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    A comparison of personality characteristics between patients with cancer and the control group
    (Duzce University Medical School, 2019) Özçetin, Adnan; Kılıç, Osman; Ataoğlu, Ahmet; Ölmez, Safiye Bahar; Hisarvant, Arzu
    Aim: It is known that personality can affect most of the issues related to physical and mental health. It is thought that some personality features carry importance as a factor in cancer development, and therefore, the theory of a cancer-prone personality continues to attract researchers’ attention. The aim of this study is to investigate and compare the differences in personality characteristics between patients with different types of cancer and healthy control group. Material and Methods: A total of 193 participants, patients with different types of cancer (n=100) and healthy individuals as the control group (n=93), were included in this study. Hacettepe Personality Inventory (HPI) was used to obtain the data related with personality traits. Results: The mean score of self-realization (SR) and emotional stability (ES), which are personal adaptation subscales of the HPI, was found to be significantly lower in cancer group compared to control group (p=0.016 and p=0.009). As a result of further analyses performed according to cancer types, it was found that both SR and ES scores in head-neck cancer group were lower than both control group and other subgroups of cancer types (p=0.004 and p=0.001). Conclusion: The results of this study revealed that there are differences between cancer and control groups in terms of personality characteristics. Overall, it was thought that the personality characteristics that are unique to patients with head-neck cancers may be the reactions that appear as a result of the development of head-neck cancer rather than a significant factor in cancer development. © 2019, Duzce University Medical School. All rights reserved.
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    A comparison of plasma nitrite, nitrate and asymmetric dimethylarginine levels in major depression patients before and after escitalopram treatment
    (Nobelmedicus, 2018) Hisarvant, Arzu; Ataoğlu, Ahmet; Özçetin, Adnan; Kılıç, Osman; Ölmez, Safiye Bahar; Kuduban, Ali Kemal
    Objective: Asymmetric dimethyl arginine (ADMA) function, which is an intracellular repressor of nitric oxide (NO) and NO, examined and revealed in many mental disorders. In this study, we compared the simultaneous levels of plasma nitrite (NO2), nitrate (NO3) and ADMA before and after escitalopram treatment at Major Depression Disorder (MDD) patients and healthy controls. Material and Method: 40 patients with MDD according to DSM-IV-R and 40 heathy controls was included in this study. The Montgomery-Åsberg Depression Rating Scale was used to determine the severity of illness. Plasma NO2, NO3 and ADMA levels were measured in the MDD and the control groups. Results: Pretreatment plasma NO2, NO3 and ADMA levels in MDD group were significantly lower (but ADMA levels were higher) than in the control group. After the treatment NO levels of MDD group were close to control group, ADMA levels were statistically lower than the control group. Conclusion: Our study can contribute to the understanding of the role of NO and ADMA and relationship between complicated neurotransmitter systems at MDD etiopathogenesis. © 2018, Nobelmedicus. All rights reserved.
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    A COMPARISON OF PLASMA NITRITE, NTTRATE AND ASYMMETRIC DIMETHYL ARGININE LEVELS MAJOR DEPRESSION PATIENTS BEFORE AND AFTER ESCITALOPRAM TREATMENT
    (Nobel Ilac, 2018) Hisarvant, Arzu; Ataoğlu, Ahmet; Özçetin, Adnan; Kılıç, Osman; Ölmez, Safiye Bahar; Kuduban, Ali Kemal
    Objective: Asymmetric dimethyl arginine (ADMA) f unction, which is an intracellular repressor of nitric oxide (NO) and NO, examined and revealed in many mental disorders. In this study, we compared the simultaneous levels of plasma nitrite (NO), nitrate (NO3) and ADMA before and after escitalopram treatment at Major Depression Disorder (MDD) patients and healthy controls. Material and Method: 40 patients with MDD according to DSM-IV-IR and 40 heathy controls was included in this study. The Montgomery-Asberg Depression Rating Scale was used to determine the severity of illness. Plasma NO2, NO3 and ADMA levels were measured in the MDD and the control groups. Results: Pretreatment plasma NO2, NO3 and ADMA levels in MDD group were significantly lower (but ADMA levels were higher) than in the control group. After the treatment NO levels of MDD group were close to control group. ADMA levels were statistically lower than the control group. Conclusion: Our study can contribute to the understanding of the role of NO and ADMA and relationship between complicated neurotransmitter systems at MDD etiopathogenesis.