Yazar "Gunes, Harun" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim
    Öğe
    Can serum NSE and S100-beta protein levels predict central nervous system injury in patients with carbon dioxide retention?
    (Kuwait Medical Assoc, 2020) Gunes, Harun; Candar, Muhammed M.; Saritas, Ayhan
    Objectives: To evaluate whether serum neuron specific enolase (NSE) or S100-beta protein levels are helpful in predicting central nervous system (CNS) injury in patients with carbon dioxide (CO2) retention Design: A case-control study Setting: This study was performed in the Emergency Department of a University Hospital which functions as the only tertiary center in the city. Subjects: One hundred patients who were admitted to the emergency department and seen to have an arterial partial carbon dioxide pressure above 45 mmHg were included as the study group and 48 healthy volunteers as the control group. Interventions: None Main outcome measures: Possible elevations in serum NSE and/or S100-beta protein levels in the study group were main outcome measures. The levels of these markers were measured using enzyme-linked immunoassay kits, and mean values of these parameters were compared between the study and the control groups. Results: Mean NSE level was found to be 69.45 +/- 36.39 ng/ml, and mean S100-beta level was 160.57 +/- 54.05 pg/ml in the study group. Mean NSE and S100-beta levels of the control group were 30.99 +/- 20.04 ng/ml and 129.31 +/- 415.17 pg/ml, respectively. Mean NSE levels differed significantly between the study and control groups; however, mean S100-beta levels did not. Conclusions: The results of the present study suggest that NSE can be used to predict CNS injury in patients with CO2 retention, but S100-beta protein cannot. New studies including larger number of patients are needed to obtain more accurate results on this topic.
  • Küçük Resim Yok
    Öğe
    Characteristics and outcomes of patients with chronic obstructive pulmonary disease admitted to the intensive care unit due to acute hypercapnic respiratory failure
    (Korean Soc Critical Care Medicine, 2023) Akbas, Turkay; Gunes, Harun
    Background: The study aimed to describe the clinical course, outcomes, and prognostic factors of chronic obstructive pulmonary disease (COPD) patients with acute hypercapnic respiratory failure. Methods: This retrospective study involved patients with acute hypercapnic respiratory failure due to COPD of any cause admitted to the intensive care unit (ICU) for non-invasive or invasive mechanical ventilation (IMV) support between December 2015 and February 2020. Results: One hundred patients were evaluated. The main causes of acute hypercapnic respiratory failure were bronchitis, pneumonia, and heart failure. The patients' mean Acute Physiology and Chronic Health Evaluation (APACHE) II score was 23.0 +/- 7.2, and their IMV rate was 43%. ICU, in-hospital, and 90-day mortality rates were 21%, 29%, and 39%, respectively. Non-survivors had more pneumonia, shock within the first 24 hours of admission, IMV, vasopressor use, and renal replacement therapy, along with higher APACHE II scores, lower admission albumin levels and PaO2/FiO(2) ratios, and longer ICU and hospital stays than survivors. Logistic regression analysis identified APACHE II score (odds ratio [OR], 1.157; 95% confidence interval [CI], 1.017-1.317; P=0.026), admission PaO2/FiO(2) ratio (OR, 0.989; 95% CI, 0.978-0.999; P=0.046), and vasopressor use (OR, 8.827; 95% CI, 1.650-47.215; P=0.011) as predictors of ICU mortality. APACHE II score (OR, 1.099; 95% CI, 1.021-1.182; P=0.011) and admission albumin level (OR, 0.169; 95% CI, 0.056-0.514; P=0.002) emerged as predictors of 90-day mortality. Conclusions: APACHE II scores, the PaO2/FiO(2) ratio, vasopressor use, and albumin levels are significant short-term mortality predictors in severely ill COPD patients with acute hypercapnic respiratory failure.
  • Küçük Resim Yok
    Öğe
    Lower Free T3 Levels Linked to Poorer Outcomes in Chronic Obstructive Pulmonary Disease Patients with Acute Hypercapnic Respiratory Failure
    (Sciendo, 2024) Akbas, Tuerkay; Gunes, Harun
    Aim of the Study Non-thyroidal illness syndrome (NTIS) is often observed in critically ill patients. This study aimed to examine thyroid hormone changes in patients with chronic obstructive pulmonary disease (COPD) experiencing acute hypercapnic respiratory failure (AHRF) and to evaluate the impact of these alterations on clinical outcomes.Materials and Methods This retrospective investigation involved 80 COPD patients (age 71.5 +/- 9.5 years; 57.5% male) admitted to the intensive care unit (ICU) due to AHRF. NTIS was identified when free triiodothyronine (fT3) levels were below the lower limit, and thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels were within the normal range or below the lower limits.Results NTIS was detected in 63.7% of the patients. Decreased fT3 levels were found in 36.3% of the patients, reduced T4 levels in 33.8%, and diminished TSH levels in 15%. Patients with low fT3 levels exhibited elevated C-reactive protein levels, white blood cell counts, and APACHE II scores, necessitated vasopressor infusion more frequently during their ICU stay, and had increased mortality. The in-hospital mortality rate was 28.8%. Logistic regression analysis revealed that fT3 level (odds ratio [OR]., 0.271; 95% confidence interval [CI]., 0.085-0.865; p=0.027), APACHE II score (OR, 1.155; 95% CI, 1.041-1.282; p=0.007), and vasopressor use (OR, 5.426; 95% CI, 1.439-20.468; p=0.013) were crucial predictors of in-hospital mortality.Conclusions A high prevalence of NTIS is observed in COPD patients with AHRF, with low fT3 levels frequently observed. The presence of lower levels of fT3 is associated with a greater severity of the disease and a significant prognostic indicator.
  • Küçük Resim
    Öğe
    Use of argyrophilic nucleolar-organizer region-associated protein synthesis in skeletal muscle cells for prediction of chronic carbon monoxide exposure
    (Taylor & Francis Inc, 2020) Gunes, Harun; Saritas, Ayhan; Eroz, Recep; Colakoglu, Serdar
    This study aims to evaluate possible effects of chronic carbon monoxide (CO) exposure on argyrophilic nucleolar-organizer region (AgNOR)-associated protein synthesis in striated muscle cells. Eighteen rats were randomly divided into three groups. Rats in group II and group III were given CO gas (1000 and 3000 ppm, respectively) for 30 min a day for 7 d. Mean AgNOR number per nucleus and ratio of total AgNOR area to nuclear area (TAA/NA) were determined. Both TAA/NA ratio and mean AgNOR number provided information about the existence or absence of exposure. TAA/NA ratio was also an indicator of the level of exposure.