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    Atypically Located Basal Cell Carcinoma: Three Case Reports
    (2020) Karagün, Ebru; Gamsızkan, Mehmet; Eyup, Yavuz; Bahcivan, Atike; Özcan, Yunus; Buyucek, Seyma
    Basal cell carcinoma (BCC) is the most common malignant tumor in humans. It can be seen anywhere in the skin,although more than 80% occurs in areas exposed to the sun, such as the head and neck. Chronic exposure to sunlight is thought to bethe main etiological factor. Although the risk of metastasis in BCC is very low, the tumor may be locally aggressive and cause tissuedestruction. We present three cases of BCC in atypical locations, the waist region, the lateral femoral region, and the perinealregion. No predisposing factor in terms of etiology of BCC was encountered in these patients’ histories. We are presenting ourcases, together with a discussion of the current literature, to emphasize that BCC should be considered even in atypically locatedlesions.
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    Novel mutation identified in the DDB2 gene in patients with xeroderma pigmentosum group-E
    (Wiley, 2020) Karagun, Ebru; Eroz, Recep; Gamsizkan, Mehmet; Baysak, Sevim; Eyup, Yavuz; Ozcan, Yunus
    Background Xeroderma pigmentosum (XP) is a rare photosensitive syndrome, which is divided into eight complementation groups (XP-A to XP-G and XPV) and characterized by skin cancers diagnosed at early age. A family of seven members (age range between 5 and 47 years) with carriers of the novel nonsense mutation that causes XP-E type were included in the current study. Methods DNA was isolated from peripheral blood samples of the proband, and cancer predisposition genes were sequenced with next-generation sequencing. The demographic features and the laboratory, clinical, and histopathological findings of patients were evaluated. Results In the proband, squamous cell carcinoma was first diagnosed in the right-eye cornea at the age of 13 years and then in the left-eye cornea at the age of 15 years. Later, the patient was diagnosed with basosquamous cell carcinoma on the dorsum of the nose at the age of 18 years. After genetic analysis, a novel nonsense c.1063C>T(p.Arg355Ter) pathogenic variation that causes XP-E type was detected as homozygous in the DDB2 gene of the proband and her siblings, 11 and 5 years of age, and as heterozygous in her parents and a 22-year-old brother. Conclusion Because of the occurrence of early termination codon, truncated nonfunctional proteins or proteins with deleterious loss or gain-of-function activities are synthesized in nonsense mutation. Thus, to avoid the development of pathological lesions, it is important that such patients with nonsense mutation stay away from agents that might cause DNA damage and develop an appropriate lifestyle according to this condition.
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    The Psychosocial Impact of Chronic Facial Dermatoses in Adults
    (Mattioli 1885, 2023) Özcan, Yunus; Sungur, Mehmet Ali; Ozcan, Begum Yaman; Eyup, Yavuz; Ozlu, Emin
    Introduction: Skin diseases have negative psychological and social consequences, especially when they are chronic and affect a visible area of the body, such as the face. Objectives: The purpose of this study is to investigate and compare the psychosocial impact of three common chronic dermatoses of the face: acne, rosacea, and seborrheic dermatitis. Methods: The Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS), and Social Appearance Anxiety Scale (SAAS) were used to compare acne, rosacea, and seborrheic dermatitis patients and healthy controls. The relationships between DLQI, HADS, and SAAS results were investigated, as well as their associations with disease duration and severity. Results: The study included 166 acne patients, 134 rosacea patients, 120 seborrheic dermatitis patients, and 124 controls. The patient groups had significantly higher DLQI, HADS, and SAAS scores than the control group. Rosacea patients had the highest DLQI and SAAS scores, as well as the highest anxiety prevalence. Patients with seborrheic dermatitis had the highest rate of depression. The DLQI, HADS, and SAAS results were moderately correlated with each other, but their relationship with disease duration and severity was insignificant or weak at best. Conclusions: Chronic facial dermatoses have a detrimental impact on mood and quality of life. Although patients with acne, rosacea, and seborrheic dermatitis have distinct lesions, the outcomes in terms of quality of life, anxiety, and depression are largely similar. Furthermore, these patients report similar levels of social anxiety as a result of their overall appearance.