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    EXPRESSION OF E-CADHERIN, COX-2, P53 AND BCL-2 IN PROSTATE CARCINOMAS: CORRELATION WITH TUMOR DIFFERENTIATION AND METASTATIC POTENTIAL
    (Taylor & Francis Ltd, 2010) Özekinci, Selver; Uzunlar, Ali Kemal; Şentürk, Senem; Gedik, Abdullah; Büyükbayram, H.; Mızrak, Bülent
    Prognostic factors of prostate cancer such as PSA stage Gleason grade and surgical margins have limitations they are inable to indicate metastatic potential The aim of this study was to investigate expression of e-cadherin cox-2 p53 and bcl-2 in prostate carcinomas and to search association with tumor differentiation and metastatic potential Eighty-seven prostate cancer specimens were retreived from tissue blocks embedded in parafin and expression patterns of e-cadherin cox-2 p53 and bcl-2 were investigated by immunoperoxidase method Gleason scoring system was used for tumor grading and expression patterns of these antibodies were compared among different tumor grades Seven cases (8%) had well-differentiated 39(45%) had moderately differentiated and 41 (47%) had poorly differentiated tumors Metastases were present in 31 patients (35%) There was a statistically significant association between tumor differentiation and expression of e-cadherin or bcl-2 (p < 0 01) however no association was found between tumor differentiation and expression of cox-2 or p53 (p > 0 01) There was no association between expressions of e-cadherin cox-2 p53 or bcl-2 and metastasis E-cadherin expression is less frequent in poorly differentiated tumors whereas bcl-2 expression is more frequent However there is no relation with metastatic potential and expression of these markers Expression of cox-2 and p53 is neither related to the degree of differentiation nor to the metastatic potential