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Öğe Düzce Üniversitesi Orman Fakültesi öğrencilerinde Sigara, alkol ve madde kullanımı sıklığı ve kullanmaya başlama nedenleri(2010) Mayda, Atilla Senih; Gerçek, Çağdaş Gökçe; Gümüş, Gözde; Demir, Sema; Deniz, Mustafa; Sürücü, Zeynep Pelin; Taner, HevalAmaç: Bu çalışmanın amacı Düzce Üniversitesi Orman Fakültesi Öğrencilerinin sigara, alkol ve diğer bağımlılık oluşturan maddeleri kullanma sıklığını ve kullanmaya başlama nedenlerini belirlemektir. Gereç ve Yöntem: Araştırmanın evreni ve örneklemi Düzce Üniversitesi Orman Fakültesi’nde okuyan 489 öğrencidir. Araştırmanın anket formunda, sosyo-demografik özelliklerle ilgili 24 soru, sigara ile ilgili 8 soru, alkol ile ilgili 6 soru ve madde kullanımı ile ilgili 7 soru bulunmakta idi. Bulgular: Orman Fakültesinde okuyan 489 öğrenciden 398 (%81.4)’ine anket uygulandı. Sigara içme sıklığı %41.6, alkol %40.3 ve madde kullanımı %9.3 olarak bulundu. Sigara ve alkole başlama nedenleri; çevre etkisi, özenti, merak, arkadaş etkisi olarak belirtildi. Sonuç: Üniversite öğrencilerinin sigara, alkol ve madde kullanım sıklıkları araştırmalarla saptanmalı ve öğrencilerin bu maddeleri kullanmaya başlama nedenleri önlenmesi için belirlenmelidir.Öğe Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats(Springer, 2015) Topaloğlu, Naci; Küçük, Adem; Yıldırım, Şule; Tekin, Mustafa; Erdem, Havva; Deniz, MustafaGlucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 mu g GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P < 0.001), whereas GLP-2 pretreatment significantly decreased their levels (P < 0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.Öğe The influence of colon anastomosis levels on liquid phase gastric emptying rate(2004) Günal, Ömer; Deniz, Mustafa; Aslaner, Arif; Sungur, MustafaThe aim of this study was to investigate the effect of colonic anastomoses at different levels on liquid phase gastric emptying rate. Initiation of oral feeding after colorectal surgical procedures depends on the beginning of bowel movements. We hypothesize that surgical procedures which are performed at different colonic levels, may affect gastric motility and may alter the oral feeding starting time. Liquid phase gastric emptying rates of 49 adult male Wistar Albino rats were measured with methyl cellulose phenol red test. Two groups of 14 rats underwent ascending colon or colorectal anastomosis. We also studied a sham-op group (n=14) with laparotomy only and a control group (n=7) with no surgery. Half of each group underwent gastric emptying test on postoperative first (n=7) or tenth (n=7) days. The gastric emptying rates on the first postoperative day were (34.9±1.5%), (50.9±5.2%), and (58.3±4.5%) in colorectal anastomosis, ascending colon anastomosis, and sham-op groups, respectively. While gastric emptying rates returned to the control group levels (71.5±5.7%) on postoperative tenth day, in ascending colon anastomosis (72.5±2.1%) group and sham-op (69±1.8) group, it was still significantly lower in colorectal anastomosis (49.9±7.8%) group compared to the control group level. This study shows that colorectal anastomosis causes a delay in liquid phase gastric emptying rate compared to ascending colon anastomosis. Our findings also imply that the influence of colonic anastomosis on gastric emptying rate appears to be related to the site of colonic anastomosis.Öğe Protective effect of glucagon-like peptide-2 in experimental corrosive esophagitis(Oxford Univ Press Inc, 2015) Tekin, Mustafa; Topaloğlu, Naci; Küçük, Adem; Deniz, Mustafa; Yıldırım, Şule; Erdem, HavvaCorrosive esophageal injuries are one of the life-threatening morbidities leading to esophageal stricture and perforation affecting all age groups but especially children due to accidental ingestions in this age group. Glucagon-like peptide-2 (GLP-2) is an intestinal polypeptide with potent anti-inflammatory effects. Its effects are studied in various studies but not in corrosive esophagitis. We aimed to investigate whether it has protective effect in experimental corrosive esophagitis, in the absence of existing studies into possible links. Twenty-four Wistar-albino rats, weighing 220-240 g, were randomized into three groups (n=8 in each). First group is control, second one is sham operated, and the third one is treatment group. Median laparotomy was made in all groups. In sham and treatment groups, esophagus was loosened and suspended from 1cm proximal to the esophageal junction. The esophagus segment between suspenders was exposed to 0.1mL 5% NaOH for 10 seconds. In the treatment group, rats were given GLP-2 for 7 days intraperitoneally. After 7 days, all rats were sacrified and esophagi were totally removed. In the histopathologic examination, esophageal tissues were compared in terms of inflammation, muscularis mucosa injury, and collagen deposition of tunica muscularis. Histopathologic changes in the esophageal tissues of groups were compared. Histopathologic injury in the GLP-2 treated group was significantly less than sham group (P<0.05). There was statistically significant healing in the GLP-2 treatment group. It is concluded that GLP-2 has a preventive effect on inflammation and collagen accumulation in an experimental corrosive esophagitis. In the light of the information that initial lesions in the early phase are predictors of complications, GLP-2 is a promising agent that has an anti-inflammatory effect in caustic injuries.Öğe A rare spinal reflex in brain death: Bilateral plantar flexion in nuchal rigidity examination(Asean Neurological Assoc, 2023) Deniz, Mustafa; Yabalak, Ahmet; Dinler, KahramanA 74-year-old female patient, who developed a hypoxic brain injury after cardiopulmonary arrest, was diagnosed with brain death on the 4th day of the clinical onset depending on the absence of brainstem reflexes and the intracranial blood circulation in magnetic resonance angiography, and positive apnea test. Bilateral plantar flexion response to the neck flexion was observed while lifting the head for the examination of oculocephalic reflex during the in-service nurse training. The plantar flexion response was observed every time the neck flexion was performed. This finding was interpreted primarily in favor of spinal reflex and the repeated brain death tests confirmed the diagnosis. Regarding the literature, spinal reflexes may emerge in patients with brain death and plantar flexion is among the most common reflexes. These reflexes are usually observed following painful stimuli, during the apnea test or when the patient is taken off the mechanical ventilation. Although the nuchal rigidity examination is not included in the routine diagnosis procedure of brain death, in this paper we report bilateral plantar flexion as a response to the neck flexion in a patient with brain death in the light of the studies found in the literature. We conclude that the introduction of the above-mentioned examination to the diagnosis of brain death will contribute to the improvement of the diagnosis procedure and prevent delays in the preparation of the potential donors.
