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    Effect of a 50-Hz Sinusoidal Electromagnetic Field on the Integrity of Experimental Colonic Anastomoses Covered with Fibrin Glue
    (Wroclaw Medical Univ, 2009) Girgin, Sadullah; Öztürk, Hayrettin; Gedik, Ercan; Akpolat, Veysi; Kale, Ebru; Öztürk, Hülya
    Background. Low-frequency magnetic fields have been shown to affect biological processes. In this article the effects of 50-Hz sinusoidal magnetic field (MF) stimulation and application of fibrin glue on the healing of experimental colonic anastomoses were investigated. Material and Methods. Twenty-eight rats were divided into four groups. Group 1 underwent 2-cm left colonic resection and primary anastomosis. Group 2 underwent normal resection anastomosis and the area was covered with fibrin glue. Group 3 underwent normal resection anastomosis and the rats were exposed to a 50-Hz sinusoidal MF. Group 4 underwent normal resection anastomosis, the anastomosis area was covered with fibrin glue, and the rats were exposed to a 50-Hz sinusoidal MF. Investigations included bursting pressure measurement, hydroxyproline content, and histopathological changes. Results. Tissue hydroxyproline levels and anastomotic bursting pressures of groups 2, 3, and 4 were significantly higher than in group 1. Collagen deposition and fibroblast infiltration in groups 2, 3, and 4 had higher scores than in group 1. Furthermore, these results were significantly higher in group 4 rats than in the other groups. Histopathological examination of the anastomosis revealed significantly better healing patterns for group 4 than for groups 1, 2, and 3. Conclusions. A50-Hz sinusoidal MF stimulation and application of fibrin glue provided a significant gain in anastomotic healing in the large intestine. A combination of a 50-Hz sinusoidal MF and fibrin glue has significantly favorable effects on healing of experimental colon anastomosis (Adv Clin Exp Med 2009, 18, 1, 13-18).
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    Iloprost, a prostacyclin (PGI2) analogue, reduces liver injury in hepatic ischemia-reperfusion in rats
    (2009) Gedik, Ercan; Girgin, Sadullah; Obay, Basra Deniz; Öztürk, Hayrettin; Öztürk, Hülya; Büyükbayram, Hüseyin
    Purpose: To evaluate the effects of iloprost a prostacyclin analogue on the hepatic IR injury in rats. Methods: Forty male Sprague-Dawley rats (250-300 g) were divided into four groups each containing 10 rats; - (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats that underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/ Iloprost group: rats pretreated with iloprost (10 ?g kg-1, i.v). Liver tissues were taken to determine SOD, CAT, GSH, and MDA levels and for biochemical and histological evaluation. Results: The plasma ALT and AST levels were increased in group 3 than in group 4. MDA values and the liver injury score decreased, while the SOD, CAT, and GSH values increased in group 4 compared to group 3. In group 3, hepatocytes were swollen with marked vacuolization. In group 4, there were regular sinusoidal structures with normal morphology without any signs of congestion. Conclusion: We demonstrated hepatoprotective effects of iloprost against severe ischemia and reperfusion injury in rat liver.
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    Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats
    (Baishideng Publishing Group Inc, 2008) Gedik, Ercan; Girgin, Sadullah; Öztürk, Hayrettin; Obay, Basra Deniz; Öztürk, Hülya; Büyükbayram, Hüseyin
    AIM: To investigate the effects of resveratrol on liver ischemia/reperfusion (I/R) injury in rats. METHODS: A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/Resveratrol group: rats pretreated with resveratrol (10 mu mol/L, iv). Liver tissues were obtained to determine antioxidant enzyme levels and for biochemical and histological evaluation. RESULTS: Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase, and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratrol-treated livers. CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusionrelated liver injury. (C) 2008 The WIG Press. All rights reserved.
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    Surveillance of Nosocomial Infections in General Surgery Unit: Data of Ten Years Period
    (Düzce Üniversitesi, 2010) Geyik, Mehmet Faruk; Aldemir, Mustafa; Tekin, Recep; Çelen, Mustafa Kemal; Girgin, Sadullah; Hosoğlu, Salih; Ayaz, Celal
    Aim: The aim of this study is to evaluate the epidemiologic data of nosocomial infection (NI)occurring in the General Surgery Unit (GSU).Method: This study was performed between January 1997 and December 2006. The surveillancemethod was active, prospective, and based on laboratory and patient. NIs were defined accordingto Centers for Diseases Control and Prevention criteria (CDC).Results: During the ten-year period, 305 NI episodes were detected in 290 patients. The overallincidence rates and incidence densities of NIs were 2.0% and 2.3/1,000 patient-day respectively.The most common NIs by primary site were surgical site infections, urinary tract infections,and pneumonia. The most prevalent microorganisms were Escherichia coli (36.8%),Staphylococcus aureus (17.7%) and Pseudomonas aeruginosa (10.5%). Meticillin resistanceamong S. aureus isolates was 76%. Meropenem and amikacin were the most effective agentsagainst to Gram-negative bacteria. Conclusion: In order to detect of the variation and trends of NIs, the data of surveillanceactivities must be evaluated decisively and regularly with collaboration among infection controlteam, Infectious Disease clinic, and GSU
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    Surveillance of nosocomial infections in general surgery unit: Data of ten years period
    (2010) Üstün, Cemal; Geyik, Mehmet Faruk; Aldemir, Mustafa; Tekin, Recep; Çelen, Mustafa Kemal; Girgin, Sadullah; Ayaz, Celal
    Aim: The aim of this study is to evaluate the epidemiologic data of nosocomial infection (NI) occurring in the General Surgery Unit (GSU). Method: This study was performed between January 1997 and December 2006. The surveillance method was active, prospective, and based on laboratory and patient. NIs were defined according to Centers for Diseases Control and Prevention criteria (CDC). Results: During the ten-year period, 305 NI episodes were detected in 290 patients. The overall incidence rates and incidence densities of NIs were 2.0% and 2.3/1,000 patient-day respectively. The most common NIs by primary site were surgical site infections, urinary tract infections, and pneumonia. The most prevalent microorganisms were Escherichia coli (36.8%), Staphylococcus aureus (17.7%) and Pseudomonas aeruginosa (10.5%). Meticillin resistance among S. aureus isolates was 76%. Meropenem and amikacin were the most effective agents against to Gram-negative bacteria. Conclusion: In order to detect of the variation and trends of NIs, the data of surveillance activities must be evaluated decisively and regularly with collaboration among infection control team, Infectious Disease clinic, and GSU. © 2010 Düzce Medical Journal.
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    Trocar-Site Hernias After Laparoscopic Cholecystectomy
    (Düzce Üniversitesi, 2011) Önder, Akın; Gümüş, Metehan; Böyük, Abdullah; Girgin, Sadullah; Kapan, Murat
    Introduction: Trocar-site hernia (TH) development after laparoscopic cholecystectomy (LC)is a rare complication. In this study, we aimed to investigate the TH after LC in the light ofcurrent literature.Methods: Between January 2007 and June 2010, the records of the patients with TH in 515patients performed LC analyzed retrospectively in terms of age, sex, location, size, performedprevious operation and risk factors.Results: TH was determined in 3 (0.58%) patients among patients underwent LC. The averageage was 49.67±5.77 and all of them were women. The 10-mm trocars entry site related to THappeared at umbilical region for 2 patients and at epigastric region for patient. The average timefrom LC to TH formation was 18.33±10.97 months. The diameter of the hernia defects were1.33±0.29 cm. The average of body mass index was 30.3 ± 3.1. During the LC, 2 cm in diametergallstone in 1 patient and multiple gallstones smaller than 1 cm in the others were detected.Wound infection at the umbilical trocar region in one patient was detected after LC.Conclusion: Although the risk of TH after LC is rare, 10 mm or larger diameter trocar sitesshould be sutured especially in the patients including risk factors