu ve üst, orta ve alt kısımlarda kalınlıkları ölçülmüştür. Virtual Touch Quantification (VTQ/ARFI) yöntemiyle üst, orta ve alt bölgenin elastografisi yapıldı ve sonuçlar birbirleriyle karşılaştırılmıştır. Olguların radyolojik parametreleri, BMI değerleri ile de karşılaştırılmıştır. Erkeklerde kadınlara göre tüm yaş gruplarında patellar tendon uzunluğu, kalınlığı ve SWV değerleri yüksek bulundu (p = 0,001). Yaş grubu arttıkça shear wave hızında istatistiksel olarak anlamlı azalma bulundu (p = 0,001). BMI ile SWV arasında zayıf negatif korelasyon bulundu. Çalışmamızın sonucunda, patellar tendon sertliğinde yaş ile birlikte istatistiksel olarak anlamlı azalma bulunmuştur. Bu konuda daha ileri çalışmalar yapılması daha net bilgilere ulaşılmasını sağlayacaktır. Sonuç olarak ultrason elastografi, patellar tendon değerlendirilmesinde US'ye yardımcı ve güvenilir bir yöntemdir.