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    Evaluation of in vivo DNA damaging and oxidative stress effects of sertraline
    (Elsevier Ireland Ltd, 2013) Aktas, Ayca; Battal, Dilek; Sungur, Mehmet Ali; Yalin, Serap; Kadioglu, Ela; Eker, Ebru Derici; Saygi, Sahan; Aktaş, Ayça; Battal, Dilek; Sungur, Mehmet Ali; Yalın, Serap; Kadıoğlu, Ela; Eker, Ebru Derici; Saygı, Şahan
    Sertraline, SSRI group of medicine, is the most frequently prescribed drug and well-known fact that central nervous system medication. In this study, the potential influence of the therapies with the different doses of sertraline on DNA damaging, lipid peroxidation levels and antioxidant enzyme activities were investigated. For this purpose Male Wistar Albino rats were divided into four group: control (n = 6), low (10 mg/kg/day), moderate (40 mg/kg/day), and high dose (80 mg/kg/day). Each treatment group had 6 animals and sertraline were administered by gavage throughout 28 days of the study. The alkaline comet assay and the cytokinesis-block micronucleus (CBMN) assay were used to evaluate DNA damaging potential of sertraline in the peripheral blood lymphocytes (PBLs). There is no statistically significant difference between sertraline treated groups and the negative control group with respect to comet assay results (p > .05). According to the data obtained from the CBMN test, an increase in the micronucleus (MN) frequency was detected only at high dose sertraline treatment. Serum paroxanase (PON), catalase (CAT), and superoxyde dismutase (SOD) activities were determined as well as malondialdehyde (MDA) lipid peroxidation for evaluation of oxidative stress effects of sertraline treatment. Serum SOD activities showed increase, CAT and PON activities decreased in all groups. Lipid peroxidation levels (MDA) increased in all sertraline treated rats (p < 0.05). Based on the data, it can be concluded that high dose sertraline administration enhances oxidative stress. Therefore, dose adjustment in depression patients seems significant as it may help prevention of further prognosis of the diseases.