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    Gender Classification Using Parameters Obtained from the Dens Axis with Machine Learning Algorithms and Multilayer Perceptron Classifier
    (Dubai Iranian Hosp, 2025) Harmandaoglu, Oguzhan; Secgin, Yusuf; Kaya, Seren; Ozturk, Oguzhan; Senol, Deniz; Onbas, Omer
    Background and Objectives: Due to the difficulties associated with the separation, damage, cremation, and commingling of skeletal remains, it is of great importance in forensic medicine to assess the accuracy and reliability of sex estimates derived from different skeletal components. For this purpose, this study aimed to classify gender using machine learning (ML) algorithms and a multilayer perceptron classifier (MLPC) based on morphometric data of the dens axis obtained from computed tomography (CT) images. Methods: Retrospectively, measurements were taken from CT images of 300 male and 300 female individuals aged between 18-65 years, including dens axis height (DAH), anteroposterior (APDDA) and anterosuperior lengths (ASDDA), dens axis angle (DAA), clivodental angle (CDA), and Boogard angle (BOO). Machine learning models such as Extra Tree Classifier (ETC), Random Forest (RF), Decision Tree (DT), Gaussian Naive Bayes (GaussianNB), k-Nearest Neighbors (k-NN), Linear Discriminant Analysis (LDA), Quadratic Discriminant Analysis (QDA), and Logistic Regression (LR) were used. MLPC was chosen as artificial neural networks (ANN) model. Results: Significant differences were found between genders in all dens axis parameters except BOO (p<0.05). The highest accuracy rate in ML algorithm modeling was found to be 0.80 with LDA, RF, k-NN algorithms, and MLPC. The parameter with the highest impact on gender classification was the dens axis anterosuperior length. Conclusion: It was found that the parameters obtained from the dens axis using MLCP and ML algorithms have sufficient accuracy rates the classification of sex. It was concluded that in forensic medicine, in cases of deterioration, loss, and deficiencies in bone sources for biological identity determination, the morphometric features of the dens axis can be considered for gender prediction.
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    Gender Prediction Using Cone-Beam Computed Tomography Measurements from Foramen Incisivum: Application of Machine Learning Algorithms and Artificial Neural Networks
    (Wolters Kluwer Medknow Publications, 2024) Senol, Deniz; Secgin, Yusuf; Harmandaoglu, Oguzhan; Kaya, Seren; Duman, Suayip Burak; Oner, Zuelal
    Introduction: This study aims to predict gender using parameters obtained from images of the foramen (for.) incisivum through cone-beam computed tomography (CBCT) and employing machine learning (ML) algorithms and artificial neural networks (ANN).Materials and Methods: This study was conducted on 162 individuals in total. Precise measurements were meticulously extracted, extending from the foramen incisivum to the arcus alveolaris maxillaris, through employment of CBCT. The ML and ANN models were meticulously devised, allocating 20% for rigorous testing and 80% for comprehensive training.Results: All parameters that are evaluated, except for the angle between foramen palatinum majus and foramen incisivum-spina nasalis posterior (GPFIFPNS-A), exhibited a significant gender difference. ANN and among the ML algorithms, logistic regression (LR), linear discriminant analysis (LDA), and random rorest (RF) demonstrated the highest accuracy (Acc) rate of 0.82. The Acc rates for other algorithms ranged from 0.76 to 0.79. In the models with the highest Acc rates, 14 out of 17 male individuals and 13 out of 16 female individuals in the test set were correctly predicted.Conclusion: LR, LDA, RF, and ANN yielded high gender prediction rates for the measured parameters, while decision tree, extra tree classifier, Gaussian Naive Bayes, quadratic discriminant analysis, and K-nearest neighbors algorithm methods provided lower predictions. We believe that the evaluation of measurements extending from foramen incisivum to arcus alveolaris maxillaris through CBCT scanning proves to be a valuable method in gender prediction.
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    Sex estimation based on frontal sinus computed tomography images using machine learning and artificial neural networks
    (Taylor & Francis Ltd, 2025) Kaya, Seren; Harmandaoglu, Oguzhan; Ozturk, Oguzhan; Secgin, Yusuf; Senol, Deniz; Onbas, Omer
    Due to its anatomical uniqueness, the frontal sinus (FS) shows significant inter-individual differences by ancestry, age, and sex, making it useful for preliminary identification processes. This study aims to estimate sex using machine learning (ML) algorithms and artificial neural networks (ANN) applied to morphometric data from FS computed tomography (CT) images. This retrospective study analysed CT scans of 338 females and 338 males aged 18-65. FS measurements comprised sinus floor anteroposterior length, volume, area, height, depth, width, and anterior wall thickness (AWT). Sex estimation was performed using several ML algorithms, including Linear Discriminant Analysis, Quadratic Discriminant Analysis, Logistic Regression, Extra Trees Classifier, Decision Tree, Random Forest, k-Nearest Neighbours, and Gaussian Naive Bayes. Additionally, a multilayer perceptron classifier, representing ANN models, was utilized. The highest classification accuracy (94%) was achieved by the Logistic Regression model. According to the SHapley Additive exPlanations analysis, the two most influential parameters were identified as the right and left AWT, respectively. This study, with a comparatively large sample size, found that all morphometric FS parameters - especially AWT - hold significant potential in forensic identification. ML- and ANN-based models showed high classification accuracy, surpassing previous studies. These findings may guide future research involving diverse populations and regions.
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    Sex estimation with parameters of the facial canal by computed tomography using machine learning algorithms and artificial neural networks
    (Bmc, 2025) Secgin, Yusuf; Kaya, Seren; Harmandaoglu, Oguzhan; Ozturk, Oguzhan; Senol, Deniz; Onbas, Omer; Yilmaz, Nihat
    BackgroundThe skull is highly durable and plays a significant role in sex determination as one of the most dimorphic bones. The facial canal (FC), a clinically significant canal within the temporal bone, houses the facial nerve. This study aims to estimate sex using morphometric measurements from the FC through machine learning (ML) and artificial neural networks (ANNs).Materials and methodsThe study utilized Computed Tomography (CT) images of 200 individuals (100 females, 100 males) aged 19-65 years. These images were retrospectively retrieved from the Picture Archiving and Communication Systems (PACS) at D & uuml;zce University Faculty of Medicine, Department of Radiology, covering 2021-2024. Bilateral measurements of nine temporal bone parameters were performed in axial, coronal, and sagittal planes. ML algorithms including Quadratic Discriminant Analysis (QDA), Linear Discriminant Analysis (LDA), Decision Tree (DT), Extra Tree Classifier (ETC), Random Forest (RF), Logistic Regression (LR), Gaussian Naive Bayes (GaussianNB), and k-Nearest Neighbors (k-NN) were used, alongside a multilayer perceptron classifier (MLPC) from ANN algorithms.ResultsExcept for QDA (Acc 0.93), all algorithms achieved an accuracy rate of 0.97. SHapley Additive exPlanations (SHAP) analysis revealed the five most impactful parameters: right SGAs, left SGAs, right TSWs, left TSWs and, the inner mouth width of the left FN, respectively.ConclusionsFN-centered morphometric measurements show high accuracy in sex determination and may aid in understanding FN positioning across sexes and populations. These findings may support rapid and reliable sex estimation in forensic investigations-especially in cases with fragmented craniofacial remains-and provide auxiliary diagnostic data for preoperative planning in otologic and skull base surgeries. They are thus relevant for surgeons, anthropologists, and forensic experts.Clinical trial numberNot applicable.