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Öğe Fibrous Dysplasia: (Because of 2 Cases)(Düzce Üniversitesi, 2008) Eser, Olcay; Aslan, Adem; Kaya, Eser; Şahin, Önder; Coşar, Murat; Eser, BetülAim: Fibrous dysplasia is a slow growing skeletal developmental anomaly in which particularly long tubular bones, ribs, skull and facial bones are involved. We aimed to present two cases diagnosed as fibrous dysplasia in our neurosurgey clinic. Case report: The first case was 11 year-old, male and had a craniofacial involvement with a rarely seen humerus involvement polyostotic fibrous dysplasia. The second case was 14 year-old, male and had only craniofacial involvement monostotic fibrous dysplasia. While medical treatment is used to reduce the symptomps of the disease, the surgical treatment is used to correct deformities in fibrous dysplasia. Cranioectomy was carried out for cosmetic purposes in case I, and due to prediagnosis of “osteom” in the Case II. The two cases were diagnosed as fibrous dysplasia as a result of clinical, histopathological and radiological examinations. Follow-ups for both cases were done. Result: Craniofacial involvement with humerus involvement is rarely seen in polyostotic fibrous dysplasia. We evaluated these two cases under the light of literatureÖğe Hepatit B Virus Enfeksiyonlu Hastalarda Renal Fonksiyonların Sintigrafik Değerlendirilmesi(Düzce Üniversitesi, 2008) Kaya, Eser; Demirdal, Tuna; Yüksel, ŞerefAim: Chronic hepatitis B virus (HBV) infection can induce nephropathy and major HBV antigens (HBcAg, HBeAg, HBsAg) and immune complexes responsible for its pathogenesis. The purpose of our study was to assess the renal function of patients with HBV infection by means of technetium diethylenetriamine pentaacetic acid (Tc99m DTPA) scintigraphy, in order to detect any early renal dysfunction, which might be related to nephropathy associated with HBV infection. Methods: Nineteen patients (10 male and 9 female with a mean age of 37.11±11.34 years, age range 25?62 years) with the diagnosis of HBV infections, and 16 healthy controls (8 male and 8 female with a mean age of 33.50±11.56 years, age range 24-55 years) were enrolled into the study. All subjects had no history of renal disease and treatment of HBV infection including interferon-alfa, pegylated interferon-alfa, lamivudine and adefovir. Blood urea nitrogen (BUN), urea and creatinine were analyzed. The renal perfusion, concentration and excretion were evaluated by Tc99m DTPA scintigraphy. The time to peak (TTP), peak activity (counts/second) (PA), clearance half time (T1/2) and percent contribution of each kidney to total function (differential function) were calculated. The glomerular filtration rate (GFR) was determined simultaneously by 3 methods; gamma camera uptake method (Gates, GFR), predicted creatinine clearance method (Cockcroft-Gault, CG-GFR), and Modification of Diet in Renal Disease (MDRD). The variables were compared between groups. Results: The mean values of patients’ parameters were as follows; right TTP:5.73±3.14 min, left TTP:5.52±2.09 min, right PA:884.78±214.85 cts/sec, left PA:889.52±252.68 cts/sec and right T1/2:17.84±6.89 min, left T1/2:14.51±8.59 min. Differential functions were 50.27±3.39% on the right side and 49.72±3.39% on the left side. In study group, Gates GFR value was 125.63±25.84 ml/min, CG-GFR:124.05±24.32 ml/min, MDRDGFR:113.15±24.70 ml/min/1.73 m2, BUN:14.57±5.05 mg/dl, urea: 27.37±10.24 mg/dl, and creatinine:0.73±0.18 mg/dl. The mean values of control group were as follows; right TTP:4.05±1.87 min, left TTP:2.93±1.14 min, right PA:819.25±260.48 cts/sec, left PA:796.75±176.94 cts/sec, and right T1/2:12.25±3.19 min, left T1/2:12.25±5.49 min. In control group, Gates GFR value was 109.75±39.03 ml/min, CG-GFR:104.62±39.67 ml/min, MDRD-GFR:89.68±34.15 ml/min/1.73 m2, BUN:11.37±4.47 mg/dl, urea:24.75±5.54 mg/dl, and creatinine:0.78±0.17 mg/dl. There were a statistical difference between patients and controls groups at right TTP value and left TTP value (p