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    Efficacy of preoperative neutrophil-to-lymphocyte ratio in determining lymph node metastases in testicular cancer
    (Cukurova Univ, Fac Medicine, 2021) Koseci, Tolga; Haksoyler, Veysel; Karadeniz, Cemile; Kaya, Dilsa Mizrak; Dilek, Okan; Sungur, Mehmet Ali; Cil, Timucin
    Purpose: Testicular cancer is the most common solid tumor in young men between the ages of 20-35 and has excellent clinical outcomes with appropriate treatment. Neutrophil-to-lymphocyte-ratio (NLR) is related with prognosis and relapse in different solid tumors. We aimed to investigate the relation of presence and size of regional lymph node metastasis with NLR in testicular cancer. Materials and Methods: A total of 72 testicular cancer patients were included in the study. All medical records were retrospectively collected. NLR was calculated as the count of neutrophil divided by the count of lymphocyte. Chest and abdomen computed tomograpy (CT) scans of all patients were evaluated for metastases. Results: The mean age was 32.18 +/- 8.89 years. The pathologic classification was seminoma in 43% and nonseminoma in 57% of patients. Of 72 patients, 32 (44.4%) had lymph node positivity and 40 (55.6%) hadnot. The mean NLR value was 2.63 +/- 1.79 for all cohort. The mean NLR was significantly lower in patients with lymph node negative disease (for lymph node positive and negative disease 3.19 +/- 2.32 and 2.25 +/- 1.06, respectively.). In the ROC analysis, 2.5 was determined as the cut-off value for NLR to assess lymph node status. Conclusion NLR is a cheap and readily available index that can be used to determine lymph node metastases in testicular GCTs.
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    Evaluation of Computed Tomography, Clinical and Laboratory Findings of COVID-19 in Cancer Patients
    (2020) Köşeci, Tolga; Kaya, Ömer; Dilek, Okan; Alişan, İrfan; Çil, Timuçin; Duman, Berna Bozkurt; Haksöyler, Veysel
    Aim: The aim of this study was to evaluate the computed tomography (CT), clinical andlaboratory findings of coronavirus disease 2019 (COVID-19) in cancer patients and to comparethe findings between polymerase chain reaction (PCR) positive and negative patients.Material and Methods: Twenty-three cancer patients with positive PCR tests and 22diagnosed as COVID-19 with clinical and radiological findings were included in the study. CTimages of the patients were evaluated simultaneously by two radiologists. Presence ofcomorbid diseases, symptoms and laboratory values were evaluated.Results: The most common CT involvement pattern was peripheral with 88.9% (n=40).Bilateral lung involvement rate was 57.8% (n=26). The most common finding was groundglass opacities (n=38, 84.5%). 35.6% (n=16) of these were accompanied by consolidation.Multifocal involvement was present in 62.2% (n=28) of the cases. The most frequentlyinvolved lobes were lower lobes. Other relatively common findings were septal thickening,subpleural streaking, and air bronchogram. The median neutrophil, lymphocyte, D-dimer,procalcitonin, C-reactive protein and lactate dehydrogenase values of the patients were 2000mm3, 1200 mm3, 1990 ng/mL, 30.7 mcg/L 15.8 mg/dl, 161 IU/L, respectively.Conclusion: Multifocal and bilateral involvement, and ground glass opacities were the mostcommon findings. However, higher rates of septal thickening, which is generally less common,suggest that the findings may be more severe in cancer patients. Most of the inflammatorymarkers were higher in PCR negative cases. Studies with more patients in multiple centers willprovide better comparison of the findings in cancer patients with the general population.