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    Applications of Dietary Supplements and Aromatherapy for Prophylactic and Treatment Purposes During COVID-19 Pandemic
    (Galenos Publ House, 2023) Mancak, Methiye; Caliskan, Ufuk Koca
    Objectives: The lack of a specific proven treatment for coronavirus disease-2019 (COVID-19) has led individuals to use different treatment options. Although their effects on COVID-19 have not been proven, interest in dietary supplements and aromatherapy has increased during the pandemic period. In this study, use of dietary supplements and aromatherapy was investigated for COVID-19 among individuals living within the borders of Turkiye.Materials and Methods: This cross-sectional survey study was conducted among 310 individuals. The questionnaire was prepared using online Google Forms and communicated to the participants via social media platforms. The data obtained from the study were analyzed with the statistical program.Results: The analyzes of the survey revealed that participants increased the usage of supplements mostly prophylactic and for treatment purposes during COVID-19 pandemic, 31.9% individuals declared that they consumed herbal tea/products, 38.1% of them used vitamin/mineral supplements (multivitamin-mineral, vitamins B1, B6, B12, C, D, calcium, coenzyme Q10, iron, magnesium, selenium, and zinc), and 18.4% of the individuals applied aromatherapy (meaning treatment with essential oils). As a result of the study, the most commonly used supplement was vitamin D, the most commonly consumed tea was green tea, the essential oil was thyme oil, and the most eaten vegetable was garlic. Moreover, other frequently used herbal products were found to contain ginger and onion as food and peppermint and eucalyptus oils as aromatherapeutics. Participants often reported that they found it safe to use elevated levels of herbs or herbal products against COVID-19.Conclusion: Among the individuals participating in this study, it has been observed that the use of dietary supplements has increased during the COVID-19 pandemic period. The study revealed that vitamin D is prominent in self-medication use. Moreover, interest in aromatherapy and dietary supplements has increased. Among aromatherapeutics, thyme stood out over the applied essential oils.
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    Are cinnamon derivatives effective and safe for diabetes?
    (Tubitak Scientific & Technological Research Council Turkey, 2025) Mancak, Methiye; Caliskan, Ufuk Koca
    Background/aim: Cinnamon spice is obtained by drying the tree bark of Cinnamomum Schaeff. species. The genus Cinnamomum belongs to the family Lauraceae, which comprises approximately 250 different species worldwide. The most common species on the Cinnamon and its byproducts have been used for many years due to their antidiabetic effect. In the current study, the major chemical content and in vitro antidiabetic activities of different commercially available cinnamon samples were evaluated to determine whether Materials and methods: Macroscopic analyses, chromatographic analyses, and enzyme inhibition assays on diabetes-related enzymes (alpha-amylase, alpha-glucosidase, and aldose reductase) were performed on seven different samples (cinnamon sticks, tea bags, and capsules). Results: The cinnamon samples inhibited diabetes-related enzymes. The aqueous and ethanolic extracts of different cinnamon species demonstrated 7.73-333.69 mg/g of trans-cinnamaldehyde, and up to 43.73 mg/g of coumarin. Decoction and ethanolic extracts of C. cassia, C. burmannii, and C. loureiroi cinnamon sticks were detected to contain high levels of coumarin, which could pose a health risk, according to European Food Safety Authority data. Although antidiabetic activity was observed in the ready-made samples purchased from a herbalist, trans-cinnamaldehyde or coumarin compounds were not detected in the high-performance liquid chromatography Conclusion: The source of the cinnamon spice is crucial for the utilization of cinnamon both in food and therapeutic purposes. This research once again showed the importance of meticulous inspection of the products sold by herbalists.
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    Evidence-based herbal treatments in liver diseases
    (Kare Publ, 2024) Mancak, Methiye; Altintas, Dudu; Balaban, Yasemin; Caliskan, Ufuk Koca
    The liver is the main organ for metabolic and detoxification reactions in the body. Therefore, its diseases can be associated with both metabolic disorders, such as insulin resistance, obesity, diabetes, or dyslipidemia, and exogenous insults such as drugs, xenobiotics, or alcohol. Indeed, lifestyle changes are the primary approaches for the prevention and treatment of liver diseases. Since ancient times, herbals have also been used for preventive and therapeu-tic purposes, because of their anti-apoptotic, anti-inflammatory, and antioxi-dant effects. Here, the literature was reviewed for potential therapeutic effects of plants and their compounds by including in vitro and in vivo studies, as well as clinical trials. Although the available data imply some beneficial roles of herbals on the liver, the indications and posology of specific plants need to be clarified through multicenter, randomized clinical trials.