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Öğe Abnormal ECG Findings In Turkish Adults: An Epidemiologic Observational Study(Elsevier Science Inc, 2013) Karabacak, Ahmet; Türker, Yasin; Tibilli, Hakan; Türker, Yasemin; Albayrak, Sinan; Ekinözü, İsmail; Özhan, Hakan…Öğe Amount of ST wave resolution in patients with and without spontaneous coronary reperfusion in the infarct -related artery after primary PCI: an observational study(Turkish Soc Cardiology, 2012) Erden, Emine Çakcak; Erden, İsmail; Türker, Yasin; Aslantaş, Yusuf; Yalçın, Sübhan; Karabacak, AhmetObjective: In patients with ST-elevation myocardial infarction (STEN) undergoing primary percutaneous coronary intervention (PCI), a patent infarct-related artery (IRA) on initial angiography was associated with better angiographic results and improved prognosis compared with patients without spontaneous reflow. The role of systematic emergency PCI in patients with spontaneous reperfusion during myocardial infarction is debated. We compared the amount of ST wave resolution (STR) in patients with and without spontaneous coronary reperfusion (SCR) in the infarct related artery. Methods: This study was designed as an observational cohort study. One hundred sixty-one consecutive patients (121 males, 40 females, with a mean age of 56 10 years) who had STEMI and treated with primary PCI without previous thrombolytic therapy were included in the study. All patients were treated with primary PCI within 12 hours from the onset of the symptoms and had stent implantation in the culprit lesion. ST wave resolution was measured as percent resolution of ST segment elevation from electrocardiogram (ECG), before and after PCI, classified as complete (>70%), partial (30% to 70%), or absent (<30%). SCR was defined as a TIMI grade III flow in the IRA on baseline coronary angiogram. The amount of ST wave resolution (STR) in patients with and without SCR in the IRA was compared. We used Chi-square test, Student's t-test and the Mann-Whitney U test for statistical analysis. Results: At the baseline coronary angiography 40(25%) patients had SCR and 121 patients (75%) had TIMI flow grade 0, 1 or 2 (non-SCR group). ST segment resolution amount was significantly higher in patients without SCR (53 +/- 17 versus 13 +/- 23 mm; p<0.001). In fact; in five patients whom had patent infarct related artery in initial angiography, ST segment elevation increased according to pre-PCI ECG. Conclusion: Mean ST wave resolution was lower in patients with spontaneous coronary reperfusion who were treated with primary PCI compared to their counterparts who did not have spontaneous coronary reperfusion on initial coronary angiography. (Anadolu Kardiyol Derg 2012; 12:30-4)Öğe Association of omentin Val109Asp polymorphism with coronary artery disease(Turkish Soc Cardiology, 2014) Yörük, Ümit; Yaykaşlı, Kürşat Oğuz; Özhan, Hakan; Memişoğulları, Ramazan; Karabacak, Ahmet; Bulur, Serkan; Kaya, ErtuğrulObjective: Coronary artery disease (CAD) is the most important morbidity and mortality disease in the world. It is also one of the leading causes of death in Turkey. Omentin, a recently found adipocytokine, is reported to regulate insulin sensitivity. It has anti-inflammatory properties and is inversely associated with CAD. Omentin gene polymorphism in patients with CAD has not been studied yet. The aim of this study is to investigate the relationship between omentin Val109Asp polymorphism and CAD. Methods: This is an observational study on genetic association. 157 consecutive patients who had undergone coronary angiography were included in the study. Seventy-five of them had CAD and the rest serves the control group. Val109Asp polymorphism was analyzed and compared. Chi-square test was used in comparison of genotype frequencies, whereas ANOVA and chi-square tests were used in comparison of clinical characteristics according to the genotypes. Results: There was no significant difference between CAD patients and control subjects regarding omentin Val109Asp polymorphism. However, a 2.5 fold increase in Val/Val (homozygous mutant) genotype was detected in patients with CAD. The OR (80% Cl) for Val/Val genotype was 3.46 (1.14-10.49). Conclusion: Although no significant difference was detected regarding omentin Val109Asp polymorphism, Val/Val genotype frequency was found to be more in patient group than control group. In conclusion, it may be speculated that Val/Val genotype increases the tendency for CAD, but this experiment should done with larger population to clarify this issue.Öğe Correlation between the body fat composition and high sensitive C-reactive protein in Turkish adults(2012) Aydın, Mesut; Dumlu, Talha; Alemdar, Recai; Kayapınar, Osman; Celbek, Gökhan; Karabacak, Ahmet; Atılgan, Zuhal Arıtürkobjectives. Te adipose tissue is an active immune organ. High sensitive C-reactive protein CRP (hs-CRP) is a strong independent predictor of a possible future myocardial infarction and stroke, and it has also been shown to be related to the sub clinical atherosclerosis. Te aim of this study was to investigate the relation between the body fat composition, metabolic syndrome, and the hs-CRP plasma levels. Methods. Total 246 consecutive Turkish subjects, admitted to the internal medicine clinic with the diagnosis of diabetes mellitus, insulin resistance or metabolic syndrome, were included into the study. Te total body fat composition was measured in every participant with a commercially available bio-impedance meter. Te hs-CRP levels, body composition parameters, and biochemical variables were compared. Results. Te hs-CRP levels increased in parallel with the body weight in Turkish subjects. Tis increase was significant especially in the women. Te waist circumference, body mass index (BMI), and body composition variables (visceral fat level, total body fat, and total body muscle mass) were significant correlates of the hs-CRP. Te waist circumference and BMI were independent predictors of the hs-CRP. Conclusion. Te waist circumference, BMI, and body composition variables (visceral fat level, total body fat and total body muscle mass) were significant correlates of the hs-CRP in Turkish adults. Body weight control may account for an important target especially in patients with the metabolic syndrome.Öğe Düzce ili yığılca ilçesinde patolojik elektrokardiyografi bulgularının prevelansı(Düzce Üniversitesi, 2012) Karabacak, Ahmet; Türker, YasinAmaç Aterosklerotik kardiyovasküler hastalıklar (KVH) tüm dünyada en sık ölüm sebebidir. Anormal elektrokardiyografi (EKG) bulguları, kısa dönem kardiyovasküler risk için öngördürücüdür. Türk yetişkinlerinde anormal EKG bulgularının sıklığı ile ilgili eksik olan ulusal epidemiyolojik verilere katkı sağ-lamayı amaçladık.Yöntem Türkiye?nin batı Karadeniz bölgesindeki 18 yaş üstü Türk yetişkinlerinde anormal EKG bulguları ile aritmilerin prevelansı araştırıldı. Bu büyük epidemiyolojik gözlemsel kohort çalışmada 2239 kişi 1 kez çekilen 12 derivasyonlu istirahat EKG ile tarandı. EKG?de patolojik Q dalgaları, eksen sapması, yüksek R amplitüdü, ST-T değişiklikleri, atrioventriküler (AV) bloklar, interventriküler (İV) bloklar, aritmiler ve düşük QRS gerilimi gibi EKG parametreleri değerlendirildi. EKG bulguları, Minnesota kodlama sistemine göre sınıflandırıldı. Bulgular Ortalama yaş 50 ± 15 (18-92 yaş) olarak saptandı. Yaş ayarlaması yapılarak 40 yaş üzerindeki bireylerde anormal EKG ile aritmilerin prevelansı sırasıyla; patolojik Q dalgası % 2.06, sol aks sapması % 9.64, yüksek R amplitüdü % 6.57, ST segment depresyonu % 2.01, T negatiflikleri % 3.25, sol dal bloğu % 2.63, ekstrasistoller % 3.26 ve atrial fibrilasyon % 2.01 olarak saptanmıştır. Sonuç Bu gözlem, son 20 yılda Türkiye?de arteriyel hipertansiyon, koroner arter hastalığı ile atrial fibrilasyon prevelansının artış eğiliminde olduğunu göstermektedir. Anahtar kelimeler Elektrokardiyografi, epidemiyoloji, Türk yetişkinleriÖğe Impact of Body Mass Index on Left Ventricular Diastolic Dysfunction(Wiley, 2012) Çil, Habib; Bulur, Serkan; Türker, Yasin; Kaya, Ahmet; Alemdar, Recai; Karabacak, Ahmet; Özhan, HakanBackground: The prevalence of obesity is increasing in the developed and developing world. It is an independent risk factor for heart failure. Left ventricular (LV) diastolic dysfunction has been demonstrated to be a strong predictor of heart failure. In the present study we aimed to assess the impact of body weight on LV diastolic function. Methods: The study was conducted on 2,228 participants (1,424 women, 804 men with a mean age of 49). Traditional and tissue Doppler echocardiographic examination were performed in all of the participants. The demographic and echocardiographic data were compared. Multivariate logistic regression analysis was used to assess the independent predictors of association of LV diastolic function. The study sample was divided into four groups: group 1 (body mass index [BMI] < 25.0 kg/m2), group 2 (BMI 25.029.9 kg/m2), group 3 (BMI = 3039.9 kg/m2), and group 4 (BMI = 40 kg/m2). Results: Septal E was significantly lower in groups 2 and 3 compared to group 1 (P = 0.003). Septal A and septal A were significantly higher whereas septal E and lateral E were significantly lower in the groups 2, 3, and 4 compared to the normal weight group (P < 0.001). Lateral A, deceleration time, and ejection time were significantly higher in obese when compared to the normal weight (P = 0.025, P < 0.001, and P = 0.009, respectively). The E/E ratio was significantly higher in groups 2, 3, and 4 compared to the group 1 (P < 0.001). Logistic regression analysis revealed that age, BMI (OR = 1.060 [95% CI = 1.040 and 1.080]; P < 0.001), hypertension, and diabetes mellitus were independent predictors of LV diastolic dysfunction. Conclusion: BMI is an independent predictor of LV diastolic dysfunction along with age, hypertension, and diabetes mellitus. (Echocardiography 2012;29:647-651)Öğe Pathologic Echocardiographic Findings among Turkish Adults: an Epidemiologic Observational Study(Duzce Univ, 2015) Yalçın, Sübhan; Türker, Yasin; Özhan, Hakan; Aslantaş, Yusuf; Türker, Yasemin; Ekinözü, İsmail; Karabacak, AhmetPurpose: Echocardiography is used in diagnosis and follow-up of congenital and acquired cardiovascular disease and in assessment of cardiac structure and function. There are many studies that used echocardiography to evaluate cardiovascular diseases but the number of the epidemiological studies is scarce. The aim of this study is to research the frequency of cardiovascular diseases detected by echocardiography. Methods: The study was conducted in May and June, 2010 in the Social health center located in Yigilca, the north-east of Duzce. 400 adult subjects (>17 years old) from each family physician representatively stratified for sex, age and for rural-urban distribution were randomly assigned and invited to participate the study. A total of 2231 subjects with a mean age of 50 +/- 15 (age range 18 to 92) were interviewed. Data were obtained by measurements and echocardiography. Results: There was significant difference between men and women in all measurements except deceleration time (DT), Ejection Time (ET) and pulmonary artery pressure PAP values (p<0.01). The prevalence of diastolic dysfunction (DD) was 67.6%. There was no significant difference between men and women (p>0.05). The prevalence of ascending aorta dilatation was 3.2%, heart failure was 1.7%, bicuspid aorta was 0.8%, aortic stenosis was 3.4%. Aortic regurgitation, tricuspid regurgitation and pulmonary regurgitation was detected in 38.9%, 52.8%, 12.4%. Conclusion: Because it is a portable and cheap method, the rate of using echocardiography in assessment of cardiovascular diseases increased. It should not ignore that by early detection and treatment, progression of diseases can be prevented and life quality of patients can be improved. Further epidemiological studies are needed to get more information about this issue.Öğe Pathologic Echocardiographic Findings In Turkish Adults: An Epidemiologic Observational Study(Elsevier Science Inc, 2013) Yalçın, Sübhan; Türker, Yasin; Özhan, Hakan; Aslantaş, Yusuf; Türker, Yasemin; Ekinözü, İsmail; Karabacak, Ahmet…Öğe Türk Erişkinlerde Patolojik Ekokardiyografi Bulguları: Epidemiyolojik Gözlemsel Çalışma(2015) Yalçın, Sübhan; Türker, Yasin; Özhan, Hakan; Aslantaş, Yusuf; Türker, Yasemin; Ekinözü, İsmail; Karabacak, AhmetAmaç: Ekokardiyografi konjenital ve edinsel kalp hastalıklarının tanısında ve izleminde kullanılan, kardiyak yapı ve işlevlerin değerlendirildiği bir tanı yöntemidir. Günümüze kadar yapılmış, kardiyovasküler hastalıkların ekokardiyografi ile değerlendirildiği birçok çalışma bulunmakla beraber epidemiyolojik araştırmanın yapıldığı geniş ölçekli çalışma sayısı kısıtlıdır. Bu çalışmanın amacı, ekokardiyografi ile saptanabilen kardiyovasküler hastalıkların toplumdaki sıklığını araştırmaktır. Yöntem: Çalışmaya, Düzce ilinin kuzey-doğusundaki Yığılca ilçesinde yaşayan, her aile hekimini temsilen cinsiyet, yaş, kentsel-kırsal dağılım açısından randomize olarak seçilmiş 400er kişi ( 17 yaş) davet edildi. Ana çalışma grubunu ortalama yaşı 5015 (18-92 arası) olan 2231 katılımcı oluşturdu. Değerlendirmeler Mayıs-Haziran 2010 tarihlerinde ilçe sosyal sağlık merkezinde yapıldı. Veriler; ölçümler, hastaların özgeçmiş öyküleri ve ekokardiyografi (EKO) aracılığı ile toplandı. Bulgular: Ekokardiyografik ölçümler sonucunda, veriler cinsiyete göre değerlendirildiğinde deselerasyon zamanı (DT), Ejeksiyon zamanı (ET) ve pulmoner arter basıncı (PAB) değerleri dışındaki verilerde kadınlarla erkekler arasında ölçümlerde anlamlı fark görüldü (p0,01). Diyastolik disfonksiyon (DD) prevalansı %67,6 saptandı. Veriler cinsiyete göre değerlendirildiğinde, kadınlarla erkekler arasında ölçümlerde anlamlı fark görülmedi (p0,05). Çalışma popülasyonunun %3,2sinde asendan aorta anevrizması saptandı. Kalp yetmezliği oranı %1,7 bulundu. Örneklemin %0,8inde biküspid aort saptandı. Aort stenozu %3,4, aort yetmezliği %38,9, triküspid yetmezliği %52,8, pulmoner yetmezlik %12,4 oranında saptandı. Sonuç: Taşınabilir ve ucuz bir yöntem olması nedeniyle, ekokardiyografinin günümüzde kardiyovasküler hastalıkları değerlendirmede kullanılma oranı artmıştır. Kardiyovasküler hastalıkların erken tanı ve tedavisi ile hastalıkların ilerlemesi engellenebileceği ve hastaların yaşam kalitesinin artırılabileceği göz ardı edilmemelidir. Bu konuda daha fazla bilgi sahibi olmak için gelecekte yapılacak epidemiyolojik çalışmalara ihtiyaç duyulmaktadır.
