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    Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance
    (Elsevier Science Sa, 2016) Orhan, Ersin; Garci, Amine; Riedel, Tina; Soudani, Mylene; Dyson, Paul J.; Therrien, Bruno
    Tetranuclear arene ruthenium complexes of the general formula [{Ru-2(p-cymene)(2)(mu(4)-L)}(2)(mu(4)-tpom)](4+) (tpom = tetrakis(4-pyridyloxymethylene)methane) were obtained from the corresponding dinuclear arene ruthenium complexes [Ru-2(p-cymene)(2)(m(4)-L)Cl-2] (L = diethyl-1,2-diazenedicarboxylato (dadc), oxalato (oxa), bis(2-hydroxyethyl)oxamidato (bho), bis{2-(2-hydroxyethoxy)ethyl}ethanediamidato (bhe), 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dihydroxy-3-phenyl-1,4-benzoquinonato (dhpb), 2,5-dibromo-1,4-benzoquinonato (dBrbq), 2,5-dioxido-3-undecyl-1,4-benzoquinonato (dubq), 2,5-dihydroxy-3,6-diphenyl-1,4-benzoquinonato (dhdb), 2,5-dihydroxy-3,6-(3,5-dimethylphenyl)-1,4-benzoquinonato (dhdm), 5,8-dioxido-1,4-naphtoquinonato (donq)) by reaction with the tetradentate tpom ligand and silver trifluoromethanesulfonate. The antiproliferative activity of the tetranuclear complexes was evaluated on cancerous (A2780 and A2780cisR) and non-cancerous (HEK293) cell lines, showing in most cases cancer cell selectivity and, in some cases, low micromolar cytotoxicities (similar to 1 mu M) against a cancer cell line that has acquired resistance to cisplatin. (C) 2015 Elsevier B.V. All rights reserved.
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    Cytotoxicity of arene ruthenium metalla-rectangles incorporating bis-pyridyl diimide linkers
    (Elsevier Science Sa, 2016) Orhan, Ersin; Garci, Amine; Riedel, Tina; Dyson, Paul J.; Therrien, Bruno
    A series of tetranuclear arene ruthenium complexes of the general formula [Ru-4(p-cymene)(4)(mu(2)-L)(2)(mu(4)-OO boolean AND OO)(2)][CF3SO3](4) (L-1 = N,N'-bis(4-pyridylmethyl)-pyromellitic diimide, L-2 = N,N'-bis(4-pyridylmethyl)-naphthalene diimide) were obtained from the corresponding dinuclear arene ruthenium complexes Ru-2(p-cymene)(2)(mu 4-OO boolean AND OO)Cl-2 (OO boolean AND OO = oxalato (oxa), 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dihydroxy-3-phenyl-1,4-benzoquinonato (dhpb), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dioxido-3-undecyl-1,4-benzoquinonato (dubq), 2,5-dihydroxy-3,6-diphenyl-1,4-benzoquinonato (dhdb), 5,8-dioxido-1,4-naphtoquinonato (donq)) by reaction with the bidentate ligands (L-1 and L-2) and silver trifluoromethanesulfonate. The antiproliferative activity of the tetranuclear arene ruthenium metalla-rectangles was evaluated on cancerous (A2780 and A2780cisR) and non-cancerous (HEK293) cell lines, showing in all cases cancer cell selectivity. In general, the metalla-rectangles obtained with L-2 are more potent than those incorporating L-1, and with the exception of [Ru-4(p-cymene)(4)(mu(2)-L-1)(2)(m(4)-dClbq)(2)][CF3SO3](4), they are all more active than cisplatin on the cisplatin resistant A2780cisR cell line. (C) 2016 Elsevier B.V. All rights reserved.