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    Malnutrition in Patients with Parkinson's Disease: Associated Clinical Factors
    (Galenos Publ House, 2024) Gultekin, Murat; Ozer, Firuzan Firat; Akin, Sibel; Ozturk, Ahmet; Degirmenci, Yildiz
    Objective: Parkinson's disease (PD) is a chronic, progressive disease commonly affecting the elderly. Among patients with PD (pwPD), those above 60 years old are considered to be at high risk of malnutrition. Weight loss is a common complaint in pwPD. Thus, we defined the risk factors for malnutrition in geriatric pwPD. Materials and Methods: We enrolled 66 pwPD above the age of 60 years. Socio-demographic features were recorded and comprehensive geriatric assessments were evaluated. Malnutrition was assessed using a mini-nutritional assessment questionnaire. Anthropometric measurements including body mass index, mid-upper arm circumference, and calf circumference (CC) were recorded. Results: Seven (10.6%) pwPD had malnutrition, 22 (33.3%) pwPD were at risk of malnutrition. Univariate logistic regression analysis results revealed that low CC, presence of dyskinesia, advanced Hoehn & Yahr stage, levodopa doses of >= 400 mg/day, and difficulty in swallowing (p=0.035, p=0.041, p=0.048, p=0.027 and p=0.007, respectively) were strongly related to malnutrition among the pwPD. Difficulty in swallowing was independently related to malnutrition in pwPD [odds ratio: 7.81 (confidence interval: 2.17-28.10), p=0.002]. Conclusion: PD is the second most common neurodegenerative disease in the geriatric population and is likely to cause malnutrition because of several disabling symptoms in the progressive course of the disease, such as dysphagia. To avoid or delay poorer outcomes, clinicians should be careful to identify malnutrition with appropriate screening tools during follow-up of pwPD.
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    Serum seladin-1 levels in diabetes mellitus and Alzheimer's disease patients
    (Springer Heidelberg, 2020) Onmez, Attila; Alpay, Merve; Torun, Serkan; Sahin, I. Ethem; Onec, Kursad; Degirmenci, Yildiz
    Background Diabetes mellitus (DM) has been shown to increase the risk of Alzheimer's disease (AD). Downregulation of selective Alzheimer's disease indicator-1 (seladin-1) occurs in the cerebral regions affected by AD. However, inconsistent results have been reported for the relationship between seladin-1 levels and AD. The effect of DM on serum seladin-1 levels in AD is unknown. The present study is aimed to investigate serum seladin-1 levels in diabetic and non-diabetic patients with AD. Methods Forty-six patients with AD and 25 healthy volunteers over 65 years of age were included in this study. The patients were divided into three groups-those with AD only, those with DM and AD, and control groups. Demographic characteristics and serum seladin-1 levels were compared among the groups. Results There was no statistically significant difference in seladin-1 levels in the AD only group compared to the control group (p = 0.376). However, seladin-1 levels were significantly lower in the DM and AD group compared to the AD only and control groups (p = 0.002, p = 0.001; respectively). Negative correlations were present between seladin-1 and fasting glucose, postprandial glucose, HbA1c, and insulin (p < 0.05; all). Conclusion Decreased serum seladin-1 values in the presence of DM and inverse correlations with diabetic parameters in patients with AD, together with a non-significant difference from the control group, suggests that seladin-1 may be altered only in the presence of DM in patients with AD. Lower serum seladin-1 levels may also play a role in the pathogenesis of AD in patients with DM.