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    Malignant Epithelial Tumor in a Patient with Recurrent Axillary Abscess
    (2020) Çetin, Durmuş Ali; Kara, Özlem; Gümüş, Tufan; Patmano, Mehmet
    Skin infections are among the common diseases encountered in general surgery, dermatologyand pediatrics outpatient clinics. Skin abscess occurs as a result of pus accumulation in thedermis or subcutaneous tissue; it is composed of swollen, red, tender, fluctuating mass andoften accompanied by cellulite around them. The treatment is primarily antibiotic therapyaccording to the abscesses culture result after drainage with local anesthesia. Some of diseasessuch as diabetes, immunosuppressive conditions and cancer should be considered in adults,especially in recurrent abscesses. Skin metastasis in primary malignancies is very rare. Lungcancer is the most common one with skin metastasis. In this case report, we wanted toemphasize that the skin metastasis of primary malignancy should be kept in mind in cases withrecurrent abscess which is resistant to treatment.Keywords: Abscess; tumor; skin metastasis.
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    Protective effect of resveratrol on cisplatin induced damage in rat kidney
    (Cukurova Univ, Fac Medicine, 2022) Kara, Özlem; Kilitci, Asuman; Dağlıoğlu, Gülçin
    Purpose: The aim of this study was to evaluate the protective effect of resveratrol on cisplatin induced damage in rat kidney. Materials and Methods: 30 female Wistar-Albino rats were allocated to form three groups: In group 1 (control group), 1 mL of 0.9% NaCl (saline) was administered intraperitoneally for 3 days. In group 2 (cisplatin group), 7.5 mg / kg intraperitoneal cisplatin was given for 3 days. In group 3 (cisplatin + resveratrol group) 7.5 mg / kg cisplatin and 10 mg / kg resveratrol were given via intraperitoneal route. Right kidneys were surgically extirpated in all groups. Malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured in both blood and tissues. Also, toxicity markers such as vascular congestion, hemorrhage, tubule degeneration and glomerular damage were assessed by examining the slides prepared from kidney tissue with microscopy. Results: Tissue damage was significantly higher in group 2 than other groups. The MDA levels were significantly higher and the activities of SOD, and CAT were lower in group 2 than other groups. Conclusion: According to our short term findings, resveratrol might be an effective molecule to prevent the harmful effect of cisplatin in rat kidney.
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    The Protective Effect of Resveratrol on Cisplatin Induced Damage in Rat Liver
    (Galenos Publ House, 2022) Kara, Özlem; Kilitci, Asuman
    Aim: One of the underlying causes of cisplatin-induced hepatotoxicity is oxidative stress. We assessed the effect of an antioxidant, resveratrol, on cisplatin-induced damage in the rat liver. Methods: The project-starting date was designed as 01.10.2020 and the project-ending date was planned as 01.04.2021. Three groups were created with 30 female Wistar-Albino rats: In group 1 (control group), 1 mL of 0.9% NaCl (saline) was administered intraperitoneally for 3 days. In group 2 (cisplatin group), 7.5 mg/kg intraperitoneal cisplatin was given for 3 days. In group 3 (cisplatin + resveratrol group), 7.5 mg/kg cisplatin and 10 mg/kg resveratrol were given via the intraperitoneal route. The livers were surgically extirpated in all the groups. In both blood and tissues, malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured. Also, toxicity markers such as hepatocyte damage (cellular changes), inflammation, hemorrhage, congestion, fibrosis, disorganization of the hepatic cords, and necrosis were assessed by examining the preparations prepared from hepatic tissue with light microscopy and immunohistochemistry. Results: Histopathological tissue damage was significantly higher in group 2 than in other groups (p 0.03). MDA levels were significantly higher and the activities of SOD and CAT were lower in group 2 than in the other groups (p=0.04 and p=0.01, respectively). Conclusion: According to our short-term findings, resveratrol might be an effective molecule for preventing the harmful effects of cisplatin in the rat liver.
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    R. G. Collingwood’un Din Felsefesi
    (Düzce Üniversitesi, 2018) Kara, Özlem
    RobinGeorge Collingwood, 1889-1943 yılları arasında yaşamış, tarih felsefesialanında yaptığı çalışmalarla ünlü İngiliz filozofudur. Talip Kabadayı’nınderlediği bu eser; Collingwood’un, din ve din felsefesine dair bilinmeyengörüşlerini ortaya koyan makaleleri bir araya getirmesi açısından önem arzetmektedir. Eser, giriş bölümü ve Collingwood’un belirtilen konulara ilişkin 11adet makalesinin çevirilerinden oluşmaktadır.