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    Identification of Sars-Cov-2 related volatile organic compounds from face masks
    (Elsevier, 2024) Canbay, Hale Secilmis; Kismali, Gorkem; Emen, Fatih Mehmet; Habiloglu, Arif Dogan; Sareyyupoglu, Baris; Akcay, Aytac; Ozturk, Hakan
    This study aims to identify SARS-CoV-2-related volatile organic compounds (VOCs) of the exhaled breath from face masks. Face masks collected from SARS-CoV-2 patients (n = 30) and the control group (n = 11) were analyzed to detect VOCs in the exhaled breath using the Headspace-Gas Chromatography Mass Spectrometry. Significant increases in concentrations of toluene, hexadecane, and phenol were detected in the face masks belonging to patient groups (p < 0.001). Clinical sig-nificance was further found in isobutyric acid levels considering Cohen's d value (p = 0.070). The findings of this study suggest that monitoring toluene, hexadecane, phenol, and isobutyric acid could provide considerable support in rapid screening of SARS-CoV-2.
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    Piperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cells
    (Wolters Kluwer Medknow Publications, 2020) Kismali, Gorkem; Ceylan, Ahmet; Meral, Ogunc; Alpay, Merve; Kosova, Funda; Cakir, Dilek Ulker; Sel, Tevhide
    Objective: To investigate whether piperlongumine can sensitize prostate cancer cells to tumor necrosis factor-related apoptosis- inducing ligand (TRAIL) and trigger apoptosis in prostate cells. Methods: Human prostate cancer cell lines PC3, LNCaP, and VCaP were cultured with piperlongumine and TRAIL. Then, cell proliferation, migration, caspase activation, apoptotic protein expressions, and death receptor expressions were measured. Results: Piperlongumine inhibited cell proliferation at low doses (<10 mu M) alone and in combination with TRAIL (25 ng/mL), induced apoptosis, and suppressed cyclooxygenase activation. Additionally, piperlongumine induced expression of death receptors which potentiated TRAIL-induced apoptosis in cancer cells but did not affect decoy receptors. Piperlongumine also downregulated tumor cell-survival pathways, inhibited colony formation and migration of cancer cells alone or in combination with TRAIL. The combination of piperlongumine with TRAIL was found to be synergistic. Conclusions: Our findings indicate that piperlongumine can sensitize cancer cells to TRAIL through the upregulation of death receptors and can trigger apoptosis with the downregulation of anti- apoptotic proteins.