Yazar "Ekşioğlu, Didem" seçeneğine göre listele

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    The Effect of Long Termand Acute Administration of Genistein on Ischemia-reperfusion-induced Arrhythmia
    (Wiley-Blackwell, 2016) Ekşioğlu, Didem; Erim, Firdevs; Bozdoğan, Ömer; Özarslan, Oğulcan Talat; Orallar, Hayriye Soytürk; Kaya, Salih Tunç; Yaşar, Selçuk
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    The Effect of Resveratrol and Glibenclamide on Ischemia/Reperfusion Induced Arrhythmias in STZ-induced Diabetic Rats
    (Wiley-Blackwell, 2016) Kaya, Salih Tunç; Özaslan, Oğulcan Talat; Ekşioğlu, Didem; Erim, Firdevs; Yaşar, Selçuk; Bozdoğan, Ömer
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    Short-term diabetes decreases ischemia reperfusion-induced arrhythmia: the effect of alpha-2 blocker yohimbine and glibenclamide
    (Tubitak Scientific & Technical Research Council Turkey, 2016) Bozdoğan, Ömer; Kaya, Salih Tunç; Yaşar, Selçuk; Baş, Erçin Çağdaş; Özarslan, Oğulcan Talat; Ekşioğlu, Didem; Erim, Firdevs
    This study examined the effect of yohimbine alone and in combination with glibenclamide on ischemia and reperfusion-induced arrhythmias in diabetes. Six minutes of ischemia were produced in 1-week diabetic rats by ligation of the left coronary artery, and 6 min of reperfusion were produced by releasing the artery. A dose of 5 mg/kg of yohimbine and glibenclamide was administered for 7 days prior to the coronary ligation. The blood pressure, heart rate, and arrhythmia were determined from the recorded ECG during the 6 min of ischemia and reperfusion and then compared using a one-way ANOVA statistical program and the chi-square test. The score of arrhythmia calculated from the type and duration of arrhythmia decreased in the diabetic rats (3.5 +/- 1.69 in control, 1.7 +/- 0.81 in diabetes group). The arrhythmia score returned to the control value in the rats that were given a combination of yohimbine and glibenclamide (3 +/- 1.73). Yohimbine is used in the treatment of erectile dysfunction; glibenclamide is used as an antidiabetic drug in diabetic patients and may be a risk factor in the increase of ischemia reperfusion-induced arrhythmias.