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Öğe The effect of amyloride and procaine on expression of heat shock protein 70 in rat retina(Assoc Research Vision Ophthalmology Inc, 2002) Tunç, Murat; Güven, A; Cam, M.; Kaya, M.; Aktan, G.; Ziyal, I.…Öğe End-tidal carbon dioxide levels under surgical drapes during local eye surgery: Retrospective study(Kuwait Medical Association, 2022) Yorulmaz, İlknur Suidiye; Esbah, A.U.; Ozlu, O.; Teberik, Kuddusi; Sözer, M.U.; Kaya, M.Objectives: To investigate the end tidal carbon dioxide pressure values in order to determine carbon dioxide accumulation under surgical drapes and it’s hemodynamic effects based on anesthetic and surgical records in eye surgeries under local anesthesia Design: Retrospective study Setting: Department of Anesthesiology and Reanimation, Düzce Medical Faculty, Düzce, Turkey Subject: The data were collected from anesthetic records of patients (n=42) who were followed with noninvasive capnography in the operating room at Düzce University Hospital during the period of January 2016 to December 2016. Systolic, diastolic and mean arterial pressure, operation time, heart rate, ST segment analysis, ETCO2 pressure, pulse oximetry values ??were recorded. Time periods were determined as: after the anesthesia and before drape closure (baseline level), at 10t h, 15th, 20th, 45th of the surgery and 5 minutes after drape removal. Intervention: Non-interventional Main outcome measure: C a rbon dioxide accumulation under drapes and it’s hemodynamic effects in eye surgeries under local anesthesia. Results: The comparisons were made with basal status and time periods statistically. No differences were found between mean arterial pressures, heart rates, arrhythmias and pulse oximetry values of pati ents between time periods. We observed significant di fferences for ETCO2 levels between basal and the other ti me periods, except when the drapes were removed (P=0.001). Conclusion: Routine mo nitorisation of ETCO2 with noninvasive capnograph yprovides early detection of CO2 accumulation and CO2 rich air breathing during ophthalmic surgery. © 2022, Kuwait Medical Association. All rights reserved.Öğe Inverted '?' technique without loss of skin tissue compared to classical open surgery technique in pediatric pilonidal sinus disease(Duzce University Medical School, 2021) Kabaklioğlu, M.; Kaya, M.Aim: Although the pilonidal sinus disease is commonly treated with surgical methods, search for optimal surgical procedures and minimally invasive methods continues. The aim of this study was to evaluate the inverted '?' technique which provides a tension-free closure with minimal tissue loss, by comparing with the classical open surgery technique. Material and Methods: Sixty-five patients, 37 (56.9%) male and 28 (43.1%) female, with a mean age of 15.85±1.82 years, admitted between January 2014 and October 2020 and underwent inverted '?' surgery and classical midline open surgery were retrospectively evaluated. Results: As an early postoperative complication, bleeding was observed in 2 (7.4%) patients in inverted '?' group and 3 (11.1%) patients had wound infection. The same complications were 4 (10.5%) and 4 (10.5%) in classical group, respectively. The time to return to full activities was statistically different between two groups (10.36±0.43 versus 11.30±0.93 days, p<0.001). During the follow-up period, 1 (3.7%) recurrence in the inverted '?' group and 9 (23.7%) recurrences in the classical group were statistically significant (p=0.037). Conclusion: The present technique aims to remove the pathological tissue that causes sacrococcygeal pilonidal disease by the subcutaneous surgical work area under the flap created through the '?' incision and to close it without tension, away from the midline without tissue loss. We believe that the operation involving the '?' incision and primary suture method should be considered as the first choice in the pediatric patient group because of being a simple and effective surgical technique for sacrococcygeal pilonidal disease treatment. © 2021, Duzce University Medical School. All rights reserved.Öğe May argyrophilic nucleolar organizer regions be used as a biomarker for the detection of the degree of ischemic damage instead of tunel in testicular torsion?(MDPI, 2021) Kabaklıoğlu, M.; Eroz, R.; Kaya, M.Background and Objectives: It is of great importance to obtain information about the severity of ischemic damage and duration of testicular torsion for an effective treatment strategy. Nucleolar-organizing regions (NORs) are sites of the ribosomal genes composed of ribosomal DNA and proteins. Post-silver staining NORs are termed “AgNOR”. Since AgNORs clearly reveals the self-renewal potential of cells damaged in ischemic events, we performed the current study. Materials and Methods: The study was carried out in four groups as control, sham, early, and late T/D. In the surgical groups, testes were corrected after a 4-h ischemia period. Testicular tissue samples were taken on the third day after detorsion in group 1, 2, 3, and on the tenth day after detorsion in group 4. TUNEL and silver stainings were applied to all samples. Results: The differences were significant among the groups for both mean AgNOR number and total AgNOR area/total nuclear area (TAA/TNA). Moreover, the differences between control and early torsion-detorsion (T/D), between control and late T/D, between sham and early T/D, between sham and late T/D, and between early T/D and late were statistically significant for AgNOR amount. Furthermore, statistically significant differences among the groups for an average number of apoptotic cells per tubule and the percentage of apoptotic tubule values were detected. Discussion: The apoptotic index gives the ratio of cells that are damaged and will die in a programmed way and cells that remain intact, rather than show the viability of the returning testicle. However, by measuring cells that regenerate with AgNOR, we can show not only those that survive but also cells that can repair themselves. Conclusion: AgNOR proteins are usable for the early observation of ischemic injury levels. The amount of AgNOR protein can enlighten us about the extent of testicular damage after T/D treatment. It may also help the physician in the development of effective treatment strategies for cases. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
