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Öğe A case successfully treated giant ventricular septal rupture after acute myocardial infarction(Springer, 2007) Kaya, Ahmet; Kaya, Yasemin; Ordu, Serkan; Özkökeli, Mehmet; Özhan, Hakan; Dağlar, Bahadır; Mehmet, Yazıcı…Öğe Comparison of the Effects of Dialysis Type on Right Heart Functions in Chronic Renal Failure Patients(2021) Yılmaz, Saadet; Düğeroğlu, Harun; Özbilen, Muhammet; Dereli, Seçkin; Yenerçağ, Mustafa; Kaya, Yasemin; Arıcı, YelizAim: The aim of this study was to compare the effects of dialysis type on right heart functionswith two-dimensional speckle tracking echocardiography (2D-STE).Material and Methods: A total of 53 patients who have peritoneal dialysis and hemodialysis,applied to cardiology and nephrology outpatient clinics, were included in the study. Those withleft heart failure, coronary artery disease, primary and secondary pulmonary hypertension,pulmonary embolism, deep vein thrombosis, moderate and severe heart valve failure and stenosiswere excluded from the study. Sociodemographic characteristics and biochemical parameters ofthe patients were recorded. Right heart functions of the patients were evaluated using 2D-STE.Results: There was no difference between groups with respect to age (p=0.496), the rate ofmale was higher in hemodialysis group (p=0.006). In comparison of 2D-STE measurements;right atrium (RA) maximum volume and RA minimum volume were significantly higher inhemodialysis patients (p=0.006, p=0.007, respectively). There were no difference between thegroups in RA maximum volume index, RA minimum volume index and tricuspid annular planesystolic excursion (TAPSE). RAS strain and RAA strain were significantly lower inhemodialysis patients (p=0.001, p=0.012, respectively). A positive correlation was foundbetween TAPSE and RA maximum volume in hemodialysis patients (r=0.484, p=0.036), andbetween TAPSE and RA minimum volume in peritoneal dialysis patients (r=0.486, p=0.025).Conclusion: Right ventricular functions were found to be similar in peritoneal dialysis andhemodialysis patients. It was observed that right atrial functions were better protected inperitoneal dialysis patients than hemodialysis patients.Öğe Evaluation of intestinal parasites and risk factors in patients applying to outpatient clinics with digestive system complaints in Ordu Province(Refik Saydam National Public Health Agency (RSNPHA), 2022) Karaman, Ülkü; Kaya, Yasemin; Özdemİr, Özlem; Enginyurt, Özgür; Gamsızkan, Zerrin; Çolak, Cemil; Yolalan, GamzeObjective: The aim of this study is to investigate the parasite prevalence, species and factors affecting parasite positivity in patients with digestive system complaints in Ordu Province in Turkey. Methods: 317 patients who presented with gastrointestinal complaints were included in the study. A questionnaire including; socio-demographic characteristics of the patients, lifestyle and digestive system complaints was applied. Cellophane band method, nativ-lugol, sedimentation and Modifiye kinyoun acid-fast methods were used for the diagnosis of fecal parasites. After the samples were prepared and stained, they were examined under a microscope. Results: Parasite positivity was detected in 205 (64.66%) of 317 patients. Blastocystis spp. constitutes 34.1%, 34.7% of Cryptosporidium spp and 16.1% of Entamoeba coli. The incidence of helminths was 2.8% and the incidence of protozoa was 97.2%. 73.7% of the parasite positive patients were in the age group of 40 years and over, 72.7% were women, 81% were married, 65.6% were middle-income, 48.3% had a primary and secondary education level. 58.5% lived in villages, 74.1% were housewives / unemployed. 77.6% of the parasite positive patients lived in the nuclear family, 51.2% were using city water, 93.7% were eating vegetables predominantly. In 9 (4.4%) of the patients with parasite positivity, no parasite was detected at the first examination, and it was detected in the 2nd and 3rd Bakers. The complaints of salivation in Entamoeba coli, Blastocystis spp. and Cryptosporidium spp, and allergy, rectal itching, drooling, increased appetite were significantly higher in Enterobius vermicularis (p <0.05). Conclusion: It has been observed that there is a high rate of parasites in patients presenting with digestive complaints. Mostly Blastocystis spp., Cryptosporidium spp species were observed in Ordu Province. Patients who present with the complaint of digestion, especially those whose complaints do not improve, should definitely be evaluated in terms of parasites and the preliminary diagnosis of parasitosis should not be immediately ruled out, even if the first stool examination is negative. © 2022,Turk Hijyen ve Deneysel Biyoloji Dergisi. All Rights Reserved.Öğe Lifestyle modification decreases the mean platelet volume in prehypertensive patients(Taylor & Francis Inc, 2009) Yazıcı, Mehmet; Kaya, Ahmet; Kaya, Yasemin; Albayrak, Sinan; Cinemre, Hakan; Özhan, HakanMean platelet volume (MPV) is an indicator of platelet activation. The present study was designed to investigate platelet function by measuring MPV, platelet count (PLC) and platelet mass (PLM) in prehypertensive (PHT) subjects. Additionally, we also evaluated the effects of lifestyle modification on platelet functions by measuring MPV, PLC and PLM. We selected 36 newly diagnosed PHT patients and 21 control subjects (BP 120/80 mmHg) matched for age and sex. Lifestyle modifications (weight loss, reduced sodium intake, increased physical activity, limited alcohol consumption and the Dietary Approaches to Stop Hypertension (DASH) diet) were recommended to PHT individuals for 20 weeks. At entry into the study, although PLM and PLC values were similar between study groups, MPV values were significantly higher in the PHT group than in the control group (respectively, 10.41 0.93 fl vs. 9.56 1.04 fl, p 0.01). Additionally, MPV was positively correlated with the systolic blood pressure (BP), body mass index (BMI) and insulin resistance (IR) in the PHT group (r: 0.41; p 0.02, r: 0.37; p 0.04, r: 0.35; p 0.05, respectively). Only age and PHT were found to be independent predictors of MPV after regression analysis. The program substantially lowered BP (net reductions in systolic and diastolic BPs of 16.2 and 8.7 mmHg, p 0.001, p 0.001, respectively). In addition, BMI, waist circumference (WC) and IR were significantly reduced in the PHT group (p 0.01, p 0.01, p 0.05, respectively). At the end of study, although PLM, PLC values were reduced in the PHT group, only the decrease in MPV reached statistical significance (respectively, 10.41 0.93 fl vs. 9.67 1.2 fl, p 0.01). In closing, to our best notice, our study is the first to display a significant increase in MPV in PHT subjects and to show a decrease in MPV by lifestyle modification after 20 weeks. As a result, we consider that decreased platelet activation with multi-aspect effects of lifestyle modification therapy might play an important role in reducing thrombotic risk in PHT patients.Öğe Ordu İlinde sindirim sistemi şikayeti ile polikliniklere başvuran hastalarda bağırsak parazitlerinin sıklığının ve risk faktörlerinin değerlendirilmesi(2022) Enginyurt, Özgür; Özdemir, Özlem; Karaman, Ülkü; Gamsızkan, Zerrin; Çolak, Cemil; Kaya, Yasemin; Yolalan, GamzeAmaç: Bu çalışmanın amacı Türkiye’de Ordu İlinde sindirim sistemi şikayeti ile başvuran hastalardaki parazit varlığını, türlerini ve parazit pozitifliğini etkileyen faktörleri araştırmaktır. Yöntem: Sindirim sistemi şikâyeti ile başvuran 317 hasta çalışmaya alınmıştır. Hastalara sosyo-demografik özelliklerini; yaşam tarzlarını ve sindirim sistemi şikayetlerini içeren anket uygulanmıştır. Dışkıda parazit tanısı için Selofanlı bant yöntemi, nativ-lügol, sedimantasyon ve Modifiye kinyoun asit-fast, yöntemleri kullanılmıştır. Örnekler hazırlandıktan ve boyandıktan sonra mikroskopta incelenmiştir. Bulgular: 317 hastanın 205 (%64,66)’inde parazit pozitifliği tespit edilmiştir. Bunlardan Blastocystis spp. %34,1 ini, Cryptosporidium spp %34,7 sini, Entamoeba coli %16,1 ini oluşturmaktadır. Helmint görülme oranı %2,8, protozoa görülme oranı %97,2 olarak tespit edilmiştir. Parazit pozitif çıkan hastaların %73,7’si 40 yaş ve üzeri olup %72,7’si kadın ve %81’i evli bireylerden oluşmuştur. Ayrıca %65,6’sı orta gelir düzeyinde, %48,3’ü ise ilk ve ortaokul eğitim düzeyindedir. Diğer taraftan %58,5’inin köylerde yaşadığı, %74,1’inin ev hanımı/işsiz olduğu görülmüştür. Ek olarak parazit pozitif çıkan hastaların %77,6’sı çekirdek ailede yaşadığını, %51,2’si şehir şebeke suyu kullandığını ve %93,7’si sebze ağırlıklı beslendiğini belirtmiştir. Diğer taraftan parazit pozitifliği tespit edilen hastaların 9 (%4,4)’unda ilk bakıda parazit tespit edilememiş ancak 2. ve 3. bakılarda tespit edilebilmiştir. Entamoeba coli, Blastocystis spp. ve Cryptosporidium spp de salya şikâyeti, Enterobius vermicularis‘de alerji, makat kaşıntısı, salya ve iştah artması şikayetleri anlamlı oranda daha yüksek bulunmuştur (p<0.05). Sonuç: Sindirim şikâyeti ile gelen hastalarda yüksek oranda parazit olduğu görülmüştür. Ordu İlinde en çok Blastocystis spp. ve Cryptosporidium spp. türlerine rastlanmıştır. Buna göre çalışmanın sonucu olarak sindirim şikâyeti ile başvuran (özellikle şikayetleri düzelmeyen) hastaların mutlaka parazit açısından da değerlendirilmesi ve ilk dışkı bakısı negatif gelse de parazitoz ön tanısının hemen ekarte edilmemesi önerilir.Öğe Prehipertansif hastalarda yaşam tarzı değişikliklerinin ekokardiyografik ve biyokimyasal parametreler üzerine etkisi(Düzce Üniversitesi, 2007) Kaya, Yasemin; Yazıcı, Mehmet; Cinemre, HakanGiriş: Son yapılan çalışmalara göre hipertansiyonun habercisi olan prehipertansiyonun prevelansının ülkemizde, dünyada oldukça fazla olduğu tespit edilmiş ve gittikçe artacağı tahmin edilmektedir. Yapılan çalışmalar sonucunda prehipertansif hastalarda diyastolik disfonksiyona rastlanmıştır ve prehipertansiyonun kardiyovasküler hastalık oluşumunun başlangıç noktası olduğu tahmin edilmektedir.Amaç: Araştırmamızda, prehipertansif hastalarda kan basıncını kontrol altına almak ve hipertansiyona gidişi önlemek için önerilen DASH diyeti ve egzersizin biyokimyasal, klinik ve ön planda diyastolik olmak üzere tüm ekokardiyografik parametrelere etkisinin belirlenmesi amaçlandı.Materyal Metod: Ek bir hastalığı olmayan, 20- 40 yaş arası prehipertansif (kan basıncı 120/80- 140/90 mmHg; 13E, 5K) ve normotansif (kan basıncı 120/80 mmHg altında; 6E, 7K) iki gruba DASH diyeti ve egzersiz verilerek tedavi öncesi ve sonrası klinik, laboratuvar değerlendirmesi ile diyastolik disfonksiyon için ekokardiyografik inceleme yapılarak, tedavinin bu parametreler üzerine etkisi ölçüldü.Bulgular: Sonuç olarak prehipertansif grubun vücut ağırlığı, GFR, homosistein ve OGTT açısından normotansif gruptan farklı olduğu; prehipertansif grubun DASH diyeti ve egzersiz tedavisine sistolik ve diyastolik kan basıncı, insülin düzeyi, insülin direnci, GFR ve homosistein açısından normotansif gruba göre daha iyi cevap verdiği; çalışma başında 17 prehipertansif hastanın 6'sında (%35.29) diyastolik disfonksiyon olduğu ve tedaviden sonra bunların 4 (%66.6)'ünün düzeldiği tespit edildi.Sonuç: DASH diyeti ve egzersiz tedavisi ile prehipertansif grupta normotansif gruba göre yüksek olan DKB ve SKB'ı, insülin ve homosisteinin düzeyleri ve insülin direnci etkin olarak tedavi edilebilmektedir..Prehipertansiflerde DASH diyeti ve egzersizin diyastolik disfonksiyon üzerine ne kadar etki ettiğini değerlendirmek için vaka sayısının fazla olduğu daha büyük bir çalışmaya ihtiyaç vardır.Öğe Relationship of Vitamin B12 and Vitamin D with IL-4, IL-10, TNF Beta in Obese Patients(Düzce Üniversitesi, 2023) Gülbay, Gonca; Kaya, YaseminObjective: We aimed to investigate the relationship of vitamin B12 and vitamin D with IL-4, IL-10 and TNF-Beta in obese patients.Methods: Serum IL-4, IL-10 and TNF-Beta levels were measured using kits based on the enzyme-linked immunosorbent assay (ELISA) principle.Results: The IL-10 level was found to be significantly lower in the low vitamin D group (p= 0.039). When vitamin B12 normal, vitamin B12 low and control groups were compared, a statistical difference was found between the groups in terms of IL-10 (p=0.002). As a result of post hoc analysis, the IL-10 level was found to be significantly lower in the vitamin B12 low group than in the vitamin B12 normal group (0.04). At the same time, vitamin B12 was statistically higher in the normal group (obesity positive) than in the control group (non-obese vit B12 normal) (p=0.001). A positive correlation was found between vitamin B12 and IL-10 (r= 0.203 p= 0.058).Conclusion: It has been shown that low levels of vitamin D and vitamin B12 in obese patients cause low levels of IL-10. It was also found that obesity caused an increase in IL-10 levels. No relationship was found between IL-4 and TNF-Beta and vitamin D and vitamin B12. Longer follow-up and studies in larger case populations are needed to better understand the effects of vitamin B12 and vitamin D on IL-4, IL-10 and TNF-Beta levels in obese patients.
