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    EFFECTS OF LITHOSPERMIC ACID SUPPLEMENTATION AGAINST ACUTE EXERCISE-INDUCED OXIDATIVE STRESS IN RATS
    (Nobel Ilac, 2024) Coknaz, Hakki; Karaoglan, Esen Sezen; Ozgen, Ufuk
    Objective: The aim of the study was to investigate whether lithospermic acid (LSA), a naturally derived polyphenolic compound, supplementation could prevent acute exercise- induced oxidative damage to skeletal muscle tissue in the rats. Material and Method: Rats were randomly selected and divided into three groups (n= 7/group): Group 1Control group (non-exercise, UT), Group 2- Exercise group (exercise, T) and Group 3- Exercise+lithospermic acid group (exercise+lithospermic acid, T/LSA). At the end of the exercise protocol, the samples were removed from the right leg quadriceps muscle. Malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH) and superoxide dismutase (SOD) levels were measured in the muscle samples. Result: Compared to the UT group, malondialdehyde (MDA) and myeloperoxidase (MPO) activity levels in the muscle tissue of the T group significantly increased (p<0.001). MDA and MPO activity levels significantly decreased in the T/LSA group compared to the T group (p<0.05). Glutathione (GSH) and superoxide dismutase (SOD) activity levels significantly decreased in the T group compared to the UT group (p<0.05). GSH and SOD activity levels in muscle tissue significantly increased in the T/LSA group compared to the T group (p<0.05). No significant difference was found in MDA, MPO, GSH, and SOD levels between the UT group and T/LSA group (p>0.05). Conclusion: In conclusion, our study shows that oxidative activity levels in the muscle tissue of the T/LSA group decreased significantly in skeletal muscle-induced acute exercise in rats, so it can be considered that lithospermic acid has a protective effect against oxidative damage.