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    Nanovesicles for intravenous drug delivery
    (Elsevier, 2022) Gültekin, Hazal Ezgi; Öner, Ezgi; İlhan, Miray; Karpuz, Merve
    Nanovesicular systems such as liposomes, niosomes, polymersomes, ethosomes, transfersomes, and extracellular vesicles are well-recognized carriers for the effective delivery and controlled release of drugs, genes, phytocompounds, imaging agents, and theranostics. With the intravenous administration of nanovesicles as targeted drug carriers, the bioavailability of active compounds is increased, while side effects at the sites of action are reduced. In this chapter, the nanovesicles are classified based on their structure and the type of drug to be loaded. The remarkable developments in the intravenous administration of nanovesicles are investigated and reviewed. In addition, usage areas of intravenous nanovesicles are highlighted regarding their applications in the treatment of diseases, gene therapy, and imaging. This chapter also provides insight into the place of intravenous nanovesicles in clinical applications by discussing their advantages, disadvantages, and potential challenges. © 2022 Elsevier Inc. All rights reserved.
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    Nanovesicles for tumor-targeted drug delivery
    (Elsevier, 2022) Karpuz, Merve; İlhan, Miray; Gültekin, Hazal Ezgi; Özgenç, Emre; Şenyiğit, Zeynep; Atlıhan Gündoğdu, Evren
    Cancer is one of the most important burdens for the health systems worldwide due to cancer-related deaths associated with late diagnosis and treatment toxicities. Diagnosis of cancer plays a critical role in reducing cancer death rates as it facilitates early prognosis and treatment. Current cancer treatment mainly includes the resection of tumor tissue, radiation treatment, and pharmaceutical treatment. Although various techniques, methods, and drugs are clinically used in cancer diagnosis and treatment, they are inadequate for early diagnosis and effective treatment. Therefore, several studies regarding cancer-targeted nanosized drug delivery systems and theranostic approach are performed. Nanovesicular systems, one of the most important types of drug delivery systems, are formulated for the effective delivery and controlled release of active compounds such as drugs, genes, phytocompounds, and imaging agents. In this chapter, different types of nanovesicles are reviewed after providing information about conventional cancer imaging and treatment. Furthermore, targeting mechanisms of nanovesicles for cancer are explained. Finally, some studies performed to develop the nanovesicles as the imaging, treatment, or theranostic system for cancer are summarized. © 2022 Elsevier Inc. All rights reserved.