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Öğe E-sigaralar: Yeni Bir Fenomen(Düzce Üniversitesi, 2020) Beyazçiçek, Özge; Beyazçiçek, Ersin; Özmerdivenli, Recep; Demir, SerifElektronik sigaralar, geliştirildiğinden beri, tüm dünyada her geçen gün artan bir pazara sahiptir. Günümüzde e-sigara, tütün kullanımı insidansını azaltabilecek yeni bir “tütün” endüstrisini temsil etmektedir. Elektronik nikotin verme sistemi olarak da bilinen elektronik sigaralar minimal bir araçla aerosol haline getirilmiş nikotini vermek üzere tasarlanan cihazlardır. Elektronik sigaraların asıl amacı kullanıcıya sigara içiyor hissini tütün kullanmadan vermektir. E-sigara üreticileri elektronik sigaraları, sigarayı azaltmanın ya da tamamıyla bırakmanın bir yolu olarak pazarlamakla birlikte pek çok kullanıcı, özellikle gençler, e-sigarayı tütün sigarasından daha güvenli olduklarını düşündükleri için tercih etmektedirler. Birçok e-sigara markası marketlerde satılmakta ve bunlara her gün yeni bir tanesi eklenmektedir. Ek olarak, e-sigaralar için birçok farklı tatlandırıcı madde içeren ve birbirinden farklı aromalara sahip çeşitli e-likitler vardır. Bu e-likitlerin ana içerikleri; nikotin, propilen glikol ve bitkisel gliserindir. Çeşitli e-likit içerikleri nedeniyle, e-sigaranın inhalasyondan sonra insan sağlığı üzerindeki etkisi hala belirsizdir. Bu derlemede, e-sigaranın tarihi, çalışma mekanizması, gelişimi ve pazarlaması, bölümleri ve özellikleri, içerdiği maddeler, nikotin ve nikotinin farmakokinetiği, ülkelerin getirdiği düzenlemeler hakkında genel bilgiler ele alınmıştır.Öğe The Effect of Acute And Chronic Harmaline Administration On Penicillin Induced Epileptiform Activity In Rats(Wiley, 2023) Ozkan, Kayhan; Demir, Serif[No abstract available]Öğe Evaluation of the Protective Effect of the Cup Therapy on the Epileptic Seizure in Rats(Duzce Univ, Fac Medicine, 2021) Cetinkaya, Ayhan; Karamaden, Esra Fidan; Goksu, Selim; Bozat, Bihter Gokce; Demir, SerifObjective: Cup therapy has an important place in traditional and complementary medicine applications. The purpose of our study, this is the first time to investigate the protective effect of cup therapy in rats on experimentally generated epileptic seizures in new rat modeling created by different anatomic regions. Methods: A total of 42 Wistar albino rats were randomly divided into 6 groups (n:7). The new dry cup was applied to the G1 group, and the new wet cup model was applied to the G2. In the G3 group, an epilepsy model (PTZ, 35 mg / kg) was created and diazepam (2.5 mg / kg) was given to G4. Dry cup and wet cup models were applied to the G5 and G6 groups, respectively. 24 hours after the cupping therapies, the rats were injected with PTZ and the epilepsy behavior scores of the rats in all groups were recorded for 20-30 minutes. Results: In the 'Open Area' and 'Elevated Plus Maze' tests, there was no behavioral difference between the cup therapy group and the control group (p > 0.05). Given all the parameters, the G4 group significantly reduces the seizure compared to other groups (p < 0.05). There is a significant difference in G2, G5 and G6 groups compared to G3 in the phases parameter (p < 0.05). Conclusions: In this study, the new wet cup therapy (G2), which was applied for the first time, had a protective effect on seizures. G2, G5 and G6 groups are observed to suppress seizures compared to G3. Our findings are expected to contribute greatly to animal model analysis in the future.Öğe Investigation of Physiological Role of Mitochondrial KATP Channel’s on Penicillin G Induced Experimental Epilepsy Model in Rats(E-Journal of New World Sciences Academy, 2021) Soytürk, Hayriye; Demir, Serif; Bozdoğan, ÖmerEpilepsy is one of the neurological diseases that is commonly seen in the world. It is characterized by excessive activation of neurons that can not be controlled by the central nervous system. ATP dependent potassium (KATP) channel modulation is related with the epilepsy. This study is intended to research the physiological role of mitochondrial KATP channels in epilepsy in electrophysiological perspective. And bepridil has been used for this purpose. Wistar albino rats have been used. Animals have been divided into three main groups; Control, bepridil applied groups in pre-seizure, and during seizure. As a result, bepridil once applied prior to seizure in 0.1 and 1mg/kg doses increased the latency period of the seizure. Bepridil showed anticonvulsant effect at doses of 0.1 and 1 mg/kg before and during seizure groups. Closure of sarcoplasmic channels and opening of mitochondrial channels may be important to decrease the convultion occurred during epilepy.Öğe Protective Effect of Cup Therapy Model in Rats on Epileptic Seizures by Determination of Different Anatomic Region(Wiley, 2019) Cetinkaya, Ayhan; Fidan, Esra; Goksu, Selim; Bozat, Bihter Gokce; Demir, Serif[Abstract Not Available]
