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Öğe The Effect of Long Termand Acute Administration of Genistein on Ischemia-reperfusion-induced Arrhythmia(Wiley-Blackwell, 2016) Ekşioğlu, Didem; Erim, Firdevs; Bozdoğan, Ömer; Özarslan, Oğulcan Talat; Orallar, Hayriye Soytürk; Kaya, Salih Tunç; Yaşar, Selçuk…Öğe The Effect of Resveratrol and Glibenclamide on Ischemia/Reperfusion Induced Arrhythmias in STZ-induced Diabetic Rats(Wiley-Blackwell, 2016) Kaya, Salih Tunç; Özaslan, Oğulcan Talat; Ekşioğlu, Didem; Erim, Firdevs; Yaşar, Selçuk; Bozdoğan, Ömer…Öğe The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K-ATP channel(Taylor & Francis Ltd, 2019) Kaya, Salih Tunç; Bozdoğan, Ömer; Özarslan, Talat O.; Taşkın, Eylem; Eksioğlu, Didem; Erim, Firdevs; Yaşar, SelçukContext: Cardiovascular dysfunctions such as life-threatening arrhythmias are one of the main reasons of mortality and morbidity in diabetic patients Objective: We aimed to investigate the long-term effects of resveratrol, berberine and glibenclamide combinations on the ischemia/reperfusion (I/R) induced arrhythmias in streptozotocin (STZ)-induced diabetic rats and to investigate the role of myocardial K-ATP channel in the possible anti-arrhythmic actions of the treatments. Methods: Two days after induction of diabetes, diabetic rats were treated with resveratrol [5 mg/kg, intraperitoneally (i.p.)], berberine (10 mg/kg, i.p) and glibenclamide (5 mg/kg, i.p) for 6 weeks. On the 43th day, experimental animals were subjected to 6-min ischemia and 6-min reperfusion in vivo. Results: The protein expression of Kir6.2 subunits was downregulated in the diabetic hearts. However, all drug treatments restored the protein expression of Kir6.2 subunits. Resveratrol alone and its combination with glibenclamide decreased the arrhythmia score, the arrhythmic period and the incidence of other types of arrhythmias during the reperfusion period. Conclusions: The combination of resveratrol with glibenclamide may alleviate reperfusion-induced arrhythmias via an underlying mechanism not be only associated with the restoration of the protein expression of Kir6.2 subunits but also associated with the other subunits or ion channels underlying cardiac action potential.Öğe Short-term diabetes decreases ischemia reperfusion-induced arrhythmia: the effect of alpha-2 blocker yohimbine and glibenclamide(Tubitak Scientific & Technical Research Council Turkey, 2016) Bozdoğan, Ömer; Kaya, Salih Tunç; Yaşar, Selçuk; Baş, Erçin Çağdaş; Özarslan, Oğulcan Talat; Ekşioğlu, Didem; Erim, FirdevsThis study examined the effect of yohimbine alone and in combination with glibenclamide on ischemia and reperfusion-induced arrhythmias in diabetes. Six minutes of ischemia were produced in 1-week diabetic rats by ligation of the left coronary artery, and 6 min of reperfusion were produced by releasing the artery. A dose of 5 mg/kg of yohimbine and glibenclamide was administered for 7 days prior to the coronary ligation. The blood pressure, heart rate, and arrhythmia were determined from the recorded ECG during the 6 min of ischemia and reperfusion and then compared using a one-way ANOVA statistical program and the chi-square test. The score of arrhythmia calculated from the type and duration of arrhythmia decreased in the diabetic rats (3.5 +/- 1.69 in control, 1.7 +/- 0.81 in diabetes group). The arrhythmia score returned to the control value in the rats that were given a combination of yohimbine and glibenclamide (3 +/- 1.73). Yohimbine is used in the treatment of erectile dysfunction; glibenclamide is used as an antidiabetic drug in diabetic patients and may be a risk factor in the increase of ischemia reperfusion-induced arrhythmias.
