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    Do Pediatric Patients with Familial Mediterranean Fever who have Phenotypically Predominant Arthritis, Arthralgia, and Myalgia Reflect a More Serious Underlying Disease than Those with Phenotypically Predominant Abdominal Pain?
    (2024) Kutlu Beseren, Tugba Nur; Ergüven, Müferet; Üstebay, Sefer
    Aim: The study aimed to determine the presence of different de - mographic, familial, clinical, laboratory, and genotypic characteris- tics between children with Familial Mediterranean Fever (FMF) with recurrent arthritis, arthralgia, and myalgia phenotype and children with FMF with recurrent abdominal attacks phenotype. Material and Method: The study included patients who were ad - mitted to the Pediatric Rheumatology Outpatient Clinic of the Kafkas University Research Hospital before 2020, who were diagnosed with FMF and followed up for at least 1 year, and who were diagnosed with clinically recurrent arthritis, arthralgia, myalgia, and recurrent abdomi- nal pain. Patients were divided into two groups: 151 patients with re- current arthritis, arthralgia, and myalgia with FMF phenotypic features (Group 1) and 102 patients with recurrent diffuse, incomplete perito- neal involvement with predominant FMF phenotypic features (Group 2). The demographic and familial characteristics, age at diagnosis, and other clinical, laboratory, and genetic features of these 2 groups were compared, and the differences were statistically evaluated. Results: While 60.6% of the patients in Group 1 and 39.4% in Group 2 were female, 58.7% of the patients in Group 1 and 41.3% in Group 2 were male. No significant statistical difference was found between the two groups. When the groups were compared regarding genetic mutations, M694V homozygotes were observed in 17.2% of Group 1 and 8.8% of Group 2. There was a statistically significant difference between Group 1 and Group 2 in M694V homozygotes (p<0.05) Conclusion: Patients with FMF with predominant recurrent arthri- tis, arthralgia, and myalgia tended to be diagnosed at an older age and exhibited more frequent symptoms such as pallor and nausea compared to patients with FMF who predominantly had peritoneal involvement. Furthermore, pleural involvement was frequently ob- served, and the co-occurrence with the homozygous M694V mu- tation was genotypically high.
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    Evaluation of Osteoarticular Involvement Associated with Brucellosis in Children
    (Duzce Univ, Fac Medicine, 2025) Kutlu Beseren, Tugba Nur; Bekis Bozkurt, Hayrunnisa; Erguven, Mueferet; Bicakci, Zafer
    Aim: Brucellosis is a significant public health problem with high morbidity. Its most frequent complication is osteoarticular involvement. The study aimed to evaluate the relationship of osteoarticular involvement with clinical features and prognosis in children with brucellosis. Material and Methods: This retrospective study included pediatric patients between the ages of 1 and 18 years who were hospitalized and diagnosed with brucellosis between 2015 and 2020, and were regularly followed up. Aand all their findings and osteoarticular involvement data within the last two years were recorded. Clinical features, laboratory findings, osteoarticular involvement, and relapse rates of the patients were evaluated. Results: A total of 80 patients were included study. During the follow-up period, relapse developed in 14 (17.5%) patients. The most commonly affected joints were right (40%, n=32) and left (26.3%, n=21) hips, then right (27.5%, n=22) and left (23.8%, n=19) knees. Shoulder joint involvement rates and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), alanine transaminase (ALT), and aspartate aminotransferase (AST) levels were statistically significantly higher in the relapse group (p=0.016, p=0.003, p=0.001, p<0.001, p<0.001, respectively). There was no significant difference in demographic characteristics, clinical features, and treatment responses of the patients between age groups, except weakness and sweating complaints that were high among older children (p=0.036). Conclusion: High admission ALT, AST, CRP, and ESR levels in brucellosis cases with osteoarticular involvement and the presence of shoulder joint involvement, albeit rarely, can be a warning sign in terms of relapse. Patients should be closely followed up in terms of brucellosis complications.