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    New Antimicrobial Polymeric Microspheres Containing Azomethine
    (Springer, 2022) Ülke, Eyüp; Özkan, Elvan Hasanoğlu; Nartop, Dilek; Ogutcu, Hatice
    Herein, new polymeric microspheres containing azomethine (PS-OPA, PS-OPA-Pt, PS-OPA-Ni, PS-OPA-Mn and PS- OPA-Cu) were synthesized and investigated by elemental analysis, FT-IR, SEM-EDX, TGA-DTA, UV-Vis, GPC and magnetic susceptibility. Antibacterial and antifungal activities of the synthesized polymeric microspheres were evaluated against pathogenic bacteria (Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Staphylococcus aureus ATCC25923, Enterobacter aerogenes, Pseudomonas aeroginosa sp., Klebsiella pneumonia ATCC27853, Salmonella type H NCTC9018394, Proteus vulgaris RSKK96026, Escherichia coli ATCC1280) and yeast (Candida albicans Y-1200-NIH) by the well-diffusion method for potential biomedical applications. It was determined that polymeric microspheres exhibited higher inhibition effect against B. cereus, E. aerogenes, P. aeruginosa, P. vulgaris and showed higher antifungal activity than standard nystatin. [GRAPHICS] .
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    Synthesis and in Vitro Antimicrobial Evaluation of Novel Potent Bioactive Heterocyclic Compounds
    (Taylor & Francis Ltd, 2023) Macit, Ahsen Zeynep; Hasanoglu Ozkan, Elvan; Ogutcu, Hatice; Nartop, Dilek
    In the present work, the antibacterial and antifungal properties of six new heterocyclic Schiff bases (HSb1, HSb2, HSb3, HSb4, HSb5, HSb6) were evaluated as potential bioactive compounds against the disease-causing pathogenic microorganisms (S.epidermidis, S.aureus, B.cereus RSKK863, E.aerogenes, P.aeroginosa sp., K. pneumonia, S. type H, P.vulgaris, E. coli and (C.albicans Y-1200-NIH). The well-diffusion-method was used to determine the antimicrobial activity. For this purpose, heterocyclic Schiff bases were synthesized by condensation reaction of aldehyde derivatives and thiosemicarbazide derivatives. Spectral analysis techniques (organic elemental analysis, FT-IR,H-1-NMR, HRMS, SEM-EDX) were used to characterize the synthesized compounds. It was determined that all the newly synthesized heterocyclic Schiff bases exhibited sound, high or moderate inhibitory effects on the growth of selected different standard antibiotics. [Graphical Abstract]