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Öğe Nanoconjugate formulations for enhanced drug delivery(Elsevier, 2023) Oner, E.; Ilhan, M.; Gultekin, H.E.; Karpuz, M.Nanoconjugate is the nanosized drug delivery system, which consists of a drug molecule or a drug-loaded carrier attached to a moiety covalently or noncovalently. There is a growing interest in these versatile nanoconjugates due to their suitability to design with moieties improving the efficacy and safety of drugs by targeting the desired location in the body, increasing solubility or stability, and controlling the release conditions. Today, many nanoconjugate formulations have entered the market to diagnose and treat several diseases, especially cancer. Antibody-drug conjugate pipeline has been widened with cutting-edge manufacturing technologies. Carbohydrate-conjugated therapeutic nucleic acid elements of RNA interference and antisense technologies open a new era to treat liver-associated diseases. Also, nanoconjugate formulations formed with other moieties, such as polymers, peptides, oligonucleotides, gold nanoparticles, and lipids, show promising results to be used in the clinic. This chapter summarizes the strategies used in these nanoconjugate systems to enhance drug delivery. Besides, a comprehensive review of the main types of drug conjugates (including polymer-, peptide-, antibody-, nucleic acid-, carbohydrate-, lipid-drug conjugates) used for conventional therapy, nucleic acid therapy, imaging, diagnosis, and theranostic applications is presented together with the latest preclinical studies, clinical trials, and approvals. © 2023 Elsevier Inc. All rights reserved.Öğe Novel Drug Targets With Traditional Herbal Medicines: Scientific and Clinical Evidence(Springer International Publishing, 2022) Gürağaç, Dereli, F.T.; Ilhan, M.; Belwal, T.This book collects information about the most popular ethnomedicinal plants, which are common in Turkey and around the world. It presents the ethnopharmacological records, in vivo and in vitro studies, side effects, chemical compositions and clinical studies of these medicinal plants. Its special focus is on the novel drug targets for disease and their possible mechanisms of action. It covers botanical descriptions the status of the plants, and food or drug interactions including precautions and warnings about the plants and the available market products. It provides an explanation of recorded and known plant administration dosages. Also, the gap between the traditional practice and scientific/clinical evidences in the use of ethnomedicinal plant is acknowledged. It is well known that traditional knowledge of the use of the medicinal plants in therapy is an important resource for the discovery of novel treatment options and drug targets. The main purpose of this book is to draw attention to ethnomedicinal plant species. Data on the therapeutic potentials of these medicinal plants can now be accessed from a single source. It provides an important resource for future research opportunities for harnessing the full potential of these plants. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.Öğe Preface(Springer International Publishing, 2022) Gürağaç, Dereli, F.T.; Ilhan, M.; Belwal, T.[No abstract available]
