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Öğe Hepatitis B Virus Infectıon Presenting As Chronıc Inflammatory Demyelinating Polyneuropathy(Düzce Üniversitesi, 2010) Acıman, Esra; Korucu, Osman; Emre, Ufuk; Taşçılar, Nida FatmaChronic inflammatory demyelinating polyneuropathy (CIDP), which is characterized by aprogressive or recurrent loss of motor and sensory peripheral nerves, could be due to manyreasons such as diabetes mellitus, cancer, sarcoidosis. Although, CIDP could develop in patientswith Hepatitis B virus infection (HBVi), HBVi wasnot found to present itself as CIDP. Ourcase is a 60 years old-man whom suddenly developed numbness and weakness in hands andfeet. He was tetraparetic with hypoactive deep tendon reflexes, hypoesthesia and parestesia.Electroneuromyography (ENMG) revealed mixed type demyelinating and sensorialsensorimotor polyneuropathy. At the time of the diagnosis, high values of AST and ALT; lateron, positivity of HBsAg and HBV-DNA were detected. Although liver biopsy showed chronichepatitis and liver fibrosis, he didnot have any history of hepatitis. In conclusion, whileinvestigating the etiology of CIDP, HBVi should be considered even if patients didnot mentionor know any history of hepatitisÖğe Is there any relationship between quality of life and polysomnographically detected sleep parameters/disorders in stable myasthenia gravis?(Springer Heidelberg, 2018) Taşçılar, Nida Fatma; Saracli, Özge; Kurçer, Mehmet Ali; Ankaralı, Handan; Emre, UfukIt is known that quality of life in myasthenia gravis is positively correlated with subjective sleep quality, still no data is available regarding the relationship between QOL and polysomnographically detected sleep parameters and disorders. In this study, we tried to highlighten this relationship, by performing polysomnography. Sleep-related complaints were evaluated in face-to-face interviews with 19 clinically stable MG patients and 26 healthy controls. During the interviews questionnaires assessing sleep quality, excessive daytime sleepiness, fatigue, depression, anxiety, and Turkish version of the MG-QOL 15-item scale [(MG-QOL15(T)] were administered and then an overnight polysomnography was performed. Sleep disorders, especially obstructive sleep apnea and fatigue were higher, whereas subjective sleep duration was significantly lower, in patients than controls. Excessive daytime sleepiness and poor sleep quality were not different between patients and controls. Other than percentage of sleep stage III, which was negatively correlated with MG-QOL15(T) scores, neither other sleep parameters nor sleep disorders were correlated with MG-QOL15(T) scores. MG composite, subjective sleep duration, fatigue severity and Hamilton depression rating scale scores were found to be positively correlated with MG-QOL15(T) scores. It was shown that decreasing disease severity and enhancing psychological well-being will improve patients' quality of life. We recommend that our findings should be repeated in a large prospective cohort of MG patients.Öğe Reliability and validity of the Turkish version of myasthenia gravis-quality of life questionnaire-15 item(Tubitak Scientific & Technical Research Council Turkey, 2016) Taşçılar, Nida Fatma; Saraçlı, Özge; Kurçer, Mehmet Ali; Ankaralı, Handan; Emre, UfukBackground/aim: The myasthenia gravis-quality of life questionnaire 15 item (MG-QOL15) is a validated, short, and easy to use disease-specific quality of life (QOL) tool in myasthenia gravis. Other than Turkish, a lot of versions of the MG-QOL15 have been used in different languages in different cultures. Therefore, the aim of this study was to translate and construct a validated and adapted Turkish version of the MG-QOL15 [ MG-QOL15(T)]. Materials and methods: After translation, back-translation, and comparison of the 2 English versions of the MG-QOL15, it was tested by 22 monolingual healthy individuals and then 23 patients with clinically stable MG. Afterwards, 11 voluntary patients out of these 23 patients were interviewed for a second time. During the second interview, the MG-QOL15(T) and the 36-item short-form health survey (Turkish version) were administered simultaneously. Results: The MG-QOL15(T) was found to have high internal consistency (1st and 2nd evaluation Cronbach's alphas were 0.958 and 0.928, respectively), test-retest reliability, and concurrent validity. The MG-QOL15(T) was negatively correlated with physical functioning, general health, vitality, and social functioning domains and with the physical and mental composite scores of the SF-36. Conclusion: The MG-QOL15(T) is accepted to be a valid, reliable, valuable tool for measuring disease-specific QOL in Turkish patients with MG.Öğe SLEEP DISORDERS IN BEHCET'S DISEASE AND THEIR RELATIONSHIP WITH FATIGUE AND QUALITY OF LIFE(Wiley-Blackwell, 2011) Taşçılar, Nida Fatma; Tekin, Nilgün; Ankaralı, Handan; Sezer, Tuna; Atik, Levent; Emre, Ufuk; Çınar, Fikret…Öğe Sleep disorders in Behcet's disease, and their relationship with fatigue and quality of life(Wiley-Blackwell, 2012) Taşçılar, Nida Fatma; Tekin, Nilgün; Ankaralı, Handan; Sezer, Tuna; Atik, Levent; Emre, Ufuk; Çınar, FikretBehcets disease, a systemic vasculitis, can cause varying degrees of activity limitation, fatigue and quality of life impairment. To date, there have been no studies regarding sleep disturbance and its relationship with fatigue and life quality in Behcets disease. We aimed to evaluate sleep disorders and polysomnographic parameters, and to determine their relationship with fatigue and quality of life in Behcets disease. Fifty-one patients with Behcets disease without any neurological involvement were interviewed regarding sleep disorders. Twenty-one subjects with no sleep complaints were included as the control group. Sleep-related complaints were evaluated in a face-to-face interview. Sleep quality, excessive daytime sleepiness, fatigue, depression, anxiety, disease activity/severity, and quality of life questionnaires and an overnight polysomnography were performed. Prevalences of restless legs syndrome (35.3%) and obstructive sleep apnea syndrome with/without other sleep disorders (32.5%) were higher than in the control group and the general population. Fatigue was higher in patients with restless legs syndrome and obstructive sleep apnea syndrome, and in those with lower minimum oxygen saturation; hence, only patients with restless legs syndrome had quality of life impairment. Sleep efficiency index and sleep continuity index were lower, and wake after sleep onset, respiratory disturbance index and apneahypopnea index were higher than in controls (P < 0.01). Neither sleep disorders nor polysomnographic parameters were related to disease activity and severity. In conclusion, it is important to question sleep disorder followed by a polysomnography, if necessary, in order to improve quality of life and fatigue in Behcets disease.
