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    Analysis of The Relationship between Blood Groups and Lung Cancer Risk Depending on Histology
    (2021) Eren, Canan; Ökten, İlker Nihat; Akbıyık, Ayten Güner
    Aim: Blood group antigens are the first genetic markers discovered. ABO blood groups which are expressed on redblood cell membranes are reported to be associated with malignancy risk. The present study aimed to investigatewhether there is an association between blood groups and patients with lung cancer.Material and Methods: In our study, ıt was reviewed 587 patients with lung cancer whose ABO/Rh blood types wereserologically confirmed. Patients were classified according to blood groups (O, A, B, AB), Rh factor (+, ?) andhistological types of lung cancer as Non-small cell lung carcinoma (NSCLC) and Small cell lung carcinoma (SCLC).The adenocarcinoma (AC) and squamous carcinoma (SC) as subtypes of NSCLC were recorded. The relationship ofABO/Rh blood groups with clinical features, such as age, sex and histological subtype were evaluated.Results: There was no significant association between pathological results and blood groups O, A, B and AB. SCLCpatients had significantly higher frequency of blood type B Rh (-) when compared to NSCLC patients.Conclusion: We observed an association between risk of lung cancer and ABO blood groups. Although the Rh factor isnot effective by itself, patients with the B Rh (-) blood group may have a higher risk than SCLC. Examining therelationship of blood group subtypes with lung cancer cells at the molecular level would be useful to clarify therelationship between lung cancer and blood groups.