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  • Küçük Resim
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    Evaluation of Chronic Subdural Hematoma Volume Calculated via Cavalieri’s Principle
    (2019) Karakaya, Zeynep; Sarıtaş, Ayhan; Akyol, Pınar Yeşim; Topal, Fatih Esad; Payza, Umut; Bilgin, Serkan
    Objective: Chronic subdural hematoma (CSDH) is a frequently encountered entity in neurosurgery. The objective of this study was to describe the use of unbiased Cavalieri principle to assess CSDH volume to total brain volume fraction (Percentage) and compare it with the clinical features of the patients. Methods: A total of 33 patients were included in the study. Computed tomography (CT) was acquired from the hospital-imaging database. The ratio of hematoma volume, brain volume, and hematoma volume to brain volume were measured via CT by two clinicians. Measurements were compared with clinical findings. Results: The sample consisted of 22 males and 11 females and mean age 67,27±12,63 years. The measured hematoma volume was 89,78 ± 54,13 cm3, the brain volume was 1329,91 ± 2098,35 cm3 and the percentage volume was 8,14 ± 4,92 cm3. The brain volume values of the cases with impaired consciousness were found to be statistically significant (p <0.05). Conclusions: It should be kept in mind that the bleeding volume of patients with vomiting may be higher.
  • Küçük Resim Yok
    Öğe
    MEFV Gene Mutation Analysis in Children with Immunoglobulin A Vasculitis and Its Effects on Clinical Manifestations: A Big Series from a Tertiary Center
    (Galenos Publ House, 2024) Yildirim, Sema; Karakaya, Zeynep; Ozcay, Ozlem; Erguven, Muferet
    Aim: Immunoglobulin A vasculitis (IgAV) is the most common vasculitis of childhood, but its pathogenesis is largely unknown, despite evidence pointing to various environmental and genetic factors. We investigated the frequency of MEFV gene mutations that are considered in the pathogenesis and their effect on the clinical features of patients with IgAV. Methods: The study included 244 children diagnosed with IgAV, who underwent MEFV gene analyses. We recorded the demographic and clinical characteristics of the patients, along with their laboratory results. We grouped the patients based on the presence of MEFV gene mutations and MEFV variants. Results: At least one MEFV mutation was detected in 89 (36.5%) patients, with E148Q being the most common (n=31, 34.8%). Age at diagnosis and the frequency of hematuria and recurrence were significantly greater among patients with MEFV mutations (p=0.043, p=0.008, and p=0.009, respectively). Serum IgA levels were significantly higher in patients with the M694V mutation (p=0.040). Conclusion: The presence of MEFV mutations, particularly E148Q and M694V, could be associated with the development and clinical course of IgA vasculitis.