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Öğe Attitude and behaviors of mothers regarding fever in children; a Duzce University Faculty of Medicine study(Yusuf Haydar ERTEKİN, 2018) Kilicaslan, Onder; Sonmez, Cemil İsik; Dincer, Damla; Sengun, Yunus; Temizkan, Ramazan Cahit; Eroz, Recep; Kocabay, KenanIntroduction: In mothers with fever complaint who applied to Duzce University Faculty of Medicine Research and Practice Hostipal, defining attitude and behaviours and general knowledge levels about fever are aimed in this study.Methods: 230 patients who were admitted to pediatric emergency service and general pediatric outpatient clinics from February to June 2017 were included in the study. Questionnaires with 26 questions were evaluated in this study. Descriptive features, chi-square test and one-way ANOVA followed by Bonferroni’s post-hoc comparisons tests were performed in all statistical analyzes.Results: It was learned that 79.1% of the mothers were placing the thermometers under the armpit during measurement. Most of the mothers picked the normal body temperature as 35.5-36.4 ° C (57.8%). 74.8% of the mothers considered fever as a disease and 98.7% of the mothers thought that fever was harmful. Most of the mothers were considering the advices of doctors on reducing fever of children (48.7%). The most common intervention to reduce fever was to shower with warm water (73.5%). The most preferred antipyretic was paracetamol (76.1%). As the education levels increased, rates of showering with warm water and taking out the children's clothes were increasing significantly (p=0.027, p=0.025, respectively). Conclusion: In this study, it was seen that the mother's general knowledge about fever was inadequate and there were occasionally wrong attitudes and behaviors in order to reduce fever. We think that detailed information about fever given to the families by physicians will prevent unnecessary applications in this area.Öğe Çocukluk çağında tekrarlayan hışıltı: Bir üçüncü basamak hastane verileri(Yusuf Haydar ERTEKİN, 2018) Engin, Muhammet Mesut Nezir; Temizkan, Ramazan Cahit; Kilicaslan, Onder; Aslantas, Merve; Cangur, Sengul; Kocabay, KenanGiriş: Günümüzde çocuklarda tekrarlayan hışıltılar önemli bir problemdir. Tekrarlayan hışıltı şikayeti olan çocuk hastalarda önlenebilir risk faktörlerinin saptanması önemlidir. Risk faktörlerini sorgulayarak gerekli önerilerde bulunmak, hem tekrarlayan yatışların önüne geçebilir, hem de kalıcı bronş hasarından koruyabilir. Bu araştırmada, tekrarlayan hışıltı şikâyeti ile başvuran çocukların risk faktörlerinin değerlendirilmesi amaçlanmıştır. Yöntem: Bu kesitsel tipteki çalışmaya tekrarlayan hışıltısı olan 50 çocuk alındı. Çocukların geçmiş tıbbi hikâyeleri ve sosyodemografik özellikleri araştırıldı.Bulgular: Katılımcıların %60’ı (n=30) erkek, %40’ı (n=20) kadındır. Çocukların yaş ortalaması 49,1±48 (4-192) ay ve doğum kilosu 3227,2 ± 680,6 (1570 - 4190) gramdır. Doğum şekli (p=0,007), anne sütü alma durumu (p<0,001), aşılanma (p<0,001), atopik dermatit (p<0,001), çocuğun bakımı (p=0,003), annenin natal ve postnatal sigara kullanma durumu (p<0,001, p=0,007), ebeveyn ve kardeşlerde astım öyküsü (p<0,001), kırsal-şehir ikameti (p=0,021) ve evin rutubetli olma özellikleri (p=0,002) açısından tekrarlayan hışıltılı çocukların oranlarının anlamlı düzeyde farklı olduğu saptandı. Sonuç: Tekrarlayan hışıltı çocuklarda önemli bir sağlık problemidir. Hastaların tedavilerinde sosyodemografik ve çevresel risk faktörlerini önleyici yaklaşımlar göz önüne alınmalıdır.Öğe The Evaluation of the Genetic Variation Types of the Uridine Diphosphate Glucuronosyl Transferase 1A1 Gene by Next-Generation Sequencing and Their Effects on Bilirubin Levels in Obese Children(Mary Ann Liebert, Inc, 2024) Aslantas, Merve; Kilicaslan, Onder; Eroz, Recep; Kocabay, KenanBackground and Objectives: Obesity is a major nutritional problem with an increasing prevalence among children and adolescents. The uridine-diphosphate-glucuronosyl-transferase1A1 (UGT1A1) gene encodes the UDP-glucuronosyl transferase enzyme, converting the toxic form of bilirubin to a soluble, nontoxic form. There are yet to be studies on the evaluation of the UGT1A1 variant types detected by next-generation sequencing (NGS) and their effects on bilirubin levels in nonsyndromic obese children. Methods: Forty-five children with body mass index (BMI) >95 percentile (p) constituted the obesity group and fourteen healthy children with BMI <85p constituted the control group. Anthropometric, clinical features, and biochemical parameters were evaluated. Furthermore, the UGT1A1 gene was sequenced by NGS. Results: The obese patients had lower total, direct, and indirect bilirubin levels (p = 0.422, 0.026, and 0.568, respectively). In addition, obese patients had more genetic variations in the UGT1A1 gene compared with the control group (62.2% and 50%, respectively). We found that children with variations had higher total direct and indirect bilirubin levels compared with those without variation (p = 0.016, 0.028, and 0.015, respectively). Children diagnosed with obesity in the first two years of their life had fewer genetic variations and lower total bilirubin levels (p = 0.000 and 0.013, respectively). Conclusions: It is assumed that bilirubin can be protective against many chronic diseases. Although bilirubin levels are found to be lower in obese children compared with the control group, some variations in the UGT1A1 gene may be supported by raising bilirubin. We suggest that high bilirubin levels caused by those UGT1A1 variations may be protective against obesity and its many negative effects.Öğe Foreign Body Aspiration in Children; Duzce University Five-Years Results(Duzce Univ, Fac Medicine, 2021) Sav, Nadide Melike; Kilicaslan, Onder; Karaca, Seda Erisen; Tamturk, Cansu; Kabaklioglu, MuratObjective: Foreign body aspiration is a preventable cause of mortality and morbidity especially in younger than three years old children. The aim of this study is to determine the risk factors, causes and prognosis in patients with foreign body aspiration. Methods: In this study, laboratory and examination findings of 35 patients who underwent bronchoscopy, because of suspected foreign body aspiration, were retrospectively analyzed. Results: Of the 35 patients included in the study, 19 were boys and 16 were girls. The mean age was 3,2. The most causes of application were cough, and wheezing. Foreign body was detected in the right main bronchus in 62,8%, in the left main bronchus in 25,7%, in the trachea in 5,7% and in both bronchi in 5,7% of the patients. Conclusions: Early diagnosis and intervention significantly reduce the mortality and morbidity in foreign body aspirations. Prevention of foreign body aspirations is possible with the education of babysitters and family members.Öğe Lokal anestezik (prilokain) uygulamasına bağlı gelişen methemoglobinemi: Olgu sunumu(Yusuf Haydar ERTEKİN, 2018) Yalcin, Gulsen; Kilicaslan, Onder; Ozkan, Aybars; Kocabay, KenanGiriş: Sünnet, pek çok toplum tarafından dini, tıbbi ve de kültürel amaçlarla yapılan cerrahi işlemdir. Bu işlem esnasında kullanılan ajanlardan birisi olan prilokain sık kullanılan bir lokal anestezik ilaçtır. Literatürde normal dozda prilokainin uygulaması ile gelişebilen methemoglobinemi vakaları bildirilmiştir. Hemoglobinin çeşitli oksidatif streslerle oksitlenmesi sonucu, içeriğindeki iki değerli demirin, üç değerli haline dönüşmesine methemoglobinemi denir. Bu reaksiyon, dokuda hipoksemiye yol açar ve değişen derecelerde siyanozla kendini gösteren klinik tablo oluşur. Olgu Sunumu: İki buçuk aylık olgu, prilokain ile lokal anestezi uygulaması sonrası ortaya çıkan morarma şikayeti ve ölçülen oksijen satürasyonu %79 olması nedeniyle hastanemize doktor tarafından sevki yapıldı. Geliş fizik muayenesinde peroral bölgede, el ve ayaklarda siyanozu vardı. Hastaya lokal anestezik olarak prilokain verildiğinin öğrenilmesi, altta yatan solunumsal ve kardiyak bir nedenin bulunamaması ve kan gazında methemoglobin değerinin yüksekliği nedeniyle, ilaca bağlı methemoglobinemi düşünülerek metilen mavisi verilmesine karar verildi. Metilen mavisi 2 mg/kg oral verildi. Yaklaşık bir saat sonra siyanoz kayboldu. Kontrol methemoglobin düzeyi %2,7 olarak saptandı. Sonuç: Lokal anestezik uygulaması sonrası gelişen siyanozun ayırıcı tanısında methemoglobinemi mutlaka düşünülmeli ve erken süt çocukluğu döneminde yan etkileri daha az olan lokal anestezikler tercih edilmelidir. Bu olgu sunumunda prilokain ile lokal anestezi uygulaması sonrası ortaya çıkan methemoglobinemide ayırıcı tanı ve tedavi yöntemlerinin tartışılması amaçlandı.Öğe Re: Alpha-lipoic acid intoxication in an adolescent girl(Aves, 2021) Polat, Sinem; Kilicaslan, Onder; Sonmez, Feruza Turan[Abstract Not Available]Öğe Thrombosis risk of Alport syndrome patients: evaluation of cardiological, clinical, biochemical, genetic and possible causes of inherited thrombophilia and identification of a novel COL4A3 variant(Lippincott Williams & Wilkins, 2020) Eroz, Recep; Damar, Brahim H.; Kilicaslan, OnderTo evaluate cases with Alport syndrome for laboratory, radiological, ophthalmological, auditory tests, cardiological and inherited thrombophilia risk. Laboratory findings, abdominal and urinary ultrasonography, ophthalmological and auditory tests and cardiological examination of 21 Alport syndrome suspicious cases were performed. Also, collagen type IV alpha three chain (COL4A3) gene, four chain (COL4A4) gene and five chain (COL4A5) genes were sequenced by next-generation sequencing system. In addition, possible causes of inherited thrombophilia were evaluated. A novel (c.2806C> T/p.Gln936Ter) variation in COL4A3 gene was detected in three cases. Also c.221G>A/p.Arg74Gln variation in COL4A5 gene of two cases, c.4421C>T/p.Thr1474Met variation in COL4A4 gene of one case, c.665C>T/p.Pro222Leu variation in COL4A4 gene of one case and compound heterozygous c.4421C>T/(p.Thr1474Met) and c.665C>T/p.Pro222Leu variation in COL4A4 gene of one case were detected. Although 10 (47.6%) cases had microscopic hematuria, six (28.6%) cases had macroscopic hematuria, but there were not hematuria in five (23.8%) of cases. Three cases with variation carrier in COL4A genes and one case without variation carrier had vision problem. Also, one case with variation carrier in COL4A gene had hearing loss. All cases with variation carrier in COL4A genes exclude one had at least one cardiac problems. Also, all cases with variation carrier in COL4A genes had possible causes of inherited thrombophilia risk. In addition to developing risk of progressive kidney failure, sensorineural hearing loss and ocular abnormalities, Alport syndrome cases may have increasing cardiac problems and possible causes of inherited thrombophilia risk. Therefore, these cases should be regularly evaluated and followed for cardiac problems and inherited thrombophilia risk. Copyright (C) 2020 Wolters Kluwer Health, Inc. All rights reserved.
