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    Evaluation of Acute and Subacute Toxicity of ISY-CP® Food Herbal Mixture in Rats
    (Düzce Üniversitesi, 2020) Yaşar, Mustafa; Şenoğul, Oğuzhan; Karadeniz, Beste; Gök, Ali; Ağyar Yoldaş, Pınar; Ağan, Kağan
    Objective: Recently, there is a growing interest in medicinal and aromatic plants also the treatment methods by using these plants in traditional and complementary medicine. On the other hand, possible toxicities of medicinal and aromatic plants has lately begun to be researched and it is extremely important to cognize these possibilities for human consumption. Therefore, a research has been conducted to understand the acute/subacute toxicity characteristics of a plant based herbal mixture, ISY-CP® used in remember regeneration therapy method (RTM) in rats. The product contains a mixture of nettle leaves (Urtica dioica), yarrow (Achillea millefolium), thyme (Thymus vulgaris) and horsetail (Equisetum arvense) plants. The aim of this research was to examine the effects of ISY-CP® herbal mixture in term of toxicity. Material-Method: In the experimental design, 32 female rats were divided into 4 groups (control, acute, subacute and post-subacute). In order to observe acute and subacute toxicity, clinical observations were performed and the biochemical, hematological and histopathological parameters of the animals were evaluated at the end of the application. Results: According to the results obtained from the study, there were not found significant differences in biochemical, hematological and histopathological evaluations between the control and the application groups. Only phorphorus data is statistically different between subacute toxicity group and control group.Conclusion: In our study, the acute and subacute toxic effects of ISY-CP® herbal mixture’s doses used in this study were not observed.
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    Investigation of Anti-inflammatory, Antioxidative, and Cardioprotective Effects of Combined Metformin and Exercise in Rats
    (Düzce Üniversitesi, 2024) Beyazçiçek, Özge; Beyazçiçek, Ersin; Gök, Ali; Tekbaş, Murat; Diril, Halit; Demir, Şerif
    Aim: This study aimed to investigate the anti-inflammatory, antioxidative and cardioprotective effects of exercise and metformin treatment applied alone or in combination.Material and Methods: In this study, 42 male Wistar rats were used. The rats were separated into six groups as control (CONT), exercise (EXE), 100 mg/kg metformin (M100), 200 mg/kg metformin (M200), 100 mg/kg metformin+exercise (M100+EXE), and 200 mg/kg metformin+exercise (M200+EXE). Exercise was applied for 10 weeks including exercise training. Metformin was administered 30 minutes before exercise. At the end of the study, levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-?), interleukin-6 (IL-6), interleukin-10 (IL-10), cardiac troponin-I (cTn-I), creatine kinase-muscle/brain (CK-MB), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA) in serum samples from rats were quantified using the ELISA method.Results: The combined application of metformin and exercise significantly decreased cTn-I, CK-MB, MDA, TNF-?, CRP and IL-6 levels (p
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    Investigation of the Acute Subacute Toxicity of KL21® Supplementary Food Product in Rats
    (2022) Gök, Ali; Yasar, Mustafa; Saraç, Güliz; Sipahi, Nisa; Ağan, Aydan Fülden
    Objective: KL21®; It is a food supplement using remember regeneration therapy method (RTM). KL21®. Whereas products that containing combined medicinal plants are expected to be beneficial for health, on the other hand, their toxic properties are able to potentially increase due to the interactions of the active ingredients in the plants. With this study, it was aimed to investigate the toxic effect of KL21®. Material-Method: In the study conducted with control (n: 8), acute (n: 8), subacute (n: 8) and post-subacute (n: 8) groups; the daily dose of the product was tested by gavage in 8-week-old female Wistar rats. Biochemical parameters P, Ca, ALB, TG, TP, TC, Creatinine, Bilirubin, GGT, ALP, AST and ALT were analyzed. In hematological parameters; WBC, RBC, PLT, HCT, HGB were examined. Liver, lung, spleen, kidney and heart tissues were investigated histopathologicaly. Clinical observation was made throughout the entire process. Results: When the acute, subacute and post-subacute groups were compared to control, it was observed that there was no significant difference in biochemical, hematological, histopathological terms. No toxicity-related side effects were found in clinical observations. Conclusion: The potential toxic effect of daily use dose of KL21® containing the combined medicinal plant was investigated in vivo. According to the hemogram, biochemistry and pathology tests, it was determined that it does not show acute and subacute toxicity.
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    Systemic Investigation of Acute Toxicity of Some Food Supplements on The Market in Turkey
    (Düzce Üniversitesi, 2020) Yaşar, Mustafa; Şenoğul, Oğuzhan; Gök, Ali; Ağan, Kağan; Ağan, Aydan Fülden; Beyazçiçek, Ersin; Kantarcıoğlu Coşkun, Sinem
    Objective: Along with changing living and working conditions in recent years, changes have occurred in eating habits. People are turning to supplements for many purposes such as supplementing normal nutrition, feeling more energetic, enhancing the immune system by taking vitamins and minerals that they think they do not get enough, and meeting their body's needs when they cannot eat a balanced and healthy diet. Supplements are prepared in various forms using nutrients such as vitamins, minerals, proteins, amino acids, plants, enzymes, fiber and fatty acids. These supplement foods are not intended to treat or prevent any disease. In general, supplement foods; it is not a substitute for natural nutrition, but it is intended to complement its deficiencies. They cannot be recommended and sold instead of medicines. Because of many of these products have natural content, they can be placed on the market without toxicity tests. In the current study, it is planned to observe the effects of acute systemic toxicity of supplements that are used in remember regeneration therapy method (RTM) and sold in the markets with the brands’ name of IST-ARD®, ARD-REM®, DVD-ARD®, KT-REM®, ARDZ-REM®, IST-GLIO®, IST-REM®, ROMX®, and REGULIN®. Material-Method: In the experimental design, there were 10 groups (1 control and 9 application groups) male mice. To observe acute toxicity, clinical observation was performed for 72 hours and the biochemical and histopathological parameters of the animals were evaluated at the end of the application. Results: According to the results obtained from the study, there were not found significant differences in biochemical and histopathological evaluations between the control and the application groups. Conclusion: The acute toxicity effect of the food supplements was not determined. May be further studies with bigger numbers of samples investigating the nephrotoxic effects of these products lighten this matter.