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Öğe Argyrophilic nucleolar organizing regions in patients with Xeroderma Pigmentosum Group E(Wiley, 2021) Karagun, Ebru; Eroz, Recep[Abstract Not Available]Öğe Assessment of the Effect of Psoriasis and Methotrexate Treatment on Liver Stiffness by ARFI Imaging(Duzce Univ, Fac Medicine, 2023) Guclu, Derya; Karagun, Ebru; Unlu, Elif Nisa; Oktay, Mehtap; Pasin, OzgeObjective: To investigate whether psoriasis and methotrexate used in its treatment cause liver fibrosis and eventually to evaluate the safety of methotrexate in treatment.Methods: 44 cases were included in the study. Methotrexate-using (group 1, n=14) and methotrexate-not-using (group 2, n=13) psoriasis patients were compared retrospectively with a healthy control group (group 3, n=17) according to mean shear wave rates obtainedResults: Mean shear wave velocities were calculated as 2.57 & PLUSMN; 1.13 m/sec in the patients using methotrexate, 2.31 & PLUSMN; 1.16 m/sec in the patients who did not use methotrexate, and 1.56 & PLUSMN; 0.62 m/sec in the healthy control group. While the average shear wave velocity of the 3rd group was found to be significantly lower than that of the 1st and 2nd groups (p=0.032; p=0.012), no significant difference was observed between the 1st and 2nd groups (p=0.755).Conclusions: Shear wave imaging with ARFI quantification findings revealed no evidence that methotrexate therapy is associated with liver fibrosis in psoriasis patients and we think that the increase in liver tissue stiffness in patients using methotrexate for psoriasis is secondary to the inflammatory process caused by psoriasis itself rather than methotrexate.Öğe Decreased Oxidative Stress Markers in Patients with Active and Generalized Vitiligo(Duzce Univ, Fac Medicine, 2022) Ozcan, Yunus; Karagun, Ebru; Alpay, MerveObjective: Oxidative stress has been shown to play a role in the pathophysiology of several diseases, making it a popular yet contentious research area. There is some evidence that selective melanocyte destruction may have developed in vitiligo patients as a result of elevated oxidative stress. The purpose of this study is to investigate the impact of oxidative stress on lipid, protein, and nucleic acid metabolism in vitiligo patients. Methods: We used ELISA method to measure serum oxidative stress markers in patients with generalized vitiligo who had newly formed lesions in the previous three months but had not been treated, as well as healthy controls. Malondialdehyde (MDA), 2,4-dinitrophenyl hydrazone (DNPH), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and uncoupling protein 2 (UCP2) levels were measured to assess the influence of reactive oxygen derivatives on lipid, protein, nucleic acid metabolism, and mitochondria, respectively. Results: The study included 84 participants, including 64 active generalized vitiligo patients and 20 healthy controls with similar age and gender distribution. In the serum of vitiligo patients, we detected significantly lower levels of MDA (ng/mL, mean +/- SD=12 +/- 19; 33.4 +/- 35.9), DNPH (ng/mL, mean +/- SD=2 +/- 3.1; 6 +/- 7.4), 8-OHdG (ng/mL, mean +/- SD=11.7 +/- 17.9; 32.7 +/- 37) and UCP2 (ng/mL, mean +/- SD=8.7 +/- 13.7; 21.5 +/- 28.4. Conclusions: Although there is significant evidence that oxidative stress plays a role in the pathophysiology of vitiligo, the studies should be interpreted cautiously due to the heterogeneity in the methodology, complexity of the oxidative stress pathways, and potential publication bias. Large-scale studies using a standardized methodology are required to determine how significant oxidative stress is in the core pathophysiology of vitiligo and which pathways it primarily affects.Öğe Dermatoscopic Features of Early Erythema Chronicum Migrans(Croation Dermatovenerological Soc, 2023) Ozcan, Yunus; Takir, Sumeyye Gunes; Karagun, Ebru; Uyar, Belkiz[No abstract available]Öğe Effects of climate and air pollution factors on outpatient visits for eczema: a time series analysis(Springer, 2021) Karagun, Ebru; Yildiz, Pinar; Cangur, SengulEczema resulting from external and internal factors accounts for the biggest global burden of disability owing to skin disease. This study aimed to determine an association between environmental factors and outpatient clinic visits for eczema. We collected data on dermatology clinic outpatient visits for eczema between January 2013 and July 2019. Data concerning environmental factors during this period were collated using national air quality network and air monitoring measurement parameters, namely barometric pressure, relative humidity, air temperature, and air pollutant concentrations, such as sulfur dioxide (SO2) and particulate matter (PM10). A distributed lag nonlinear model was used to investigate the relationship among eczema, environmental factors, and lagged effects. In total, 27,549 outpatient visits for eczema were recorded. In both single-factor and multiple-factor lag models, the effects of a 10-mu g/m(3)increase in PM(10)and SO(2)values had significantly positive effects on the number of daily outpatient visits over a total 5 days of lag after adjusting for temperature, the number of daily outpatient visits increased with 0.87%, 7.65% and 0.69%, 5.34%, respectively. Relative humidity (RR = 1.3870, 95% CI 1.3117-1.4665) and pressure (RR = 1.0394, 95% CI 1.0071-1.0727) had significantly positive effects on the number of daily outpatients in single-factor lag models. However temperature had a significantly negative effect on them in the number of daily outpatients (RR = 0.9686, 95% CI 0.9556-0.9819). Exposure to air pollution exacerbated eczema. Outpatient visits for eczema were found to have strong positive associations with changes in PM(10)levels.Öğe Levels of TNF-alpha, IL-6, IL-17, IL-37 cytokines in patients with active vitiligo(Taylor & Francis Ltd, 2021) Karagun, Ebru; Baysak, SevimObjectives Vitiligo is an autoimmune disease, and its pathogenesis involves changes in cytokine levels in the affected patients. Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-17 from pro-inflammatory cytokines, IL-37 in a recently detected anti-inflammatory activity. The aim of our study was to determine serum TNF-alpha, IL-6, IL-17, IL-37 levels in patients with vitiligo to understand their possible roles in the disease etiology and to compare the results with the healthy controls. Methods The study included 48 generalized vitiligo patients who were diagnosed with vitiligo, had an increase in the lesions within the last 3 months, and did not receive any systemic or topical treatment during this period; furthermore, 18 healthy controls were included. Results Patient group: n = 48, mean age = 30.48 +/- 9.86 years; control group: n = 18, mean age = 28.27 +/- 9.66 years. Individuals in the patient group had significantly higher serum levels of IL-37(t = 3.90, p < .001), IL-6 (t = 3.39, p < .05), IL-17 (t = 2.08, p < .05), and TNF-alpha (t = 4.69 p < .001) than in the control group. Conclusion The high levels of (pro-anti) inflammatory cytokines in vitiligo patients draw attention to the importance of cytokines in the pathogenesis of the disease.Öğe Novel mutation identified in the DDB2 gene in patients with xeroderma pigmentosum group-E(Wiley, 2020) Karagun, Ebru; Eroz, Recep; Gamsizkan, Mehmet; Baysak, Sevim; Eyup, Yavuz; Ozcan, YunusBackground Xeroderma pigmentosum (XP) is a rare photosensitive syndrome, which is divided into eight complementation groups (XP-A to XP-G and XPV) and characterized by skin cancers diagnosed at early age. A family of seven members (age range between 5 and 47 years) with carriers of the novel nonsense mutation that causes XP-E type were included in the current study. Methods DNA was isolated from peripheral blood samples of the proband, and cancer predisposition genes were sequenced with next-generation sequencing. The demographic features and the laboratory, clinical, and histopathological findings of patients were evaluated. Results In the proband, squamous cell carcinoma was first diagnosed in the right-eye cornea at the age of 13 years and then in the left-eye cornea at the age of 15 years. Later, the patient was diagnosed with basosquamous cell carcinoma on the dorsum of the nose at the age of 18 years. After genetic analysis, a novel nonsense c.1063C>T(p.Arg355Ter) pathogenic variation that causes XP-E type was detected as homozygous in the DDB2 gene of the proband and her siblings, 11 and 5 years of age, and as heterozygous in her parents and a 22-year-old brother. Conclusion Because of the occurrence of early termination codon, truncated nonfunctional proteins or proteins with deleterious loss or gain-of-function activities are synthesized in nonsense mutation. Thus, to avoid the development of pathological lesions, it is important that such patients with nonsense mutation stay away from agents that might cause DNA damage and develop an appropriate lifestyle according to this condition.
