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    The Effect Of L-Carnitine And Alpha Lipoic Acid Administration With Exercise In Old Rats On Energy Metabolism Related To Oxidative Stress Parameters
    (Marmara Univ, Inst Health Sciences, 2024) Kalkan, Kardelen Kocaman; Sirin, Neslihan; Tepe, Atakan; Gok, Ali; Altas, Tolga; Agan, Kagan; Gulhan, Pinar Yildiz
    Objective: This study aims to contribute novel insights by investigating the potential positive effects of a combined dietary supplement and exercise program on mitochondrial oxidative stress and energy metabolism in aging. Focusing on the protective impact of Alpha Lipoic Acid (ALA), a potent antioxidant, against exercise-induced mitochondrial oxidative stress in rats, we also assess how L-Carnitine administration affects exercise ability by analyzing resistin and HbA1c levels, indicators linked to insulin resistance and cellular sensitivity. Method: In this 10-day study, 42 old male Sprague Dawley rats (weighing 400 +/- 10 g, aged 15-17 weeks) were divided into six groups (n=7): Control, Exercise, L-Carnitine, Alpha Lipoic Acid (ALA), L-Carnitine+Exercise, ALA+Exercise. Relevant groups received daily oral gavage doses of L - Carnitine (50 mg/ml) and ALA (18 mg/ml). Exercise groups underwent treadmill sessions. On day 10, blood samples were quantitatively analyzed for HbA1c and Resistin levels using a Cusabio ELISA assay kit (China). Results: ALA supplementation synergistically reduced resistin and HbA1c levels, individually and combined with exercise. Conversely, L-Carnitine supplement, alone or with exercise, increased resistin levels but it caused a decrease in HbA1c levels. Conclusion: The data indicated a minor, insignificant decrease in resistin levels for the exercise and ALA groups, with a statistically significant difference in HbA1c levels among all groups. Exercise alone positively impacted both HbA1c and resistin levels, suggesting a potential counteraction of age-related oxidative stress and a positive influence on energy metabolism through an appropriate diet and exercise program. Further studies are required to explore specific metabolic pathways and relationships identified in our findings.
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    Efficacy of Sinapic Acid Administration in a Model of PenicillinInduced Epilepsy
    (Wiley, 2023) Coskun, Ayca; Beyazcicek, Ersin; Beyazcicek, Ozge; Gok, Ali
    [No abstract available]
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    Investigation of The Effects of Fatty Acids on Growth Hormone, Insulin-like Growth Factor 1, and Insulin- and Hormone-sensitive Lipase Levels in Rats
    (Galenos Publ House, 2024) Emir, Aysegul; Beyazcicek, Ozge; Beyazcicek, Ersin; Gok, Ali
    Objective: Several studies have investigated hormones such as growth hormone (GH), insulin (INS), insulin-like growth factor-1 (IGF-1), and hormone- sensitive lipase (HSL). However, there is insufficient data on the effects of the combination of short-, medium-, and long-chain fatty acids on hormone concentrations in serum/tissue, including GH, INS, IGF-1, and HSL. The purpose of this study was to investigate the effects of butyric acid (BA), caprylic acid (CA), and oleic acid (OA) alone or in combination on GH, INS, IGF-1, and HSL secretion. Methods: Fifty-six male Wistar rats were used in the study. The animals were separated into 8 subgroups: control, BA, CA, OA, BA + CA, BA + OA, CA + OA, and BA + CA + OA groups. Fatty acids were administered orally to rats for 21 days. At the end of the study, GH, IGF, INS, and HSL levels were measured in serum using the enzyme-linked immunosorbent assay method. Results: BA administration reduced GH, IGF-1, and INS levels but had no significant effect on HSL levels. CA administration increased HSL levels but had no significant effect on GH, INS, and IGF-1 levels. OA administration increased GH and HSL levels but had no significant effect on IGF-1 and INS levels. Conclusion: The combined use of fatty acids increased GH levels while decreasing INS, IGF-1, and HSL levels.
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    Protective effects of lupeol on acute exercise-related oxidativestress in male rats
    (Marmara Univ, Fac Pharmacy, 2024) Ozdemir, Emrah; Coknaz, Hakki; Sener, Sila oezlem; Ozgen, Ufuk; Gok, Ali
    The aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats.Rats were randomly selected and divided into four groups (n=6/group): Control, exercise, lupeol and exercise+lupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione (GSH), coenzyme Q10 (CoQ10) and alpha-lipoic acid (ALA) and oxidative stress levels in serum samples were measured.As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed tooxidative stress inhibits free radicals formed by stress.In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damage