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    Effects of Metoprolol on Experimental Spinal Cord Ischemia-Reperfusion Injury in Rats
    (2021) Karahan, Suleyman Caner; Yaman, Serap Özer; Ercin, Mustafa Emre; Hızıroğlu, Sabahattin; Güvercin, Ali Rıza; Yazar, Uğur
    Aim: The aim of this study was to investigate the neuroprotective effect of metoprolol and its efficacy in reducing lipidperoxidation levels in the spinal cord ischemia-reperfusion model in rats.Material and Methods: Twenty (20) Sprague-Dawley female rats weighing between 220 gr and 280 gr were randomlydivided into 3 groups. Only laparotomy was performed in the control group, and the aorta abdominalis was revealed. Inthe groups other than the control group, clip compression was applied to the aorta abdominalis for 45 minutes. Theischemia group was not given any medication. Metoprolol was administered intraperitoneally at 0.5 mg/kg to themetoprolol group. Motor examination was made according to Tarlov scale at the 1st and 24th hours and then, spinalcords of all rat models were removed. Spinal cord tissue samples were collected for histopathological examination andfor determining malondialdehyde (MDA) level. All rats were sacrificed by draining blood after their motorexaminations.Results: According to motor examination findings at the 1st and 24th hours, metoprolol resulted in a statisticallysignificant improvement in recovery (p=0.045). Histopathological examinations revealed that metoprolol contributed toneurological recovery by reducing neuronal necrosis. MDA levels, which is an indicator of lipid peroxidation, weresignificantly lower in the metoprolol group when compared to the ischemia group (p=0.001).Conclusion: Metoprolol was found to be significantly effective in reducing and/or preventing spinal cord ischemiareperfusion injury.