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    COMPARISON OF HCV RNA AND HCV CORE ANTIGEN IN GENOTYPE 1 CHRONIC HEPATITIS C PATIENTS
    (Carbone Editore, 2014) Karabay, Oğuz; Öğütlü, Aziz; Ankaralı, Handan; Özdemir, Fatma; Karabay, Meltem; Gözdaş, Hasan Tahsin
    Background: Anti-HCV test is currently used in the diagnosis of hepatitis C, while hepatitis C virus ribonucleic acid (HCV RNA) is used in the determination of viral load. Recently developed hepatitis C virus core antigen (HCV Ag) test is also used in the diagnosis of hepatitis C. The aim of this study was to compare HCV Ag and quantitative HCV RNA in terms of sensitivity and specificity as well as pharmacoeconomic footprint. Patients and methods: Sixty patients with positive anti-HCV were enrolled to this study. Quantitative HCV RNA was studied by ready commercial kits (Qiagen, lower limit of <12 IU/ml). HCV Ag test was studied with microparticule chemiluminiscent immunoassay method using ready commercial kits (Architect HCV Ag, Abbott). Conclusions: HCV Ag and HCV RNA levels were measured in the sera of chronic hepatitis C patients. Quite high correlation was found between the two tests (r = 0.83). According to our results, HCV Ag test may be an alternative to quantitative reverse transcription polymerase chain reaction (PCR) test. Thus, use of HCV Ag in place of HCV RNA will be more cost-effective for countries with limited sources.
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    Elevated mean platelet volume to platelet ratio predicts advanced fibrosis in chronic hepatitis C
    (NLM (Medline), 2020) Gözdaş, Hasan Tahsin; İnce, Nevin
    OBJECTIVE: Chronic hepatitis C virus (HCV) infection is an important health problem that can cause liver cirrhosis and hepatocellular carcinoma. Recently, novel inflammatory markers from complete blood count have been used as a precursor of many clinical conditions. In this study, we investigated the role of hemogram parameters in predicting advanced liver fibrosis in chronic HCV patients. METHODS: Patients who underwent percutaneous liver biopsy due to chronic HCV infection between 01.01.2011 and 01.08.2019 were included in this study. Liver biopsies were evaluated according to Ishak method. Patients were classified into those with mild fibrosis (F ? 2) and advanced fibrosis (F ? 3). Hemogram parameters of these groups were compared and their efficacy in predicting severe fibrosis was investigated. RESULTS: Of the 81 chronic HCV patients, 38 cases were in the mild fibrosis group and 43 cases were in the severe fibrosis group. Mean platelet volume, mean platelet volume to lymphocyte ratio, mean platelet volume to platelet ratio, and red cell distribution width to platelet ratio of the severe fibrosis group were significantly higher than those of the mild fibrosis group (P < 0.05 for all). In the ROC curve analysis, mean platelet volume to platelet ratio showed the biggest area under the curve in the prediction of advanced fibrosis. CONCLUSION: Mean platelet volume to platelet ratio may be an easy and practical biomarker to gain a preliminary insight into advanced fibrosis in chronic HCV patients.
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    Frequency of nasal helicobacter pylori carriage among cooks
    (Pakistan Medical Assoc, 2013) Karabay, Oğuz; Güçlü, Ertuğrul; Kocoğlu, Esra; Özdemir, Davut; Şencan, İrfan; Karabay, Meltem; Gözdaş, Hasan Tahsin
    Objective: To investigate the frequency of nasal helicobacter pylori carriage among cooks living in Bolu, Ardahan and Sakarya province of Turkey. Methods: A total of 54 cooks (10 from Bolu, 29 from Ardahan and 15 from Sakarya) were enrolled. Nasal helicobacter was tested using polymerase chain reaction. Results: Helicobacter pylori was detected in only one cook. Conclusion: Nasal Helicobacter pylori colonisation ratio in cooks in Turkey was found to be very low. Presumably hand hygiene compliance lowered the frequency.
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    Kastamonu’da 2014-2017 yıllarında Tularemi Şüpheli Olguların Başvuru Esnasındaki Klinik ve Epidemiyolojik Özelliklerinin İncelenmesi
    (Düzce Üniversitesi, 2019) Gözdaş, Hasan Tahsin; Göksel, Abdullah Onur
    Amaç: Tularemi, Francisella tularensis’in neden olduğu bir zoonozdur. Yerel salgınlar ya da sporadik olgular şeklinde görülmektedir. Bu çalışmada, tularemi şüpheli olguların başvuru esnasındaki klinik ve epidemiyolojik özelliklerinin incelenmesi amaçlanmıştır.Gereç ve Yöntemler: 2014-2017 yıllarında tularemi şüpheli 36 olgu başvuru esnasındaki klinik ve epidemiyolojik özellikler açısından retrospektif olarak değerlendirilmiştir. Mikroaglütinasyon testi ile antikor seviyesi 1/160 titre ve üzerinde pozitif saptanan hastalarda tularemi tanısı konulmuştur.Bulgular: Tularemi şüpheli 36 olgudan 4 tanesine (%11) tularemi tanısı konuldu. Tularemi tanısı konulan toplam dört olgunun üçü 2017 yılında (iki olgu Şubat, bir olgu Nisan) diğer biri ise 2016 yılının sonunda (Aralık ayı) başvurmuştu. 2017’de başvuran hastaların ikisi Şubat ayında, bir tanesi ise Nisan ayında başvurmuştu. İki olguda orofarengeal form, bir olguda oküloglandüler form, bir olguda ise glandüler form saptandı. Olguların tamamı aynı bölgeden (Cide ilçesi) gelmişti. Üç olgunun öyküsünde ev çevresinde ölü veya canlı fare, tavşan veya kemirici varlığı mevcuttu.Sonuç: Özellikle kış mevsiminde epidemiyolojik olarak riskli bölgeden gelen servikal lenfadenopatili olgularda ayırıcı tanıda tularemi düşünülmelidir. Endemik bölgelerde, tularemi olgularının yıllık ve mevsimsel dağılım özelliklerinin bilinmesi risk gruplarında erken tanı sağlanmasında faydalı olabilir.