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    Foreign Body Aspiration in Children; Duzce University Five-Years Results
    (Duzce Univ, Fac Medicine, 2021) Sav, Nadide Melike; Kilicaslan, Onder; Karaca, Seda Erisen; Tamturk, Cansu; Kabaklioglu, Murat
    Objective: Foreign body aspiration is a preventable cause of mortality and morbidity especially in younger than three years old children. The aim of this study is to determine the risk factors, causes and prognosis in patients with foreign body aspiration. Methods: In this study, laboratory and examination findings of 35 patients who underwent bronchoscopy, because of suspected foreign body aspiration, were retrospectively analyzed. Results: Of the 35 patients included in the study, 19 were boys and 16 were girls. The mean age was 3,2. The most causes of application were cough, and wheezing. Foreign body was detected in the right main bronchus in 62,8%, in the left main bronchus in 25,7%, in the trachea in 5,7% and in both bronchi in 5,7% of the patients. Conclusions: Early diagnosis and intervention significantly reduce the mortality and morbidity in foreign body aspirations. Prevention of foreign body aspirations is possible with the education of babysitters and family members.
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    Short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes
    (Springer, 2021) Kabaklioglu, Murat; Kaya, Murat; Sahin, Ibrahim Ethem; Gamsizkan, Mehmet; Bahcivan, Atike; Eroz, Recep
    Rapamycin has antioxidant defense mechanisms and immune suppressive effects. To detect the short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes, mature male albino Wistar rats (n = 48) were included in the study as control, sham, early torsion-detorsion (T/D), early rapamycin treatment, early rapamycin control, late T/D, late rapamycin treatment, and late rapamycin control. The right testis was rotated 720 degrees in a clockwise direction during 4 h in operation groups. Rapamycin was administered orally three times: 30 min before detorsion and 24 and 48 h after detorsion. The animals were killed on the third day in early groups and on the tenth day in late groups after detorsion. Statistically significant differences among all groups were detected for SOD and TBARS, mean seminiferous tubule diameter (MSTD) and Cosentino's histologic score (CHS), caspase 3, bax, average number of apoptotic cells per tubule (ANPCT), and percentage of apoptotic tubule (PAT) values. ANPCT values were 10% lower in the rapamycin treatment groups compared with the untreated T/D groups, and the PAT values were also approximately 1.3 times lower. Although short-term usage of rapamycin may reduce to the tubular injury caused by I/R conversely to apoptosis in the testicular tissue after testicular torsion, rapamycin may have the potential to increase the long-term apoptosis with/without testicular torsion and a subsequent regression in fertility.