Yazar "Meydan, Bayram" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Beyond pelvic pathology: retinal microvascular rarefaction as a systemic marker in endometriosis
    (Bmc, 2025) Keyif, Betul; Sezer, Taha; Colak, Kubra; Gundogdu, Zulfiye Balkan; Meydan, Bayram
    Objective This study aimed to quantitatively assess retinal microvascular alterations in women with pelvic endometriosis using optical coherence tomography angiography (OCTA), and to explore whether these subclinical findings may reflect early signs of systemic microvascular alterations in this population. Methods In this retrospective cross-sectional study, 100 eyes were analyzed-50 from women with laparoscopically or ultrasonographically confirmed pelvic endometriosis and 50 from age-matched healthy female controls. All participants underwent comprehensive ophthalmic examinations and macular OCTA imaging using the Heidelberg Spectralis system. Quantitative parameters, including vessel area density (VAD), foveal avascular zone (FAZ) metrics (area, perimeter, circularity), and FD-300 values, were extracted from the superficial and deep capillary plexuses using the OCTAVA software. Segmental parafoveal VAD values (nasal, temporal, superior, and inferior) were also assessed. Axial length measurements and endometriosis staging were not available in this retrospective dataset. Hormonal therapy use was not systematically documented. Results Compared to healthy controls, women with endometriosis demonstrated significantly lower total and parafoveal VAD and FD-300 values in both retinal plexuses (p < 0.05 for all). FAZ perimeter showed a modest but statistically significant difference, whereas FAZ area and circularity index remained comparable between groups. No participant in either group exhibited clinically visible retinal pathology. These alterations occurred despite preserved visual acuity and in the absence of systemic comorbidities known to affect microcirculation. Conclusion Although causality cannot be inferred from this cross-sectional design, our findings indicate that pelvic endometriosis is associated with region-specific subclinical reductions in retinal capillary perfusion, particularly within the foveal and parafoveal regions. OCTA-derived metrics, especially FD-300 and parafoveal VAD, may offer insight into microvascular integrity in this patient group. These results support further investigation into the systemic vascular aspects of endometriosis and highlight the potential utility of retinal imaging in exploring such associations.
  • Küçük Resim Yok
    Öğe
    Pupillographic evaluation accompanying structural and functional assessment of the optic nerve in patients with Parkinson's disease
    (Bmc, 2025) Bozkurt, Erdinc; Muhafiz, Ersin; Erdogan, Can Emre; Nizamogullari, Serif; Toprak, Guevenc; Meydan, Bayram
    Background To evaluate static and dynamic pupillary functions, contrast sensitivity, and retinal nerve fiber layer (RNFL) thickness in patients with Parkinson's disease. Methods The study included 25 right eyes of patients with Parkinson's disease (mean age: 67.88 +/- 9.40 years) and 26 right eyes of age- and sex-matched healthy controls (mean age: 64.15 +/- 7.60 years). Following the measurement of visual acuity and intraocular pressure, the RNFL thickness of the right eye was assessed using optical coherence tomography (Optovue, Inc., Fremont, CA, USA), and contrast sensitivity was measured with the CSV-1000E (Vector Vision, Dayton, OH, USA). Following a 5-minute period of dark adaptation, both static and dynamic pupillographic parameters were assessed using the Sirius corneal topography device (Sirius, CSO, Florence, Italy). Results There was no statistically significant difference between the groups in terms of age and sex (p = 0.126 and p = 0.579, respectively). RNFL thickness in the superior, inferior, nasal, and temporal quadrants of the right eye were as follows for Parkinson's and control groups, respectively: 133.6 +/- 18.03 vs. 144.73 +/- 17.44 mu m (p = 0.03), 122.0 +/- 14.47 vs. 134.96 +/- 25.28 mu m (p = 0.031), 67.76 +/- 12.05 vs. 74.65 +/- 12.05 mu m (p = 0.047), and 66.36 +/- 8.72 vs. 72.77 +/- 14.0 mu m (p = 0.057). A statistically significant thinning was observed in all quadrants except the temporal quadrant in Parkinson's patients (Fig. 1). Contrast sensitivity was significantly lower in the Parkinson's group across all spatial frequencies compared to controls (p = 0.03, 0.01, < 0.01, and 0.02, respectively) (Fig. 2). Although pupil sizes were smaller in the Parkinson's group under scotopic, mesopic, and photopic conditions in static pupillography, the differences were not statistically significant (p > 0.05). Similarly, in dynamic pupillography, the pupil diameters at 0, 2, 4, 8, 12, and 16 s were smaller in the Parkinson's group, but no statistically significant differences were found between the groups (p > 0.05) (Fig. 3). Conclusions While a significant reduction in RNFL thickness and contrast sensitivity was observed in patients with Parkinson's disease, static and dynamic pupillographic parameters did not differ significantly between the groups. Therefore, the prognostic utility of pupillography in Parkinson's disease remains inconclusive and should be further investigated in larger and longitudinal studies.