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    ALANINE AMINOTRANSFERASE LEVELS AND MONOCYTE COUNT INDEPENDENTLY PREDICT 30-DAY OUTCOMES IN ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS WITH SUCCESSFULLY RESTORED CORONARY TIMI-3 FLOW BY PRIMARY PERCUTANEOUS CORONARY INTERVENTION
    (Düzce Üniversitesi, 2014) Çetin, Mustafa; Kocaman, Sinan Altan; Durakoğlugil, Murtaza Emre; Çanga, Aytun; Çiçek, Yüksel; Akgül, Özgür; Gül, Mehmet
    Aim: To investigate the relationship of various hematological and biochemical parametersbesides the cardiac enzymes with 30-day outcomes in patients with successfully restoredcoronary TIMI-3 flow by primary percutaneous coronary intervention (p-PCI).Materials and methods: Two hundred patients with ST elevation myocardial infarction(STEMI), with no history of prior myocardial infarction (MI), who underwent p-PCI and hadTIMI-3 flow, were enrolled, consecutively. The primary endpoint of the study was defined asthe composite of death, fatal and non-fatal MI, target vessel revascularization andcerebrovascular event.Results: Only ALT concentration (OR: 1.010, 95% CI: 1.003-1.018, P = 0.008), monocytecount (OR: 1.002, 95% CI: 1.001 - 1.004, P = 0.005), hypertension (OR: 3.010, 95% CI: 1.081- 8.384, p = 0.035) and lower LVEF (OR: 0.926, 95% CI: 0.875 - 0.981, P = 0.008) wereindependent predictors of primary endpoint in multivariate logistic regression analysis.Conclusion: We found that elevated liver enzymes as determined by serum Alanineaminotransferase levels and monocyte count as well as hypertension and lower LVEFindependently predicted 30-day outcomes in patients with successfully restored coronary flowby p-PCI. These parameters may provide new aspects, to identify the pathophysiology andprognosis of acute vascular events, which in turn may facilitate discovery of new treatmentmodalities