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Öğe Echocardiographic approach of left ventricular dysfunctions in essential hypertension(Saudi Med J, 2007) Aliağaoğlu, Cihangir; Atasoy, Mustafa; Güleç, Ali İhsan; Özdemir, Şevki; Erdem, Teoman; Karakuzu, Ali; Engin, Ragıp İsmail…Öğe Generalized dyspigmentation on the body(Wiley, 2009) Aliağaoğlu, Cihangir; Atasoy, Mustafa; Yıldırım, Ümran; Erdem, Teoman; Erdem, Cengizhan; Engin, Ragıp İsmail…Öğe Glutathione S-Transferase M1 and T1 Gene Polymorphisms in Patients with Chronic Plaque-Type Psoriasis: A Case-Control Study(Karger, 2016) Solak, Berna; Karkucak, Mutlu; Turan, Hakan; Ocakoğlu, Gökhan; Sağ, Şebnem Özemri; Uslu, Esma; Erdem, TeomanObjective: To determine the role of glutathione S-transferase (GST) isoenzyme polymorphisms as susceptibility factors in patients with psoriasis in a Turkish cohort. Subjects and Methods: In this case-control study, 105 patients with plaque-type psoriasis and 102 healthy controls were recruited from the dermatology outpatient clinics of two university hospitals. Genomic DNA was extracted from whole blood using a DZ DNA isolation kit. Multiplex PCR was used to determine GSTM1 and GSTT1 polymorphisms in the isolated DNAs. Results: Of the 150 patients with psoriasis, 83 (79%) were identified with the GSTT1 genotype and 22 (21%) with the null genotype. Of the 102 patients in the control group, 69 (67.6%) subjects were identified with the GSTT1 genotype and 33 (32.4%) with the null genotype. There was no significant difference between the patient and control groups (p = 0.063). Regarding the GSTM1 polymorphism, 54 (51.4%) patients were identified with this genotype and 51 (48.6%) with the null genotype; in the control group, 50 (49%) were identified with this genotype and 52 (51%) with the null genotype. Again there was no statistically significant difference between the groups (p = 0.957). Conclusion: In this Turkish cohort of patients with psoriasis, neither GSTT1 nor GSTM1 polymorphisms were associated with disease susceptibility. Larger studies with a wider range of GST isoenzyme are needed. (C) 2015 S. Karger AG, BaselÖğe MBL2 Gene Polymorphism and Risk of Vitiligo in Turkish Patients(Kamla-Raj Enterprises, 2015) Karkucak, Mutlu; Solak, Berna; Turan, Hakan; Uslu, Esma; Yakut, Tahsin; Aliağaoğlu, Cihangir; Erdem, TeomanMannose-Binding Lectin (MBL) plays an important role in innate immunity. MBL2 gene polymorphisms affect MBL serum levels. Therefore, this increases the risk of infection and may result in predisposition to autoimmune diseases. The aim of this study was to investigate whether there is an association between the MBL2 gene codon 54 (allele B: rs1800450, c. 161G>A; p. 54Gly>Asp) polymorphism and vitiligo in Turkish patients. One hundred and one patients who were diagnosed with vitiligo and 101 control subjects were included in the study. The DNA was analyzed using the Kbioscience Competitive Allele Specific PCR (KASP) technique. MBL2 gene codon 54 polymorphism frequencies were compared between the two groups. In statistical analysis, the level of significance was set at p<0.05. No significant differences in frequencies of the A allele were observed between the patient and control groups. It was observed at similar frequencies in both groups (p=0.890). The results suggest that the MBL2 gene Codon 54 polymorphism is not associated with an increased risk for the development of vitiligo in Turkish patients.Öğe Omentin serum levels and omentin gene Val109Asp polymorphism in patients with psoriasis(Wiley, 2014) Turan, Hakan; Yaykaşlı, Kürşat Oğuz; Soğuktaş, Hatice; Yaykaşlı, Emine; Aliağaoğlu, Cihangir; Erdem, Teoman; Bahadır, AnzelBackground Psoriasis is a chronic inflammatory disease of uncertain pathogenesis. Omentin is a new adipokine with anti-inflammatory properties; however, the relationship between psoriasis and omentin has not been fully established yet. Objectives This study was designed to evaluate the relationship between psoriasis and omentin serum levels and Val109Asp polymorphism in exon 4 of the omentin gene. Methods Forty-nine patients with plaque-type psoriasis and 39 healthy subjects were included in the study. Omentin concentrations were determined by using enzyme-linked immunosorbent assay. Val109Asp polymorphism in exon 4 of the omentin gene was assessed by the polymerase chain reaction-restriction fragment length polymorphism method. Genotypes were determined according to the bands formed in agarose electrophoresis gels. In the statistical analysis, the level of significance was set at P<0.05. Results The serum omentin levels of the patients with psoriasis (354.2 +/- 152.0) were found to be significantly lower than those in the control group (488.7 +/- 190.3) (P=0.001). A moderate level negative correlation was determined between serum omentin level and body mass index and waist circumference. No significant differences were observed between the patient and control groups in terms of the genotype and allele frequency of Val109Asp polymorphism in exon 4 of the omentin gene (0.05). Conclusions Omentin serum levels were determined to be low in patients with psoriasis. No significant difference was found regarding Val109Asp polymorphism of the omentin gene. To the best of our knowledge, our study is the first clinical study to examine the relationship between psoriasis and omentin in terms of serum and genomic levels.Öğe Squamous Cell Carcinoma Arising From Lupus Vulgaris On The Neck(Düzce Üniversitesi, 2011) Erdem, Teoman; Aliağaoğlu, Cihangir; Yıldırım, MuzafferLupus vulgaris (LV) is the most commonly encountered form of cutaneous tuberculosis, andthe most common site of involvement is the head and neck. We report the case of a 45-year-oldman with a squamous cell carcinoma arising from a plaque of LV with a 20-year history on themalar region and the neck. The patient presented with a 3-month history of a squamous cellcarcinoma enlarging on the left neck. He has been successfully treated with tumor excision andantituberculous therapyÖğe Tuberculosis verrucosa cutis(2009) Aliağaoğlu, Cihangir; Atasoy, Mustafa; Güleç, Ali İhsan; Özdemir, Şevki; Erdem, Teoman; Engin, Ragıp İsmail; Sunam, G.Tuberculosis verrucosa cutis is a paucibacillary form of cutaneous tuberculosis caused by exogenous re-infection in previously sensitized individuals. The arms and feet were involved in three cases. Gluteal area was involved in one case. Ziehl-Neelsen and periodic acid-Schiff stains did not demonstrate any acid-fast bacilli. Cultures were positive for Mycobacterium tuberculosis except one case. Lesions of tuberculosis verrucosa cutis improved after anti-tuberculous therapy. There were no active organ and other skin tuberculosis.Öğe Tuberculosis verrucosa cutis. Experience from eastern Turkey(Saudi Med J, 2007) Aliağaoğlu, Cihangir; Atasoy, Mustafa; Güleç, Ali İhsan; Özdemir, Şevki; Erdem, Teoman; Karakuzu, Ali; Engin, Ragıp İsmail…
