Yazar "Habiloglu, Arif Dogan" seçeneğine göre listele

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    The Efficacy of Glecaprevir/Pibrentasvir in Chronic Hepatitis C Patients and the Impact of the COVID-19 Pandemic: Multicenter Real-Life Data
    (Doc Design Informatics Co Ltd, 2024) Gurbuz, Yunus; Kocagul-Celikbas, Aysel; Oztoprak, Nefise; Aygen, Bilgehan; Batirel, Ayse; Habiloglu, Arif Dogan; Aktug-Demir, Nazlim
    Objective: This study aimed to demonstrate the real-life efficacy and safety of glecaprevir / pibrentasvir in the treatment of chronic hepatitis C, as well as to identify the problems caused by the COVID-19 pandemic in the follow-up and treatment of patients. Materials and Methods: The study was conducted retrospectively with the participation of researchers from universities or training and research hospitals. It included patients with chronic hepatitis C who were over 18 years of age, treatment-na & iuml;ve or treatment-experienced, had detectable HCV RNA and were receiving glecaprevir/pibrentasvir treatment Results: Only 188 of the 385 patients who participated in the study came to the follow-up visit 12 weeks after treatment, and all of them had a sustained virological response. It was thought that a significant portion of the 177 patients who did not come to the follow-up visit at 12 weeks after treatment refrained from coming to the hospital due to the COVID-19 pandemic. None of the patients who attended the follow-up visits required treatment discontinuation due to adverse events. Conclusion: Glecaprevir/pibrentasvir is a highly effective and relatively safe drug in the treatment of chronic hepatitis C. The COVID-19 pandemic has negatively affected the follow-up and treatment processes of patients. New measures are needed for the follow-up and treatment of patients with chronic hepatitis C during pandemics.
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    Evaluation of Nasal Mucociliary Clearance in Recently Diagnosed Covid-19 Patients Before Treatment
    (Duzce Univ, Fac Medicine, 2023) Koder, Ahmet; Kilicaslan, Saffet; Belada, Abdullah; Habiloglu, Arif Dogan; Ataoglu, Ozlem; Sungur, Mehmet Ali; Atik, Dursun
    Objective: Our study aims to evaluate the nasal mucociliary clearance (NMC) in Covid-19 patients who have been recently diagnosed and not been treated yet and investigate how Covid-19 affects NMC.Methods: A total of 120 participants, who applied to Duzce Ataturk State Hospital between September and November 2020, were included in our study. 60 of them were the participants, diagnosed with Covid-19. And 60 of them were the control group. The age range was 18 to 66. 60 participants, diagnosed with Covid-19 and not yet treated, were included in our study. Those with taste disorders were excluded from the study. The control group consisted of 60 healthy volunteers. NMC was evaluated using a saccharin test. The results were compared in the Statistical Package for Social Sciences (SPSS).Results: The study group, which consisted of 60 Covid-19 participants of whom treatment was not yet started, and the 60-participant healthy control group were evaluated in our study. The average age of the study group was 40,72 +/- 12,96 and 39,16 in the control group. The average NMC was 15,95 +/- 3,37 in the study group, and 8,38 +/- 1,03 in the control group. When evaluated statistically, it was found higher in the study group (p<0,001).Conclusions: NMC acts as a barrier for inhaled foreign bodies. It is a non-specific protection system against airborne pathogens. Consequently, NMC extends in Covid-19 patients.
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    Identification of Sars-Cov-2 related volatile organic compounds from face masks
    (Elsevier, 2024) Canbay, Hale Secilmis; Kismali, Gorkem; Emen, Fatih Mehmet; Habiloglu, Arif Dogan; Sareyyupoglu, Baris; Akcay, Aytac; Ozturk, Hakan
    This study aims to identify SARS-CoV-2-related volatile organic compounds (VOCs) of the exhaled breath from face masks. Face masks collected from SARS-CoV-2 patients (n = 30) and the control group (n = 11) were analyzed to detect VOCs in the exhaled breath using the Headspace-Gas Chromatography Mass Spectrometry. Significant increases in concentrations of toluene, hexadecane, and phenol were detected in the face masks belonging to patient groups (p < 0.001). Clinical sig-nificance was further found in isobutyric acid levels considering Cohen's d value (p = 0.070). The findings of this study suggest that monitoring toluene, hexadecane, phenol, and isobutyric acid could provide considerable support in rapid screening of SARS-CoV-2.