Yazar "Eren, Mehmet Ali" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    The Association Between Microalbuminuria and Carbonmonoxide Diffusion Capacity in Patients with Type-II Diabetes Mellitus
    (Düzce Üniversitesi, 2011) Çelik, Yakup; Eren, Mehmet Ali; Dağ, Omer Faruk; Gencer, Mehmet; Çelik, Hakim; Aksoy, Nurten; Büyükhatipoglu, Hakan
    Aim: Microalbuminuria is an important indicator of microvascular changes. Identifying patientsat this stage is critical, since nephropathy might be at least partly reversible with aggressiveblood glucose control. Based on these facts, we aimed to evaluate whether any microvascularchanges occur in the lungs before microalbuminuria becomes apparent.Material and Methods: We research carbonmonoxide diffusion capacity (DLCO) in bothnormoalbuminuric and microalbuminuric type 2 diabetes mellitus patients. Age and gendermatched 40 microalbuminuric and 40 normoalbuminuric type 2 diabetes mellitus patients, and40 healthy controls were recruited to this study.Results: We evaluated DLCO results among these groups. We found no difference betweenthree groups in terms of DLCO (p=0.947).Conclusion: The results of the study indicate that as microvascular complications(microalbuminuria) develop in the kidneys, possibly no microvascular changes occur in thelungs, if any, the changes do not cause any functional changes in type 2 diabetes mellitus patientsat early stages
  • Küçük Resim
    Öğe
    The Evaluation of SCUBE-1 and sCD40L Levels in Diabetic Nephropathy
    (Düzce Üniversitesi, 2019) Karakaş, Hilal; Eren, Mehmet Ali; Koyuncu, İsmail; Kırhan, İdris; Sabuncu, Tevfik
    Aim: There is a close link between diabetic nephropathy and atherosclerotic heart disease. We aimed to evaluate the changes of SCUBE-1 and sCD40L, which play role in the course of atherosclerosis, with the progression of nephropathy in patients with type 2 diabetes.Material and Methods: Thirty healthy subjects (group 1) and 74 patients with type 2 diabetes (divided into 3 groups as normal albuminuria group (group 2, n=33), moderately increased albuminuria group (group 3, n=22) and severely increased albuminuria group (group 4, n=19)) were enrolled in the study. Plasma SCUBE-1 and sCD40L levels were measured using the enzyme-linked immunosorbent assay technique.Results: Mean SCUBE-1 levels were significantly higher in group 4 compared to group 1 and group 2 (p=0.005 and p=0.014, respectively) and in group 3 compared to group 1 and group 2 (p=0.011 and p=0.028, respectively). Mean sCD40L levels were significantly higher in group 4 than in other three groups (all p lt;0.001), and in group 3 than in group 1 and group 2 (p=0.001 and p=0.016, respectively). Furthermore, SCUBE-1 level was positively correlated with total cholesterol level (r=0.212, p=0.031) and triglyceride (r=0.194, p=0.049). Likewise, sCD40L level was positively correlated with only creatinine level (r=0.297, p=0.002).Conclusion: SCUBE-1 and sCD40L levels increased with the progression of nephropathy in type 2 diabetes. This increment suggested that SCUBE-1 and sCD40L may play key role in the course of atherosclerosis due to diabetic nephropathy and, diabetic nephropathy may affect the levels of these parameters.