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Öğe Öğe N-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damage(Sage Publications Inc, 2014) Sarıtaş, Ayhan; Kandiş, Hayati; Baltacı, Davut; Yıldırım, Ümran; Kaya, Halil; Karakuş, Ali; Kara, İsmail HamdiObjective: This study is aimed to investigate the efficacy of erdosteine usage in acetaminophen-induced liver damage and to compare it with N-acetyl cysteine (NAC) in the treatment and prevention of liver toxicity due to overdose of acetaminophen. Methods: The rats were separated into the following six groups of seven rats each: control group; acetaminophen (1 g/kg, orally); acetaminophen (1 g/kg, orally) + erdosteine (150 mg/kg/day, orally); acetaminophen (1 g/kg, orally) + NAC (140 mg/kg loading dose, followed by 70 mg/kg, orally); NAC (140 mg/kg loading dose, followed by 70 mg/kg, orally); erdosteine (150 mg/kg/kg, orally), subsequently. In all the groups, potential liver injuries were evaluated using biochemical and hematological analyses, oxidant-antioxidant parameters and histopathological parameters. Results: In acetaminophen-treated group, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total oxidant status (TOS) in the blood, prothrombin time (PT) and international normalized ratio (INR) were significantly increased when compared with controls. However, total antioxidant capacity (TAC) and glutathione (GSH) levels were decreased in group treated with acetaminophen, when compared with control group. Levels of AST, ALT and TOS, PT and INR were decreased in groups treated with NAC and erdosteine after acetaminophen administration, but the levels of TAC and GSH were increased. Histopathological improvements were observed in the groups treated with NAC and erdosteine after acetaminophen administration. Conclusion: The present study demonstrated that, in the prevention of liver damage induced by acetaminophen intoxication, an early treatment with a single dose of erdosteine was beneficial instead of NAC administration.Öğe Satisfaction Levels Of Emergency Department Staff(Düzce Üniversitesi, 2013) Ocak, Tarık; Yorgun, Songül; Okumuş, Mehmet; Kaya, Halil; Çıkrıklar, Halil İbrahim; Duran, ArifAim: This study was performed to determine the satisfaction levels of health care workers whowork in emergency department of Izzet Baysal Bolu State Hospital and to investigate whetherthis survey is adequate to demonstarte employee satisfaction levels.Material and Methods: Fourty seven individuals included to the study who has worked inemergency department of Bolu Izzet baysal state hospital between 6th-15th of August in 2009.Results: Most of the study group were consisted of nurses. (%34). 68% of participants thinkthat employers are out of number, %53,2 of them think that they work more than weekly workingtime, and 72,3% of them stated that human resources are efficiently used in the hospital. 59,6%of the workers said that they have not been rewarded by the hospital administration. 89.4% ofthem stated that they have not been physically assaulted in last six months and 85.1% complaintof inadequate safety measures in working place.Conclusion: It would be useful making surveys among emergency department staff at regularintervals to make early interventions. This will also contribute to increased patient satisfactionand corporate successÖğe The Factors Affecting Mortality In Adults Due To High Voltage Electrical Injuries(Düzce Üniversitesi, 2013) Gökdemir, Mehmet Tahir; Söğüt, Özgür; Sayhan, Mustafa Burak; Kaya, HalilObjective: The purpose of this study was to investigate the factors that affect mortality in adultsdue to high voltage electric injury.Material and methods: Patients with electrical injuries admitted to the emergency departmentand intensive care unit between January 2009- December 2011 were retrospectively analyzed.The cases were evaluated mortality in relation to by age, gender, seasonal distribution, eventlocation, degree of burns, laboratory findings, ECG changes, falls from height, shock, intensivecare unit admission, development of sepsis.Results: One hundred fifty two cases were exposed to high-voltage electricity. Age group, sex,summer season, be processing industry, second and third degree burned, be unconsciousness,accompanied falls from height, evidence of shock, presence of ECG changes, admissionintensive care unit, have positive blood cultures, development of sepsis were significantly inrelation to mortality. Patients have 2nd degree burns, the presence of shock and sepsis wereindependent predictive factors in terms of mortality.Conclusion: In cases with high-voltage electrical injuries, male, elderly, be unconsciousness,development shock, 2nd and 3rd degree burns, development sepsis, fall from height, admissionintensive care unit were more mortally
