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    The Adriamycin Rat/Mouse Model And Its Importance To The Embryology
    (Düzce Üniversitesi, 2012) Kızılay, Gülnur; Akpolat, Meryem; Tarladaçalışır, Yeter Topçu; Metin, Melike Sapmaz; Uz, Yeşim Hülya
    Rat and mouse models induced by the teratogenic effect of adriamycin are reliable and easlyreproducible methods of studying the embryology and molecular biology of a range of complexcongenital anomalies similar to those seen in humans with VACTERL association. Themechanism by which adriamycin produces the congenital anomalies found in the VACTERLassociation is not yet clear. Studies with these models have focused on mainly abnormalnotochord morphology, shedding more light on the important role of this structure in thedeveloping embryo. Morover, defective Shh signaling pathway is another emphasizedmechanism. This review aims to discuss adriamycin rat and mouse models and their impact oncongenital anomalies similar to those seen in humans with VACTERL association, in the lightof current literature data