Yazar "Kilic, Guven" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Effects of isotretinoin and acitretin on neuroregeneration in experimental spinal cord injury
    (Turkish Assoc Orthopaedics Traumatology, 2023) Kilic, Guven; Polat, Omer; Sensoy, Dogan; Soylu, Hakan
    Objective: This study aimed to determine whether isotretinoin and acitretin have beneficial effects on neural tissue damage following acute spinal cord injury. Methods: Thirty-six rats were randomly divided into 6 groups: control, sham spinal cord injury, spinal cord injury with isotretinoin 15 mg/ kg for 14 days, spinal cord injury with isotretinoin 15 mg/kg for 28 days, spinal cord injury with acitretin 10 mg/kg for 14 days, and spinal cord injury with acitretin 10 mg/kg for 28 days. The damage to the spinal cord was formed by the clip compression technique. A neurological evaluation was conducted on days 1, 14, and 28. All rats were sacrificed following the treatment period, and samples of their spinal cords were collected for histopathological analysis. Results: The inclined plane angle was significantly increased on the 14th and 28th days in the isotretinoin 15 mg and acitretin 10 mg groups, compared to the spinal injury group (P=.049 and P=.009, respectively). The Drummond-Moore criterion was significantly higher in the acitretin 10 mg group than in the injury group (P=.026). Cleaved Caspase-3 expression was similar in the isotretinoin 15 mg day 28 group and the control group (P > .05), but significantly decreased in the acitretin 10 mg 14th-day and acitretin 10 mg 28th-day groups compared to spinal injury isotretinoin 15 mg 14th-day and isotretinoin 15 mg 28th-day groups (P < .05). Conclusion: This was the first study elaborating that isotretinoin and acitretin reduced neuronal apoptosis and improved functional recovery after spinal cord injury. These neuroprotective effects might open a window of opportunity for patients.
  • Küçük Resim Yok
    Öğe
    Investigation of the Relationship Between Cervical Disc Herniations and Shoulder Complex Pathologies
    (Duzce Univ, Fac Medicine, 2024) Tuncer, Cengiz; Kilic, Rabia Tugba; Kilic, Guven; Karaduman, Zekeriya Okan; Arican, Mehmet; Akbari, Pouriya; Uludag, Veysel
    Objective: The aim of our study was to investigate whether there is a relationship between shoulder complex pathologies and cervical disc herniations. Materials and Methods: This study retrospectively included 524 patients with both dominant extremity shoulder and neck magnetic resonance examinations obtained from the information processing unit of Duzce University Faculty of Medicine between 01.08.2009-01.08.2023. The results were compared in Statistical Package for Social Sciences (SPSS). Results: A total of 524 patients, 153 (29.2%) males and 371 (70.8%) females, with a mean age of 51.17 +/- 13.70 (range, 13-93) years, were included in the study. According to the statistical analysis of our study, 410 of the participants had supraspinatus pathology, 234 had infraspinatus pathology, 243 had subscapularis pathology and 11 had teres minor pathology. In addition, a statistically significant relationship was found between other shoulder pathologies and herniations at the C4 -C5 and C5 -C6 disc level (p<0.05). Conclusions: In conclusion, even if there is a significant relationship between cervical disc herniations and shoulder pathologies, different methods should be developed for treatment algorithms and pain management. Evaluation of the cervical region should not be neglected in patient groups with shoulder pathologies.
  • Küçük Resim Yok
    Öğe
    Long-term Outcomes of Children with Myelomeningocele and the Quality of Life in Survivors
    (Duzce Univ, Fac Medicine, 2024) Cakmak, Hatice Mine; Onbas, Omer; Tuncer, Cengiz; Kocabay, Kenan; Kilic, Guven; Zamur, Cagatay; Sav, Nadide Melike
    Objective: Myelomeningocele, a condition that causes chronic health conditions and diminished quality of life, affects not just the children but also their families. Therefore, we comprehensively evaluated the data of 101 children with MMC (myelomeningocele) and aimed to compare the quality of life between children with MMC and their siblings. It is crucial to understand that children with MMS have a diminished quality of life with social and behavioral aspects and health issues, which can be emotionally challenging for them and their families. Methods: In this retrospective study, we collected data from electronic files, ensuring a comprehensive and accurate representation of the participants' medical history. To measure the quality of life, we used the KIDSCREEN 10 instrument, a widely recognized and validated tool in pediatric research. Results: Of the 101 children, 93 were survivors. Comparing the survivors (n=93) with their siblings, survivors had lower HRQoL (health-related quality of life) scores in subdimensions of physical well-being (p<0.001), relationships with family (p<0.001) Aand friends (p<0.001), Aschool performance and attention (p<0.001). On the other hand, the psychological wellness score was higher in survivors than in siblings (p<0.001). Most 44 (43.5%) had average mental capacity. The HRQoL score, a measure of the impact of health conditions on a person's overall well-being, was lower in the Chiari type 2 group than in the other survivors (p=0.035). Serum and folic acid levels did not correlate with HRQoL measures. Conclusions: This study illuminates the quality of life measures in MMC survivors and the Chiari type 2 group and utilizes new MRI findings, which provide groundbreaking insights into the health conditions and well-being of these populations. These findings are of utmost importance for medical professionals, researchers, and healthcare providers specializing in pediatric care and neurology, as they can significantly impact the treatment and care of these patients.