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    Evaluation of The Characteristics of Patients With Acute Drug Poisoning and Clinical Outcomes in A University Hospital in Region of Southeastern Anatolia
    (Düzce Üniversitesi, 2013) Yılmaz, Zülfikar; Yıldırım, Yaşar; Ebik, Berat; Yıldırım, Serdar; Oto, Ferhat; Ulucan, Fuad; Karakuş, Abdullah
    Introduction: Cases of intoxication is an important part of the patients admitted to GeneralInternal Medicine Intensive Care Unit. The aim of this study is to present the features ofpatients admitted to our General Internal Medicine Intensive Care Unit with acute drugintoxication and clinical outcomes.Material and method: The data of patients with acute drug intoxication admitted to ourGeneral Internal Medicine Intensive Care Unit between June 2010 and December 2012 wereanalysed retrospectively. The patients’ age, gender, etiology, comorbid conditions, bloodpressure, arterial blood gases, hematological and biochemical parameters, treatments andclinical outcomes were evaluated.Results: 81.4% of patients were female, 18.6% were male. The mean age of the patient was30.23 ± 15.44 years. Multi-drug poisoning (51.2%)was the most common cause among thedrug poisoning. 32.5% of the patients had comorbid conditions. The most common comorbidwas psychosis among the disease. Only one patient hospitalized with organophosphateintoxication was need for mechanical ventilation due to extremely secretion. Hemodialysistherapy was performed 2 times in one patient with valproic acid intoxication.Conclusion: The cases of multi-drug intoxications (51.2%) were found to be more in patientswith acute drug intoxication hospitalized into the General Internal Medicine Intensive Careunit. 16.2% of our patients hospitalized with drug intoxication had psychosis
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    How Important Is Liver Damage During COVID-19?
    (2021) Ekın, Nazim; Kılıç, Jihat; Bacaksız, Ferhat; Ebik, Berat
    Aim: The present study aimed to examine the prevalence of liver dysfunction in patients hospitalized due to coronavirus disease 2019 (COVID-19) and to investigate the role of liver dysfunction in predicting intensive care unit admission and mortality. Material and Methods: A total of 2168 patients who had no previously known chronic liver disease and were found to be COVID-19 positive on polymerase chain reaction test were divided into mild and severe COVID-19 groups. The effect of the development of liver damage on the course and prognosis of COVID-19 was investigated. Results:Elevatedliverenzymesdevelopedin26.3%(n=461)ofthepatientswithmild COVID-19 and in 45.3% (n=189) of the patients with severe COVID-19. The highest ALT and AST elevation was detected in patients using more than one drug with antibiotics (p<0.001). Severe hepatitis developed in 1.4% (n=25) of the patients with mild COVID-19 and 6.5% (n=27) of the patients with severe COVID-19 (p<0.001). There was a weak negative correlation between ALT and albumin (p=0.017, r=-0.497), while a weak positive correlation with bilirubin (p=0.024, r=0.352), a moderate positive correlation with ferritin (p=0.016, r=0.504), and a weak positive correlation with INR (p=0.022, r=0.383) were found in patients with severe COVID-19. Conclusion: The results showed that 30% of COVID-19 patients had impaired liver function of varying severity and that liver damage was more common in patients with severe COVID-19. It was also determined that liver damage occurring during COVID-19 was an indicator of intensive care requirement and the mortality risk.