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  • Küçük Resim
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    Acil Serviste Basitleştirilmiş Pulmoner Emboli Ciddiyet İndeksi’nin Mortaliteyi Öngörmesinin Değerlendirilmesi
    (Düzce Üniversitesi, 2019) Akyol, Pınar Yeşim; Karakaya, Zeynep; Topal, Fatih Esad; Payza, Umut; Kuday Kaykısız, Eylem
    AMAÇ:Pulmoner emboli (PE) mortalite, morbidite ve hastane yatışının en önemlinedenlerinden biridir. Bu çalışmada pulmoner embolide Basitleştirilmiş PulmonerEmboli Ölçeği İndeksi (sPESI)  ilehastaların 3 aylık mortalite ilişkisini araştırmayı amaçladık.GEREÇVE YÖNTEM: Çalışmaya toplam 118 hasta dahil edildi. PE tanısından 3 ay sonraölen hastalar Grup 1 olarak tanımlandı. Diğer hastalar Grup 2 olaraktanımlandı. SPESI skoru hesaplandı ve kaydedildi. Bu skorlama sistemlerinin 3aylık mortalite üzerine etkisi araştırıldı.BULGULAR:Grup 1'de 31 hasta (% 26.3) ve Grup 2'de 87 hasta (% 73.7) vardı. HastalarınsPESI skorları incelendiğinde Grup 1 ve 2 arasında 3 aylık mortalite açısındanfark vardı. 3 aylık mortaliteyi öngörmede sPESI% 43.3 duyarlılık ve% 79.4özgüllük göstermiştir.SONUÇ:Acil serviste PE tanısı alan hastalarını risk profillerine göre ayırmak tedaviihtiyaçlarını belirlemek açısından önemlidir.ABSTRACTBACKGROUND:Pulmonary embolism (PE) is one of the major causes of mortality, morbidity andhospital admission. We aimed to investigate the association of the SimplifiedPulmonary Embolism Severity Index (sPESI) and mortality within 3 months.MATERIALSAND METHODS: A total of 118 patients were included in the study. Patients whodied within 3 months after PE diagnosis were defined as Group 1. Other patientswere defined as Group 2. The sPESI score was calculated and recorded. Theeffect of these scoring systems on 3-month mortality rate was investigated.RESULTS:  There were 31 patients (26.3%) in Group 1 and87 patients (73.7%) in Group 2. When the sPESI scores of the patients wereexamined, there was difference between Group 1 and 2 in terms of 3-month mortality.The sPESI had a sensitivity of 43.3% and a specificity of 79.4% for predicting 3-monthmortality. CONCLUSION:It is important to categorize patients diagnosed with PE in the emergencydepartment according to their risk profiles in terms of their treatment needs.
  • Küçük Resim
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    Evaluation of Chronic Subdural Hematoma Volume Calculated via Cavalieri’s Principle
    (2019) Karakaya, Zeynep; Sarıtaş, Ayhan; Akyol, Pınar Yeşim; Topal, Fatih Esad; Payza, Umut; Bilgin, Serkan
    Objective: Chronic subdural hematoma (CSDH) is a frequently encountered entity in neurosurgery. The objective of this study was to describe the use of unbiased Cavalieri principle to assess CSDH volume to total brain volume fraction (Percentage) and compare it with the clinical features of the patients. Methods: A total of 33 patients were included in the study. Computed tomography (CT) was acquired from the hospital-imaging database. The ratio of hematoma volume, brain volume, and hematoma volume to brain volume were measured via CT by two clinicians. Measurements were compared with clinical findings. Results: The sample consisted of 22 males and 11 females and mean age 67,27±12,63 years. The measured hematoma volume was 89,78 ± 54,13 cm3, the brain volume was 1329,91 ± 2098,35 cm3 and the percentage volume was 8,14 ± 4,92 cm3. The brain volume values of the cases with impaired consciousness were found to be statistically significant (p <0.05). Conclusions: It should be kept in mind that the bleeding volume of patients with vomiting may be higher.
  • Küçük Resim Yok
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    MEFV Gene Mutation Analysis in Children with Immunoglobulin A Vasculitis and Its Effects on Clinical Manifestations: A Big Series from a Tertiary Center
    (Galenos Publ House, 2024) Yildirim, Sema; Karakaya, Zeynep; Ozcay, Ozlem; Erguven, Muferet
    Aim: Immunoglobulin A vasculitis (IgAV) is the most common vasculitis of childhood, but its pathogenesis is largely unknown, despite evidence pointing to various environmental and genetic factors. We investigated the frequency of MEFV gene mutations that are considered in the pathogenesis and their effect on the clinical features of patients with IgAV. Methods: The study included 244 children diagnosed with IgAV, who underwent MEFV gene analyses. We recorded the demographic and clinical characteristics of the patients, along with their laboratory results. We grouped the patients based on the presence of MEFV gene mutations and MEFV variants. Results: At least one MEFV mutation was detected in 89 (36.5%) patients, with E148Q being the most common (n=31, 34.8%). Age at diagnosis and the frequency of hematuria and recurrence were significantly greater among patients with MEFV mutations (p=0.043, p=0.008, and p=0.009, respectively). Serum IgA levels were significantly higher in patients with the M694V mutation (p=0.040). Conclusion: The presence of MEFV mutations, particularly E148Q and M694V, could be associated with the development and clinical course of IgA vasculitis.