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Öğe Dermatological Side-Effects Developing in Patients Using Targeted Chemotherapy Drugs: A Review of the Literature(2020) Karagün, Ebru; Eşbah, OnurObjectives: Numerous dermatological side-effects are reported with the use of targeted therapies. These adverseevents derive from common signaling pathways implicated in malignant behavior and normal homeostatic activity ofboth the epidermis and dermis.Methods: Patients under follow-up at the Oncology Clinic 12 using bevacizumab, five cetuximab, four sunitinib, foursorafenib, three panitumumab, one pazopanib, one trastuzumab, and one using vemurafenib, were included in thestudy. Patients’ cutaneous drug side-effects were assessed at dermatological examinations before starting treatmentand at months 1, 3, and 6 during treatment.Results: The most common finding was xerosis, seen in 54% (17/31) of our patients receiving targeted treatment.Papulopustular eruption was observed in 63% (12/19) of patients using epidermal growth factor receptor inhibitors.The most common finding in the nails was brittleness-tenderness. Dry mouth was prominent among the mucositisfindings. The four patients with nosebleeds were using antiangiogenesis agents. Papulopustular eruptions emergedin the first month, xerosis in the second and third, dry mouth in the third, and pyogenic granuloma, nail findings, andnosebleeds in the fourth to sixth months.Conclusion: Dermatological side-effects can impact on the patient’s quality of life and cause significant morbidity.Dermatologists and oncologists should therefore collaborate closely to manage these side-effects.Öğe Investigation of Serum Seladin-1/DHCR24 Levels in Breast Cancer Patients(2020) Önmez, Attila; Eşbah, Onur; Şahin, İ Brahim EthemObjective: Seladin-1, an enzyme that catalyzes the cholesterol formation reactionfrom desmosterol, has been shown to be expressed at different levels in various typesof tumor. The purpose of this study was to investigate the relationship between serumseladin-1 levels and clinical characteristics of patients with non-metastatic breastcancer, and to examine the prognostic value of seladin-1 in breast cancer.Methods: Patients aged 18 and over diagnosed with breast cancer usinghistopathological methods at our medical oncology clinic, whose tumor tissue hadbeen surgically removed and who had not yet received any oncological treatment, andwith no distant organ metastasis or additional malignancy, and healthy womenvolunteers as a control group were included in the study. Demographic and laboratorydata were recorded. Serum seladin-1 levels were compared between the patient andcontrol groups.Results: Seventy-three women, 46 patients and 27 controls, were enrolled. Mean ageswere 56±12 years in the patient group and 62±12 in the control group (p=0.055)Seladin-1 levels were lower in the patient group than in the control group (p=0.038).No statistically significant relationship was observed between tumor size and seladin1 levels (p=0.138). No relationship was also determined between patient grades andstages and seladin-1 (p=0.720; p=0.092, respectively).Conclusions: Seladin-1 levels were lower in the serum of breast cancer patients thanin the control group. However, no statistically significant relationship was foundbetween breast cancer prognostic factors and seladin-1 levels. Further research isneeded to clarify the mechanisms underlying the low seladin-1 levels in breast cancerpatients.Öğe Multicenter Evaluation of Patients with Cutaneous Malignant Melanoma in Turkey: MELAS Study(Asian Pacific Organization Cancer Prevention, 2013) Sönmez, Özlem Uysal; Tanrıverdi, Özgür; Eşbah, Onur; Üyetürk, Ümmügül; Helvacı, Kaan; Bal, Öznur; Öksüzoğlu, BernaBackground: Malignant melanoma is a cancer that demonstrates rapid progression and atypical clinically features with a poor prognosis. Aim: This study was performed to determine the clinical characteristics and treatment outcomes of patients with malignant melanoma in Turkey. Methods: The medical records of 98 patients between 2007-2012 at our centers were retrieved from the patient registry. Overall survival (OS) was calculated using the Kaplan-Meier method. Results: In our study, with the median follow-up of all patients with cutaneous MM of 46.3 months, the median OS rate of all cases was 43.6 months and 5-year OS was 48.6%. However, five-year OS rates of patients with localized disease (stage I-II) and node involvement (stage III) were 60.3% and 39.6%, respectively. The median OS of stage IV patients was 8.7 months and 1-year OS rate was 26.2%. We showed that advanced stage, male gender, and advanced age in all patients with MM were significant prognostic factors of OS. Conclusions: Compared with the results of current studies from Western countries, we found similar findings concerning demographical features, histological variables and survival analyses for our patients with cutaneous MM in Turkey.Öğe Pankreatik Nöroendokrin Karsinomda Paraneoplastik Ciddi Sensorimotor Aksonal Polinöropati: Vaka Sunumu ve Literatür Taraması(2022) Akbaş, Türkay; Kantarcıoğlu Coşkun, Sinem; Torun, Serkan; Öztürk, Ayhan; Eşbah, Onur; Onbas, OmerAmaç: Paraneoplastik nörolojik sendromlar (PNSs), kanser öncesi veya kanser sırasında gelişen, sinir sisteminin herhangi bir kısmını etkileyen çeşitli nörolojik hastalıkları içermektedir. Vaka: Yetmiş sekiz yaşında erkek hastanın üç yıl önce üst ekstremitelerde ağrı ve yanma hissi şikayetleri başlamış ve kısa süre sonra kas güçsüzlüğü eklenmiş. Bir yıl önce de alt ekstremitelerde benzer şikayetler ortaya çıkmış. Yoğun bakım ünitesine pnömoni tansıyla yatırılan hastanın yatış esnasında bilinci açık, fakat kuadriplejik ve modifiye Rankin skoru 5 idi. Abdomen bilgisayarlı tomografi karaciğer ve pankreasta kitle lezyonlarının olduğunu gösterdi. Lezyonyonlardan alınan biyopsiler pankreas orjinli küçük hücreli nöroendokrin karsinom olarak raporlandı. Elektrofizyolojik testler ciddi sensorimotor aksonal polinöropati ile uyumluluk gösteriyordu Diğer polinöropati nedenleri dışlandıktan sonra, hastaya paraneoplastik sensorimotor aksonal polinöropati tanısı konuldu. Hastanın fonksiyonel kapasitesi düşük olduğundan palyatif tedavi planlandı. Sonuç: PNS’li hastalarda uygun tedavinin başlanması için erken kanser tanısının konulması önem arz etmektedir.Öğe Presentation of Diffuse Large B-Cell Lymphoma Relapse as a Penile Mass(Galenos Yayincilik, 2016) Öneç, Birgül; Öneç, Kürşad; Esbah, Ali Ümit; Eşbah, Onur…Öğe Prognostic & predictive factors for planning adjuvant chemotherapy of early-stage breast cancer(Wolters Kluwer Medknow Publications, 2017) Eşbah, Onur; Öksüzoğlu, BernaBreast cancer is a heterogeneous disease and may present with different clinical and biological characteristics. At present, breast cancer is divided into molecular subgroups besides its histopathological classification. Decision for adjuvant chemotherapy is made based on not only histopathological characteristics but also molecular and genomic characteristics using indices, guidelines and calculators in early-stage breast cancer. Making a treatment plan through all these prognostic and predictive methods according to risk categories aims at preventing unnecessary or useless treatments. In this review, an attempt to make a general assessment of prognostic and predictive methods is made which may be used for planning individualized therapy and also the comments of the guidelines used by the oncologists worldwide on these methods.
